The DOI matches its Crossref record; 16 of the 17 references it cites were found in a registry or an index.
Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont
Abstract
Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron, followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal glycans. We found that these bacteria assembled on food particles and mucus, selectively induced outer-membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of liberated hexose sugars, and revealed a capacity to turn to host mucus glycans when polysaccharides were absent from the diet. This flexible foraging behavior should contribute to ecosystem stability and functional diversity.
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“the abundant intestinal bacterium Bacteroides thetaiotaomicron, undergoes changes in gene expression that allow it to predominantly metabolize host-derived glycans when dietary sources of these molecules are unavailable35.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [35]
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Cites
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Self-citationBiodiversity and ecosystem productivity in a fluctuating environment: The insurance hypothesis
Yachi, S., & Loreau, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1463 · Cited by 3,211
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Self-citationH OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE
Hooper, L. V., Midtvedt, T., & Gordon, J. I. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.011602.092259 · Cited by 1,623
Self-citationA Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis
Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V., & Gordon, J. I. (2003) · Science · doi:10.1126/science.1080029 · Cited by 1,353
Self-citationHuman Fecal Flora: The Normal Flora of 20 Japanese-Hawaiians
Moore, W. E. C., & Holdeman, L. V. (1974) · Applied Microbiology · doi:10.1128/am.27.5.961-979.1974 · Cited by 1,144
Xu, J., & Gordon, J. I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734063100 · Cited by 890
Self-citationA Model of Host-Microbial Interactions in an Open Mammalian Ecosystem
Bry, L., Falk, P. G., Midtvedt, T., & Gordon, J. I. (1996) · Science · doi:10.1126/science.273.5280.1380 · Cited by 607
Self-citationCarbon nutrition of Escherichia coli in the mouse intestine
Chang, D., Smalley, D. J., Tucker, D. L., Leatham, M. P., Norris, W. E., Stevenson, S. J., Anderson, A. B., Grissom, J. E., Laux, D. C., Cohen, P. S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307888101 · Cited by 513
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Research works printed but not linked: 1
- We thank D. O'Donnell M. Karlsson S. Wagoner L. Gaynon J. Dant and the University of California San Diego Glycotechnology Core Facility for invaluable assistance and our colleagues R. Ley F. Backhed and E. Sonnenburg for many helpful comments. Supported by NIH grants DK30292 and DK052574. All GeneChip data sets have been deposited in Gene Expression Omnibus under accession number GSE2231 (www.ncbi.nlm.nih.gov/geo).
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An obesity-associated gut microbiome with increased capacity for energy harvest
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Self-citationObesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Self-citationDiversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533
Self-citationHost-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Self-citationGut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
Metadata
- Authors
- Sonnenburg, J. L., Xu, J., Leip, D. D., Chen, C.-H., Westover, B. P., Weatherford, J., Buhler, J. D., & Gordon, J. I.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Gordon, Jeffrey I.
- Venue
- Science
- Published
- 2005-03-25
- Volume
- 307
- Issue
- 5717
- Pages
- 1955-1959
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044977356
- Semantic Scholar
- 5770f825e573c00badca438062410bc63cf95bdc
- Cited by
- 1,184
- References
- 17
- Citations by year
- 2026: 39 · 2025: 40 · 2024: 74 · 2023: 69 · 2022: 79 · 2021: 85 · 2020: 78 · 2019: 52 · 2018: 65 · 2017: 69 · 2016: 76 · 2015: 58 · 2014: 78 · 2013: 53 · 2012: 43
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK‐052574, DK-30292, P30DK052574)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Bacteroides thetaiotaomicron, host-microbe interactions, polysaccharide utilization, glycoside hydrolases, germ-free mice, diet, gut microbiota
- MeSH terms
- Adaptation, Physiological, Animals, Bacterial Proteins, Bacteroides, Cecum, Diet, Dietary Carbohydrates, Germ-Free Life, Glycoside Hydrolases, Hexoses, Intestines, Male, Mucus, Operon, Polysaccharide-Lyases, Polysaccharides, Symbiosis, Transcription, Genetic, Up-Regulation, Gene Expression Regulation, Bacterial, Cluster Analysis, Ecosystem, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Mice
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