The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Regulation of Mammalian Tooth Cusp Patterning by Ectodin
Abstract
Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial signaling centers, the enamel knots, form at future cusp positions and are the first signs of cusp patterns that distinguish species. We report that ectodin , a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a “negative” image of mouse enamel knots. Furthermore, we show that ectodin -deficient mice have enlarged enamel knots, highly altered cusp patterns, and extra teeth. Unlike in normal teeth, excess BMP accelerates patterning in ectodin -deficient teeth. We propose that ectodin is critical for robust spatial delineation of enamel knots and cusps.
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Cites
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113
Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
Colosimo, P. F., Hosemann, K. E., Balabhadra, S., Villarreal, G., Dickson, M., Grimwood, J., Schmutz, J., Myers, R. M., Schluter, D., & Kingsley, D. M. (2005) · Science · doi:10.1126/science.1107239 · Cited by 1,448
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Kangas, A. T., Evans, A. R., Thesleff, I., & Jernvall, J. (2004) · Nature · doi:10.1038/nature02927 · Cited by 337
Self-citationWise, a context-dependent activator and inhibitor of Wnt signalling
Itasaki, N., Jones, C. M., Mercurio, S., Rowe, A., Domingos, P. M., Smith, J. C., & Krumlauf, R. (2003) · Development · doi:10.1242/dev.00674 · Cited by 321
Cited by
Bone morphogenetic proteins: a critical review
Bragdon, B., Moseychuk, O., Saldanha, S., King, D., Julian, J., & Nohe, A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.003 · Cited by 691
Secreted and transmembrane wnt inhibitors and activators
Cruciat, C.-M., & Niehrs, C. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a015081 · Cited by 646
Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling
Järvinen, E., Salazar-Ciudad, I., Birchmeier, W., Taketo, M. M., Jernvall, J., & Thesleff, I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607289103 · Cited by 379
Self-citationHotta, Y., Nakamura, H., Konishi, M., Murata, Y., Takagi, H., Matsumura, S., Inoue, K., Fushiki, T., & Itoh, N. (2009) · Endocrinology · doi:10.1210/en.2009-0119 · Cited by 352
Molecular and cellular mechanisms of tooth development, homeostasis and repair
Yu, T., & Klein, O. D. (2020) · Development · doi:10.1242/dev.184754 · Cited by 267
Metadata
- Authors
- Kassai, Y., Munne, P., Hotta, Y., Penttilä, E., Kavanagh, K., Ohbayashi, N., Takada, S., Thesleff, I., Jernvall, J., & Itoh, N.
- Venue
- Science
- Published
- 2005-09-23
- Volume
- 309
- Issue
- 5743
- Pages
- 2067-2070
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1988765975
- Cited by
- 298
- References
- 4
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kassai, Y., Munne, P., Hotta, Y., Penttilä, E., Kavanagh, K., Ohbayashi, N., Takada, S., Thesleff, I., Jernvall, J., & Itoh, N. (2005). Regulation of Mammalian Tooth Cusp Patterning by Ectodin. Science. https://doi.org/10.1126/science.1116848
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