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Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont
Abstract
Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron, followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal glycans. We found that these bacteria assembled on food particles and mucus, selectively induced outer-membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of liberated hexose sugars, and revealed a capacity to turn to host mucus glycans when polysaccharides were absent from the diet. This flexible foraging behavior should contribute to ecosystem stability and functional diversity.
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“the abundant intestinal bacterium Bacteroides thetaiotaomicron, undergoes changes in gene expression that allow it to predominantly metabolize host-derived glycans when dietary sources of these molecules are unavailable35.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [35]
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- We thank D. O'Donnell M. Karlsson S. Wagoner L. Gaynon J. Dant and the University of California San Diego Glycotechnology Core Facility for invaluable assistance and our colleagues R. Ley F. Backhed and E. Sonnenburg for many helpful comments. Supported by NIH grants DK30292 and DK052574. All GeneChip data sets have been deposited in Gene Expression Omnibus under accession number GSE2231 (www.ncbi.nlm.nih.gov/geo).
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Metadata
- Authors
- Sonnenburg, J. L., Xu, J., Leip, D. D., Chen, C.-H., Westover, B. P., Weatherford, J., Buhler, J. D., & Gordon, J. I.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Gordon, Jeffrey I.
- Venue
- Science
- Published
- 2005-03-25
- Volume
- 307
- Issue
- 5717
- Pages
- 1955-1959
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044977356
- Semantic Scholar
- 5770f825e573c00badca438062410bc63cf95bdc
- Cited by
- 1,184
- References
- 17
- Citations by year
- 2026: 39 · 2025: 40 · 2024: 74 · 2023: 69 · 2022: 79 · 2021: 85 · 2020: 78 · 2019: 52 · 2018: 65 · 2017: 69 · 2016: 76 · 2015: 58 · 2014: 78 · 2013: 53 · 2012: 43
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK‐052574, DK-30292, P30DK052574)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Bacteroides thetaiotaomicron, host-microbe interactions, polysaccharide utilization, glycoside hydrolases, germ-free mice, diet, gut microbiota
- MeSH terms
- Adaptation, Physiological, Animals, Bacterial Proteins, Bacteroides, Cecum, Diet, Dietary Carbohydrates, Germ-Free Life, Glycoside Hydrolases, Hexoses, Intestines, Male, Mucus, Operon, Polysaccharide-Lyases, Polysaccharides, Symbiosis, Transcription, Genetic, Up-Regulation, Gene Expression Regulation, Bacterial, Cluster Analysis, Ecosystem, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Mice
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