Experimental pain tolerance is decreased and independent of clinical pain intensity in patients with endometriosis
Open accessAbstract
Objective To investigate alterations in tactile, pain thresholds and pain tolerance thresholds in patients with endometriosis using a multimodality approach.Design Cross-sectional study.Setting Multidisciplinary referral center.Patient(s) Women with proven endometriosis (N = 35) and healthy controls (N = 38).Intervention(s) Pain processing was tested using quantitative sensory testing (QST) to investigate sensation, pain, and pain tolerance thresholds for thermal, electrical, and pressure stimuli.Main outcome measure(s) Differences in QST measures in patients with endometriosis and in healthy controls on the endometriosis site and control sites, and the association between QST outcomes and patient characteristics.Result(s) We observed a significantly decreased pain tolerance in patients with endometriosis, independent of clinical pain intensity or revised American Society for Reproductive Medicine stage, compared with healthy controls.Conclusion(s) Increasing knowledge concerning mechanisms underlying the pain of women with endometriosis creates opportunities to develop new treatment options. More attention should be paid not only to treat endometriosis in a surgical or pharmacologic way, but also to desensitize by pain education or cognitive therapy.
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Pain sensitivity is higher among women with endometriosis than in healthy controls.
“Pain sensitivity is higher among women with endometriosis than in healthy controls.51,52”
From Prenatal Origins of Endometriosis Pathology and Pain: Reviewing the Evidence of a Role for Low Testosterone (2023) · cites this paper as [51]
The Results (p. 2; QST: Pressure Stimulation and Electrical Stimulation, p. 5) report lower experimental pain tolerance in women with endometriosis than in healthy controls. But pain-detection thresholds did not differ, so the broader statement that pain sensitivity was higher is supported only for the tolerance measure. (LLM, conf=0.84)
Experimental — accuracy not yet measuredPain sensitivity is higher among women than men.
“For example, pain sensitivity is higher among women than men.51,52”
From Prenatal Origins of Endometriosis Pathology and Pain: Reviewing the Evidence of a Role for Low Testosterone (2023) · cites this paper as [51]
The Discussion (p. 7) describes a comparison between women with and without endometriosis, not between women and men. Searches for sex differences and male–female pain thresholds found no passage in our copy addressing the claimed comparison. (LLM, conf=0.75)
Experimental — accuracy not yet measured
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The evolutionary biology of endometriosis
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- Authors
- van Aken, M., Oosterman, J., van Rijn, T., Woudsma, K., Ferdek, M., Ruigt, G., Kozicz, T., Braat, D., Peeters, A., & Nap, A.
- Affiliations
- Radboud University Nijmegen (NL)
- Jagiellonian University (PL)
- Radboud University Medical Center (NL)
- Rijnstate Hospital (NL)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 110
- Issue
- 6
- Pages
- 1118-1128
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2898908320
- Cited by
- 26
- References
- 78
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 2 · 2023: 4 · 2021: 4 · 2020: 4 · 2019: 1
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Faculty of Arts and Social Sciences, Carleton University (ECSW2014-2411-275)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- endometriosis, pain tolerance, pain threshold, quantitative sensory testing, tactile perception, thermal pain, electrical pain, pressure pain, pain processing, endometriosis-associated pain, pain education, cognitive therapy
- MeSH terms
- Adolescent, Adult, Cross-Sectional Studies, Endometriosis, Female, Humans, Middle Aged, Pain, Pain Measurement, Pain Threshold, Young Adult
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