The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Spindle Multipolarity Is Prevented by Centrosomal Clustering
Abstract
Most tumor cells are characterized by increased genomic instability and chromosome segregational defects, often associated with hyperamplification of the centrosome and the formation of multipolar spindles. However, extra centrosomes do not always lead to multipolarity. Here, we describe a process of centrosomal clustering that prevented the formation of multipolar spindles in noncancer cells. Noncancer cells needed to overcome this clustering mechanism to allow multipolar spindles to form at a high frequency. The microtubule motor cytoplasmic dynein was a critical part of this coalescing machinery, and in some tumor cells overexpression of the spindle protein NuMA interfered with dynein localization, promoting multipolarity.
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Cites
Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.
Gaglio, T., Saredi, A., Bingham, J. B., Hasbani, M. J., Gill, S. R., Schroer, T. A., & Compton, D. A. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.2.399 · Cited by 290
Carroll, P. E., Okuda, M., Horn, H. F., Biddinger, P., Stambrook, P. J., Gleich, L. L., Li, Y.-Q., Tarapore, P., & Fukasawa, K. (1999) · Oncogene · doi:10.1038/sj.onc.1202515 · Cited by 279
Cited by
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859
Mitotic catastrophe: a mechanism for avoiding genomic instability
Vitale, I., Galluzzi, L., Castedo, M., & Kroemer, G. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3115 · Cited by 834
Tetraploidy, aneuploidy and cancer
Ganem, N. J., Storchova, Z., & Pellman, D. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.02.011 · Cited by 668
Centrosome Amplification Can Initiate Tumorigenesis in Flies
Basto, R., Brunk, K., Vinadogrova, T., Peel, N., Franz, A., Khodjakov, A., & Raff, J. W. (2008) · Cell · doi:10.1016/j.cell.2008.05.039 · Cited by 560
Mitotic chromosomal instability and cancer: mouse modelling of the human disease
Schvartzman, J.-M., Sotillo, R., & Benezra, R. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2781 · Cited by 414
Metadata
- Authors
- Quintyne, N. J., Reing, J. E., Hoffelder, D. R., Gollin, S. M., & Saunders, W. S.
- Venue
- Science
- Published
- 2005-01-07
- Volume
- 307
- Issue
- 5706
- Pages
- 127-129
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963759286
- Cited by
- 430
- References
- 2
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Quintyne, N. J., Reing, J. E., Hoffelder, D. R., Gollin, S. M., & Saunders, W. S. (2005). Spindle Multipolarity Is Prevented by Centrosomal Clustering. Science. https://doi.org/10.1126/science.1104905
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