Translating molecular discoveries into new therapies for atherosclerosis

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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Inflammation, Atherosclerosis, and Coronary Artery Disease

Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773 · see citing works

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

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Atherosclerosis

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Getting to the site of inflammation: the leukocyte adhesion cascade updated

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Lessons From Sudden Coronary Death: A Comprehensive Morphological Classification Scheme for Atherosclerotic Lesions

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Sequence Variations in <i>PCSK9,</i> Low LDL, and Protection against Coronary Heart Disease

Cohen, J. C., Boerwinkle, E., Mosley, T. H., & Hobbs, H. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054013 · Cited by 3,181 · see citing works

Macrophage activation and polarization

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Effects of torcetrapib in patients at high risk for coronary events

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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The Wellcome Trust Case Control Consortium, U.K.

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Platelet Activation and Atherothrombosis

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Genomewide Association Analysis of Coronary Artery Disease

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Effect of Recombinant ApoA-I Milano on Coronary Atherosclerosis in Patients With Acute Coronary Syndromes: A Randomized Controlled Trial

Nissen, S. E., Tsunoda, T., Tuzcu, E. M., Schoenhagen, P., Cooper, C. J., Yasin, M., Eaton, G. M., Lauer, M. A., Sheldon, W. S., Grines, C. L., et al. (2003) · JAMA · doi:10.1001/jama.290.17.2292 · Cited by 1,707 · see citing works

A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction

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A Common Allele on Chromosome 9 Associated with Coronary Heart Disease

McPherson, R., Pertsemlidis, A., Kavaslar, N., Stewart, A., Roberts, R., Cox, D. R., Hinds, D. A., Pennacchio, L. A., Tybjaerg-Hansen, A., Folsom, A. R., et al. (2007) · Science · doi:10.1126/science.1142447 · Cited by 1,587 · see citing works

Antiinflammatory Properties of HDL

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Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Cohen, J., Pertsemlidis, A., Kotowski, I. K., Graham, R., Garcia, C. K., & Hobbs, H. H. (2005) · Nature Genetics · doi:10.1038/ng1509 · Cited by 1,381 · see citing works

Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E–deficient mice

Daugherty, A., Manning, M. W., & Cassis, L. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7818 · Cited by 1,371 · see citing works

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

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Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

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A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

Cybulsky, M. I., Iiyama, K., Li, H., Zhu, S.-N., Chen, M., Iiyama, M., DAVIS, V. M., Gutierrez-Ramos, J.-C., Connelly, P. W., & Milstone, D. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11871 · Cited by 1,218 · see citing works

Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis

Sata, M., Saiura, A., Kunisato, A., Tojo, A., Okada, S., Tokuhisa, T., Hirai, H., Makuuchi, M., Hirata, Y., & Nagai, R. (2002) · Nature Medicine · doi:10.1038/nm0402-403 · Cited by 1,149 · see citing works

ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins

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Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

Großer, T. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27291 · Cited by 1,028 · see citing works

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

Michelsen, K. S., Wong, M. H., Shah, P. K., Zhang, W., Yano, J., Doherty, T. M., Akira, S., Rajavashisth, T. B., & Arditi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403249101 · Cited by 1,019 · see citing works

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

Joseph, S. B., McKilligin, E., Pei, L., Watson, M. A., Collins, A. R., Laffitte, B. A., Chen, M., Noh, G. J., Goodman, J., Hagger, G. N., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112059299 · Cited by 950 · see citing works

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

Vaisar, T., Pennathur, S., Green, P. S., Gharib, S. A., Hoofnagle, A. N., Cheung, M. C., Byun, J., Vuletic, S., Kassim, S., Singh, P., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26206 · Cited by 942 · see citing works

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

Helgadóttir, A., Manolescu, A. R., Þorleifsson, G., Grétarsdóttir, S., Jonsdottir, H., Þorsteinsdóttir, U., Samani, N. J., Gudmundsson, G. H., Grant, S. F. A., Þorgeirsson, G., et al. (2004) · Nature Genetics · doi:10.1038/ng1311 · Cited by 923 · see citing works

Dual Role of Matrix Metalloproteinases (Matrixins) in Intimal Thickening and Atherosclerotic Plaque Rupture

Newby, A. C. (2005) · Physiological Reviews · doi:10.1152/physrev.00048.2003 · Cited by 817 · see citing works

Myeloperoxidase and Cardiovascular Disease

Nicholls, S. J., & Hazen, S. L. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000163262.83456.6d · Cited by 803 · see citing works

Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease

Tsimikas, S., Brilakis, E. S., Miller, E. R., McConnell, J. P., Lennon, R. J., Kornman, K. S., Witztum, J. L., & Berger, P. B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043175 · Cited by 782 · see citing works

Effects of an Inhibitor of Cholesteryl Ester Transfer Protein on HDL Cholesterol

Brousseau, M. E., Schaefer, E. J., Wolfe, M. L., Bloedon, L. T., Digenio, A. G., Clark, R. W., Mancuso, J. P., & Rader, D. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031766 · Cited by 774 · see citing works

Natural History and Histological Classification of Atherosclerotic Lesions

Stary, H. C. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.5.1177 · Cited by 752 · see citing works

Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL

Binder, C. J., Hörkkö, S., Dewan, A. K., Chang, M.-K., Kieu, E., Goodyear, C. S., Shaw, P. X., Palinski, W., Witztum, J. L., & Silverman, G. J. (2003) · Nature Medicine · doi:10.1038/nm876 · Cited by 735 · see citing works

Effects of Reconstituted High-Density Lipoprotein Infusions on Coronary Atherosclerosis A Randomized Controlled Trial

Tardif, J. (2007) · JAMA · doi:10.1001/jama.297.15.jpc70004 · Cited by 724 · see citing works

Protein carbamylation links inflammation, smoking, uremia and atherogenesis

Wang, Z., Nicholls, S. J., Rodríguez, E. R., Kummu, O., Hörkkö, S., Barnard, J., Reynolds, W. F., Topol, E. J., DiDonato, J. A., & Hazen, S. L. (2007) · Nature Medicine · doi:10.1038/nm1637 · Cited by 706 · see citing works

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

Parmar, K. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24787 · Cited by 705 · see citing works

Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL

Navab, M., Ananthramaiah, G. M., Reddy, S. T., Lenten, B. J. V., Ansell, B. J., Fonarow, G. C., Vahabzadeh, K., Hama, S. Y., Hough, G., Kamranpour, N., et al. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400001-jlr200 · Cited by 687 · see citing works

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking <i>Pcsk9</i>

Rashid, S., Curtis, D. E., Garuti, R., Anderson, N. N., Bashmakov, Y., Ho, Y. K., Hammer, R. E., Moon, Y.-A., & Horton, J. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501652102 · Cited by 679 · see citing works

Endothelial and Antithrombotic Actions of HDL

Mineo, C., Deguchi, H., Griffin, J. H., & Shaul, P. W. (2006) · Circulation Research · doi:10.1161/01.res.0000225982.01988.93 · Cited by 650 · see citing works

Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

Clarke, M. C. H., Figg, N. L., Maguire, J. J., Davenport, A. P., Goddard, M. J., Littlewood, T. D., & Bennett, M. R. (2006) · Nature Medicine · doi:10.1038/nm1459 · Cited by 645 · see citing works

Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis

Tabas, I. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184783.04864.9f · Cited by 641 · see citing works

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

Björkbacka, H., Kunjathoor, V. V., Moore, K. J., Koehn, S., Ordija, C. M., Lee, M. A., Means, T., Halmen, K., Luster, A. D., Golenbock, D. T., et al. (2004) · Nature Medicine · doi:10.1038/nm1008 · Cited by 634 · see citing works

NARC-1/PCSK9 and Its Natural Mutants

Benjannet, S., Rhainds, D., Essalmani, R., Mayne, J., Wickham, L., Jin, W., Asselin, M.-C., Hamelin, J., Varret, M., Allard, D., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409699200 · Cited by 628 · see citing works

Autosomal Recessive Hypercholesterolemia Caused by Mutations in a Putative LDL Receptor Adaptor Protein

Garcia, C. K., Wilund, K., Arca, M., Zuliani, G., Fellin, R., Maioli, M., Calandra, S., Bertolini, S., Cossu, F., Grishin, N., et al. (2001) · Science · doi:10.1126/science.1060458 · Cited by 624 · see citing works

Molecular biology of PCSK9: its role in LDL metabolism

HORTON, J., COHEN, J., & HOBBS, H. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.12.008 · Cited by 621 · see citing works

Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis

Dwyer, J. H., Allayee, H., Dwyer, K. M., Fan, J., Wu, H., Mar, R., Lusis, A. J., & Mehrabian, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025079 · Cited by 614 · see citing works

Molecular regulation of HDL metabolism and function: implications for novel therapies

Rader, D. J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci30163 · Cited by 603 · see citing works

Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo

Wang, X., Collins, H. L., Ranalletta, M., Fuki, I. V., Billheimer, J. T., Rothblat, G. H., Tall, A. R., & Rader, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32057 · Cited by 593 · see citing works

LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors

Mani, A., Radhakrishnan, J., Wang, H., Mani, A., Mani, M.-A., Nelson-Williams, C. J., Carew, K. S., Mane, S., Najmabadi, H., Wu, D., et al. (2007) · Science · doi:10.1126/science.1136370 · Cited by 587 · see citing works

Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia

Cuchel, M., Bloedon, L. T., Szapary, P. O., Kolansky, D. M., Wolfe, M. L., Sarkis, A., Millar, J. S., Ikewaki, K., Siegelman, E. S., Gregg, R. E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa061189 · Cited by 580 · see citing works

Modulation of atherosclerosis in mice by Toll-like receptor 2

Mullick, A. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25482 · Cited by 549 · see citing works

Mouse Models for Atherosclerosis and Pharmaceutical Modifiers

Zadelaar, S., Kleemann, R., Verschuren, L., der Weij, J. D. V.-V., van der Hoorn, J., Princen, H. M. G., & Kooistra, T. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.142570 · Cited by 526 · see citing works

Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques

Llodrá, J., Angeli, V., Liu, J. J., Trogan, E., Fisher, E. A. A., & Randolph, G. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403259101 · Cited by 509 · see citing works

Loss of SR-BI Expression Leads to the Early Onset of Occlusive Atherosclerotic Coronary Artery Disease, Spontaneous Myocardial Infarctions, Severe Cardiac Dysfunction, and Premature Death in Apolipoprotein E–Deficient Mice

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In vivo protection against endotoxin by plasma high density lipoprotein.

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Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice

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IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis

Binder, C. J., Hartvigsen, K., Chang, M.-K., Miller, M., Broide, D. H., Palinski, W., Curtiss, L. K., Corr, M., & Witztum, J. L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20479 · Cited by 451 · see citing works

COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice

Egan, K. M., Lawson, J. A., Fries, S., Koller, B., Rader, D. J., Smyth, E. M., & FitzGerald, G. A. (2004) · Science · doi:10.1126/science.1103333 · Cited by 430 · see citing works

Identification of 5-Lipoxygenase as a Major Gene Contributing to Atherosclerosis Susceptibility in Mice

Mehrabian, M., Allayee, H., Wong, J., Shih, W., Wang, X.-P., Shaposhnik, Z., Funk, C. D., & Lusis, A. J. (2002) · Circulation Research · doi:10.1161/01.res.0000028008.99774.7f · Cited by 422 · see citing works

Lysosomal Cysteine Proteases in Atherosclerosis

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A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction

Helgadóttir, A., Manolescu, A., Helgason, A., Thorleifsson, G., Thorsteinsdottir, U., Gudbjartsson, D., Gretarsdottir, S., Magnússon, K., Gudmundsson, G., Hicks, A., et al. (2006) · Nature Genetics · doi:10.1038/ng1692 · Cited by 390 · see citing works

Pharmacological Activation of Liver X Receptors Promotes Reverse Cholesterol Transport In Vivo

Naik, S. U., Wang, X., Silva, D., Jaye, M., Macphee, C. H., Reilly, M. P., Billheimer, J. T., Rothblat, G. H., & Rader, D. J. (2005) · Circulation · doi:10.1161/circulationaha.105.560177 · Cited by 379 · see citing works

Roles of thromboxane A2 and prostacyclin in the development of atherosclerosis in apoE-deficient mice

Kobayashi, T., Tahara, Y., Matsumoto, M., Iguchi, M., Sano, H., Murayama, T., Arai, H., Oida, H., Yurugi-Kobayashi, T., Yamashita, J. K., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421446 · Cited by 374 · see citing works

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

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Angiotensin II–Induced Hypertension Accelerates the Development of Atherosclerosis in ApoE-Deficient Mice

Weiss, D., Kools, J. J., & Taylor, W. R. (2001) · Circulation · doi:10.1161/01.cir.103.3.448 · Cited by 368 · see citing works

Potent Reduction of Apolipoprotein B and Low-Density Lipoprotein Cholesterol by Short-Term Administration of an Antisense Inhibitor of Apolipoprotein B

Kastelein, J. J. P., Wedel, M. K., Baker, B. F., Su, J. Q., Bradley, J. D., Yu, R. Z., Chuang, E., Graham, M. J., & Crooke, R. M. (2006) · Circulation · doi:10.1161/circulationaha.105.606442 · Cited by 356 · see citing works

The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm

Zhao, L., Moos, M. P. W., Gräbner, R., Pédrono, F., Fan, J., Kaiser, B., John, N. F. S., Schmidt, S., Spanbroek, R., Lötzer, K., et al. (2004) · Nature Medicine · doi:10.1038/nm1099 · Cited by 353 · see citing works

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)

Pajukanta, P., Lilja, H. E., Sinsheimer, J. S., Cantor, R. M., Lusis, A. J., Gentile, M., Duan, X. J., Soro‐Paavonen, A., Naukkarinen, J., Saarela, J., et al. (2004) · Nature Genetics · doi:10.1038/ng1320 · Cited by 347 · see citing works

Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice

Trogan, E., Feig, J. E., Doğan, S., Rothblat, G. H., Angeli, V., Tacke, F., Randolph, G. J., & Fisher, E. A. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511043103 · Cited by 346 · see citing works

The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation

Cuff, C. A., Kothapalli, D., Azonobi, I., Chun, S. H., Zhang, Y., Belkin, R., Yeh, C., Secreto, A. J., Assoian, R. K., Rader, D. J., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112455 · Cited by 330 · see citing works

Leukotriene modifiers as potential therapeutics for cardiovascular disease

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Mechanisms of Disease: Toll-like receptors in cardiovascular disease

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Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis?

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Macrophage Liver X Receptor Is Required for Antiatherogenic Activity of LXR Agonists

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Nonvalidation of Reported Genetic Risk Factors for Acute Coronary Syndrome in a Large-Scale Replication Study

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Antagonism of the prostaglandin D 2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans

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Plaque Rupture in Humans and Mice

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Expression of 5-lipoxygenase and leukotriene A 4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability

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