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Comparative Genomics of Trypanosomatid Parasitic Protozoa
Abstract
A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi , and Leishmania major , three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that—along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions—have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.
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Cites
The timing of eukaryotic evolution: Does a relaxed molecular clock reconcile proteins and fossils?
Douzery, E. J. P., Snell, E. A., Bapteste, E., Delsuc, F., & Philippe, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403984101 · Cited by 638
Salmon, D., Geuskens, M., Hanocq, F., Hanocq-Quertier, J., Nolan, D., Ruben, L., & Pays, E. (1994) · Cell · doi:10.1016/0092-8674(94)90574-6 · Cited by 176
Cited by
Brun, R., Blum, J., Chappuis, F., & Burri, C. (2010) · The Lancet · doi:10.1016/s0140-6736(09)60829-1 · Cited by 926
“Manifesto” for Advancing the Control and Elimination of Neglected Tropical Diseases
Hotez, P. J., & Pecoul, B. (2010) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0000718 · Cited by 138
Gene expression regulation in trypanosomatids
De Gaudenzi, J. G., Noé, G., Campo, V. A., Frasch, A. C., & Cassola, A. (2011) · Essays in Biochemistry · doi:10.1042/bse0510031 · Cited by 116
Zhang, Y., & Sabatini, R. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105432 · Cited by 4
Metadata
- Authors
- El-Sayed, N. M., Myler, P. J., Blandin, G., Berriman, M., Crabtree, J., Aggarwal, G., Caler, E., Renauld, H., Worthey, E. A., Hertz-Fowler, C., Ghedin, E., Peacock, C., Bartholomeu, D. C., Haas, B. J., Tran, A.-N., Wortman, J. R., Alsmark, U. C. M., Angiuoli, S., Anupama, A., Badger, J., Bringaud, F., Cadag, E., Carlton, J. M., Cerqueira, G. C., Creasy, T., Delcher, A. L., Djikeng, A., Embley, T. M., Hauser, C., Ivens, A. C., Kummerfeld, S. K., Pereira-Leal, J. B., Nilsson, D., Peterson, J., Salzberg, S. L., Shallom, J., Silva, J. C., Sundaram, J., Westenberger, S., White, O., Melville, S. E., Donelson, J. E., Andersson, B., Stuart, K. D., & Hall, N.
- Venue
- Science
- Published
- 2005-07-15
- Volume
- 309
- Issue
- 5733
- Pages
- 404-409
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2112711937
- Cited by
- 819
- References
- 2
- FWCI
- 40.79
- Type
- journal article
- Language
- en
- Open access
- closed
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