The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice
Abstract
Female gender affords relative protection from cardiovascular disease until the menopause. We report that estrogen acts on estrogen receptor subtype alpha to up-regulate the production of atheroprotective prostacyclin, PGI 2 , by activation of cyclooxygenase 2 (COX-2). This mechanism restrained both oxidant stress and platelet activation that contribute to atherogenesis in female mice. Deletion of the PGI 2 receptor removed the atheroprotective effect of estrogen in ovariectomized female mice. This suggests that chronic treatment of patients with selective inhibitors of COX-2 could undermine protection from cardiovascular disease in premenopausal females.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moncada, S., Gryglewski, R., Bunting, S., & Vane, J. R. (1976) · Nature · doi:10.1038/263663a0 · Cited by 3,595
McAdam, B. F., Catella-Lawson, F., Mardini, I. A., Kapoor, S., Lawson, J. A., & FitzGerald, G. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.272 · Cited by 1,305
Self-citationTopper, J. N., Cai, J., Falb, D., & Gimbrone, M. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10417 · Cited by 843
Role of Prostacyclin in the Cardiovascular Response to Thromboxane A 2
Cheng, Y., Austin, S. C., Rocca, B., Koller, B. H., Coffman, T. M., Grosser, T., Lawson, J. A., & FitzGerald, G. A. (2002) · Science · doi:10.1126/science.1068711 · Cited by 789
Self-citationAltered pain perception and inflammatory response in mice lacking prostacyclin receptor
Murata, T., Ushikubi, F., Matsuoka, T., Hirata, M., Yamasaki, A., Sugimoto, Y., Ichikawa, A., Aze, Y., Tanaka, T., Yoshida, N., et al. (1997) · Nature · doi:10.1038/41780 · Cited by 773
Collins, P., Rosano, G. M. C., Sarrel, P. M., Ulrich, L., Adamopoulos, S., Beale, C. M., McNeill, J. G., & Poole-Wilson, P. A. (1995) · Circulation · doi:10.1161/01.cir.92.1.24 · Cited by 530
Tangirala, R. K., Rubin, E. M., & Palinski, W. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39713-3 · Cited by 514
Praticò, D., Tangirala, R. K., Rader, D. J., Rokach, J., & FitzGerald, G. A. (1998) · Nature Medicine · doi:10.1038/2685 · Cited by 501
Self-citationHarris, H. A., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (2002) · Endocrinology · doi:10.1210/en.2002-220403 · Cited by 357
Sex, plasma lipoproteins, and atherosclerosis: Prevailing assumptions and outstanding questions
Godsland, I. F., Wynn, V., Crook, D., & Miller, N. E. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90552-7 · Cited by 322
Cited by
Mechanistic Pathways of Sex Differences in Cardiovascular Disease
Regitz-Zagrosek, V., & Kararigas, G. (2017) · Physiological Reviews · doi:10.1152/physrev.00021.2015 · Cited by 732
Prostanoids in health and disease
Smyth, E. M., Grosser, T., Wang, M., Yu, Y., & FitzGerald, G. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800094-jlr200 · Cited by 543
Self-citationTranslating molecular discoveries into new therapies for atherosclerosis
Rader, D. J., & Daugherty, A. (2008) · Nature · doi:10.1038/nature06796 · Cited by 515
Self-citationEndothelial–mesenchymal transition in atherosclerosis
Souilhol, C., Harmsen, M. C., Evans, P. C., & Krenning, G. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvx253 · Cited by 401
Transcription factor cross-talk: the estrogen receptor and NF-κB
Kalaitzidis, D., & Gilmore, T. D. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.01.004 · Cited by 388
Metadata
- Authors
- Egan, K. M., Lawson, J. A., Fries, S., Koller, B., Rader, D. J., Smyth, E. M., & FitzGerald, G. A.
- Venue
- Science
- Published
- 2004-12-10
- Volume
- 306
- Issue
- 5703
- Pages
- 1954-1957
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055691692
- Cited by
- 431
- References
- 15
- FWCI
- 24.05
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice. https://app.cochat.ai/papers/10.1126/science.1103333
- The paper
- Egan, K. M., Lawson, J. A., Fries, S., Koller, B., Rader, D. J., Smyth, E. M., & FitzGerald, G. A. (2004). COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice. Science. https://doi.org/10.1126/science.1103333
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
