The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Drosophila RNAi Screen Reveals CD36 Family Member Required for Mycobacterial Infection
Abstract
Certain pathogens, such as Mycobacterium tuberculosis , survive within the hostile intracellular environment of a macrophage. To identify host factors required for mycobacterial entry and survival within macrophages, we performed a genomewide RNA interference screen in Drosophila macrophage-like cells, using Mycobacterium fortuitum . We identified factors required for general phagocytosis, as well as those needed specifically for mycobacterial infection. One specific factor, Peste (Pes), is a CD36 family member required for uptake of mycobacteria, but not Escherichia coli or Staphylococcus aureus . Moreover, mammalian class B scavenger receptors (SRs) conferred uptake of bacteria into nonphagocytic cells, with SR-BI and SR-BII uniquely mediating uptake of M. fortuitum , which suggests a conserved role for class B SRs in pattern recognition and innate immunity.
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Cites
CD36 is a sensor of diacylglycerides
Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zähringer, U., et al. (2005) · Nature · doi:10.1038/nature03253 · Cited by 873
Cited by
CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior
Silverstein, R. L., & Febbraio, M. (2009) · Science Signaling · doi:10.1126/scisignal.272re3 · Cited by 1,141
Scavenger receptors in homeostasis and immunity
Canton, J., Neculai, D., & Grinstein, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3515 · Cited by 838
Phagosome maturation: going through the acid test
Kinchen, J. M., & Ravichandran, K. S. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2515 · Cited by 555
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
Podrez, E. A., Byzova, T. V., Febbraio, M., Salomon, R. G., Ma, Y., Valiyaveettil, M., Poliakov, E., Sun, M., Finton, P. J., Curtis, B. R., et al. (2007) · Nature Medicine · doi:10.1038/nm1626 · Cited by 513
The phagosome: compartment with a license to kill
Haas, A. (2007) · Traffic · doi:10.1111/j.1600-0854.2006.00531.x · Cited by 450
High-throughput RNAi screening in cultured cells: a user's guide
Echeverri, C. J., & Perrimon, N. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1836 · Cited by 380
Self-citationScavenger receptors: role in innate immunity and microbial pathogenesis
Areschoug, T., & Gordon, S. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01326.x · Cited by 317
Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking
Mehra, A., Zahra, A., Thompson, V., Sirisaengtaksin, N., Wells, A., Porto, M., Köster, S., Penberthy, K., Kubota, Y., Dricot, A., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003734 · Cited by 192
Self-citationIdentification of phagocytosis regulators using magnetic genome-wide CRISPR screens
Haney, M. S., Bohlen, C. J., Morgens, D. W., Ousey, J. A., Barkal, A. A., Tsui, C. K., Ego, B. K., Levin, R., Kamber, R. A., Collins, H., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0254-1 · Cited by 193
Cai, L., Ji, A., de Beer, F. C., Tannock, L. R., & van der Westhuyzen, D. R. (2008) · Journal of Clinical Investigation · doi:10.1172/jci31539 · Cited by 167
Mittal, E., Skowyra, M. L., Uwase, G., Tinaztepe, E., Mehra, A., Köster, S., Hanson, P. I., & Philips, J. A. (2018) · mBio · doi:10.1128/mbio.01765-18 · Cited by 110
Self-citationGilibert, S., Galle-Treger, L., Moreau, M., Saint-Charles, F., Costa, S., Ballaire, R., Couvert, P., Carrié, A., Lesnik, P., & Huby, T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303164 · Cited by 37
Schumacher, N., Yan, K., Gandraß, M., Müller, M., Krisp, C., Häsler, R., Carambia, A., Nofer, J.-R., Bernardes, J. P., Khouja, M., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2020.09.021 · Cited by 24
Metadata
- Authors
- Philips, J. A., Rubin, E. J., & Perrimon, N.
- Venue
- Science
- Published
- 2005-08-19
- Volume
- 309
- Issue
- 5738
- Pages
- 1251-1253
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049798802
- Cited by
- 369
- References
- 1
- FWCI
- 18.01
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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