Tetraploidy, aneuploidy and cancer
Abstract
Aneuploidy is one of the most obvious differences between normal and cancer cells. However, there remains debate over how aneuploid cells arise and whether or not they are a cause or consequence of tumorigenesis. One proposed route to aneuploid cancer cells is through an unstable tetraploid intermediate. Supporting this idea, recent studies demonstrate that tetraploidy promotes chromosomal aberrations and tumorigenesis in vivo. These tetraploid cells can arise by a variety of mechanisms, including mitotic slippage, cytokinesis failure, and viral-induced cell fusion. Furthermore, new studies suggest that there might not be a ploidy-sensing checkpoint that permanently blocks the proliferation of tetraploid cells. Therefore, abnormal division of tetraploid cells might facilitate genetic changes that lead to aneuploid cancers.
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Polyploidy is considered a prerequisite to aneuploidy.
“Polyploidy is considered a prerequisite to aneuploidy (Fujiwara et al., 2005, Ganem et al., 2007, Storchova and Kuffer, 2008, Thompson et al., 2010, Vitale et al., 2010)”
From Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression (2011) · cites this paper as Ganem et al., 2007
The polyploidy observed in Mdm2 transgenic cells is likely due at least in part to inhibition of p53 by Mdm2.
“Since Mdm2 negatively regulates p53 (Marine and Lozano, 2010), and p53 inhibits the development of tetraploidy (Fujiwara et al., 2005, Ganem et al., 2007, Storchova and Kuffer, 2008, Thompson et al., 2010, Vitale et al., 2010), the polyploidy we observed in Mdm2 transgenic cells is likely due at least in part to inhibition of p53 by Mdm2.”
From Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression (2011) · cites this paper as Ganem et al., 2007
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- Authors
- Ganem, N. J., Storchova, Z., & Pellman, D.
- Affiliations
- Harvard University (US)
- Boston Children's Hospital (US)
- Corresponding author
- Pellman, David
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 17
- Issue
- 2
- Pages
- 157-162
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W2045802318
- Cited by
- 668
- References
- 52
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 18 · 2023: 17 · 2022: 18 · 2021: 22 · 2020: 31 · 2019: 39 · 2018: 46 · 2017: 34 · 2016: 38 · 2015: 50 · 2014: 29 · 2013: 43 · 2012: 57
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca098537-09)
- National Cancer Institute (R01CA98537)
- National Institute of General Medical Sciences (T32GM008704)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- tetraploidy, aneuploidy, cancer, carcinogenesis, chromosomal instability, mitotic slippage, cytokinesis failure, polyploidy
- MeSH terms
- Aneuploidy, DNA Replication, Humans, Models, Genetic, Neoplasms, Polyploidy, Tumor Suppressor Protein p53, Genomic Instability, Cell Proliferation
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