The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The ß-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel
Abstract
Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a β-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides.
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Citations
Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
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Liu, H., Fergusson, M. M., Castilho, R. M., Liu, J., Cao, L., Chen, J., Malide, D., Rovira, I. I., Schimel, D., Kuo, C. J., et al. (2007) · Science · doi:10.1126/science.1143578 · Cited by 755
Molecular Mechanisms of Vitamin D Action
Haussler, M. R., Whitfield, G. K., Kaneko, I., Haussler, C. A., Hsieh, D., Hsieh, J.-C., & Jurutka, P. W. (2013) · Calcified Tissue International · doi:10.1007/s00223-012-9619-0 · Cited by 759
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Bergwitz, C., & Jüppner, H. (2010) · Annual Review of Medicine · doi:10.1146/annurev.med.051308.111339 · Cited by 741
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Metadata
- Authors
- Chang, Q., Hoefs, S., van der Kemp, A. W., Topala, C. N., Bindels, R. J., & Hoenderop, J. G.
- Venue
- Science
- Published
- 2005-10-21
- Volume
- 310
- Issue
- 5747
- Pages
- 490-493
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2132537604
- Cited by
- 622
- References
- 2
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chang, Q., Hoefs, S., van der Kemp, A. W., Topala, C. N., Bindels, R. J., & Hoenderop, J. G. (2005). The ß-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel. Science. https://doi.org/10.1126/science.1114245
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