Wise, a context-dependent activator and inhibitor of Wnt signalling
Open accessAbstract
We have isolated a novel secreted molecule, Wise, by a functional screen for activities that alter the anteroposterior character of neuralised Xenopus animal caps. Wise encodes a secreted protein capable of inducing posterior neural markers at a distance. Phenotypes arising from ectopic expression or depletion of Wise resemble those obtained when Wnt signalling is altered. In animal cap assays, posterior neural markers can be induced by Wnt family members, and induction of these markers by Wise requires components of the canonical Wnt pathway. This indicates that in this context Wise activates the Wnt signalling cascade by mimicking some of the effects of Wnt ligands. Activation of the pathway was further confirmed by nuclear accumulation of β-catenin driven by Wise. By contrast, in an assay for secondary axis induction, extracellularly Wise antagonises the axis-inducing ability of Wnt8. Thus, Wise can activate or inhibit Wnt signalling in a context-dependent manner. The Wise protein physically interacts with the Wnt co-receptor,lipoprotein receptor-related protein 6 (LRP6), and is able to compete with Wnt8 for binding to LRP6. These activities of Wise provide a new mechanism for integrating inputs through the Wnt coreceptor complex to modulate the balance of Wnt signalling.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
A series of normal stages in the development of the chick embryo
Hamburger, V., & Hamilton, H. L. (1951) · Journal of Morphology · doi:10.1002/jmor.1050880104 · Cited by 12,254 · see citing works
LDL-receptor-related proteins in Wnt signal transduction
Tamai, K., Semënov, M. V., Kato, Y., Spokony, R. F., Liu, C., Katsuyama, Y., Hess, F. J., Saint‐Jeannet, J., & He, X. (2000) · Nature · doi:10.1038/35035117 · Cited by 1,334 · see citing works
Smith, W. C., & Harland, R. M. (1992) · Cell · doi:10.1016/0092-8674(92)90316-5 · Cited by 1,184 · see citing works
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
Liem, K. F., Tremml, G., Roelink, H., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90276-7 · Cited by 1,071 · see citing works
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,042 · see citing works
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W. (2000) · Nature · doi:10.1038/35011068 · Cited by 1,013 · see citing works
Self-citationBrunkow, M. E., Gardner, J. C., Van Ness, J., Paeper, B. W., Kovacevich, B. R., Proll, S., Skonier, J. E., Zhao, L., Sabo, P. J., Fu, Y.-H., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/318811 · Cited by 1,011 · see citing works
Dishevelled controls cell polarity during Xenopus gastrulation
Wallingford, J. B., Rowning, B. A., Vogeli, K. M., Rothbächer, U., Fraser, S. E., & Harland, R. M. (2000) · Nature · doi:10.1038/35011077 · Cited by 751 · see citing works
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
Semënov, M. V., Tamai, K., Brott, B. K., Kühl, M., Sokol, S. Y., & He, X. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00290-1 · Cited by 700 · see citing works
Tada, M., & Smith, J. C. (2000) · Development · doi:10.1242/dev.127.10.2227 · Cited by 675 · see citing works
Self-citationAxelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T., & Perrimon, N. (1998) · Genes & Development · doi:10.1101/gad.12.16.2610 · Cited by 659 · see citing works
Smith, W. C., & Harland, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90070-f · Cited by 649 · see citing works
Peer Bork, B. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80155-n · Cited by 623 · see citing works
McMahon, A. P., Joyner, A. L., Bradley, A., & McMahon, J. A. (1992) · Cell · doi:10.1016/0092-8674(92)90222-x · Cited by 584 · see citing works
Ectodermal Wnt Function as a Neural Crest Inducer
García‐Castro, M. I., Marcelle, C., & Bronner-Fraser, M. E. (2002) · Science · doi:10.1126/science.1070824 · Cited by 537 · see citing works
Brannon, M. K., Gomperts, M., Sumoy, L., Moon, R. T., & Kimelman, D. (1997) · Genes & Development · doi:10.1101/gad.11.18.2359 · Cited by 522 · see citing works
Kiecker, C. M., & Niehrs, C. (2001) · Development · doi:10.1242/dev.128.21.4189 · Cited by 515 · see citing works
Münsterberg, A., Kitajewski, J., Bumcrot, D. A., McMahon, A. P., & Lassar, A. B. (1995) · Genes & Development · doi:10.1101/gad.9.23.2911 · Cited by 511 · see citing works
Neural crest induction in Xenopus: evidence for a two-signal model
LaBonne, C., & Bronner-Fraser, M. E. (1998) · Development · doi:10.1242/dev.125.13.2403 · Cited by 502 · see citing works
Injected Wnt RNA induces a complete body axis in Xenopus embryos
Sokol, S. Y., Christian, J. L., Moon, R. T., & Melton, D. A. (1991) · Cell · doi:10.1016/0092-8674(91)90069-b · Cited by 501 · see citing works
Inhibition of activin receptor signaling promotes neuralization in Xenopus
Hemmati‐Brivanlou, A., & Melton, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90319-0 · Cited by 491 · see citing works
Protein incorporation by isolated amphibian oocytes III. Optimum incubation conditions
Wallace, R. A., Jared, D. W., Dumont, J. N., & Sega, M. W. (1973) · Journal of Experimental Zoology · doi:10.1002/jez.1401840305 · Cited by 482 · see citing works
Christian, J. L., & Moon, R. T. (1993) · Genes & Development · doi:10.1101/gad.7.1.13 · Cited by 453 · see citing works
Suzuki, A., Thies, R. S., Yamaji, N., Song, J. J., Wozney, J. M., Murakami, K., & Ueno, N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10255 · Cited by 448 · see citing works
Analysis of Dishevelled signalling pathways during Xenopus development
Sokol, S. Y. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00750-6 · Cited by 406 · see citing works
Lamb, T. M., & Harland, R. M. (1995) · Development · doi:10.1242/dev.121.11.3627 · Cited by 385 · see citing works
Vertebrate Embryonic Cells Will Become Nerve Cells Unless Told Otherwise
Hemmati‐Brivanlou, A., & Melton, D. A. (1997) · Cell · doi:10.1016/s0092-8674(00)81853-x · Cited by 364 · see citing works
Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus
Glinka, A., Wu, W., Onichtchouk, D., Blumenstock, C., & Niehrs, C. (1997) · Nature · doi:10.1038/39092 · Cited by 350 · see citing works
Hsieh, J.-C., Rattner, A., Smallwood, P. M., & Nathans, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3546 · Cited by 349 · see citing works
Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.Preprint
Hoppler, S., Brown, J. D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.21.2805 · Cited by 346 · see citing works
Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural developmentPreprint
Baker, J. C., Beddington, R. S. P., & Harland, R. M. (1999) · Genes & Development · doi:10.1101/gad.13.23.3149 · Cited by 337 · see citing works
Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signaling
Mao, B., & Niehrs, C. (2003) · Gene · doi:10.1016/s0378-1119(02)01106-x · Cited by 325 · see citing works
Dominguez, I. M., Itoh, K., & Sokol, S. Y. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8498 · Cited by 316 · see citing works
Dorsalization of the neural tube by the non-neural ectoderm
Dickinson, M. E., Selleck, M. A. J., McMahon, A. P., & Bronner-Fraser, M. E. (1995) · Development · doi:10.1242/dev.121.7.2099 · Cited by 300 · see citing works
Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a
Saint‐Jeannet, J., He, X., VARMUS, H. E., & Dawid, I. B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13713 · Cited by 293 · see citing works
Caudalization of neural fate by tissue recombination and bFGF
Cox, W. G., & Hemmati‐Brivanlou, A. (1995) · Development · doi:10.1242/dev.121.12.4349 · Cited by 293 · see citing works
Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development
Danielian, P. S., & McMahon, A. P. (1996) · Nature · doi:10.1038/383332a0 · Cited by 290 · see citing works
Pownall, M. E., Tucker, A. S., Slack, J. M. W., & Isaacs, H. V. (1996) · Development · doi:10.1242/dev.122.12.3881 · Cited by 280 · see citing works
Initiation of Rhombomeric Hoxb4 Expression Requires Induction by Somites and a Retinoid Pathway
Gould, A. P., Itasaki, N., & Krumlauf, R. K. (1998) · Neuron · doi:10.1016/s0896-6273(00)80513-9 · Cited by 273 · see citing works
Self-citationAn essential role for retinoid signaling in anteroposterior neural patterning
Blumberg, B., Bolado, J., Moreno, T. A., Kintner, C. R., Evans, R. M., & Papalopulu, N. (1997) · Development · doi:10.1242/dev.124.2.373 · Cited by 239 · see citing works
Regulation of Wnt/LRP Signaling by Distinct Domains of Dickkopf Proteins
Brott, B. K., & Sokol, S. Y. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6100-6110.2002 · Cited by 234 · see citing works
Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm
Trainor, P. A., & Krumlauf, R. K. (2000) · Nature Cell Biology · doi:10.1038/35000051 · Cited by 229 · see citing works
Self-citationWnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus
McGrew, L. L., Hoppler, S., & Moon, R. T. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00160-3 · Cited by 225 · see citing works
McGrew, L. L., Lai, C.-J., & Moon, R. T. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0027 · Cited by 223 · see citing works
Itasaki, N., Sharpe, J. A., Morrison, A., & Krumlauf, R. K. (1996) · Neuron · doi:10.1016/s0896-6273(00)80069-0 · Cited by 189 · see citing works
Self-citationMutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/β-catenin signalling
Wu, W., Glinka, A., Delius, H., & Niehrs, C. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00868-x · Cited by 183 · see citing works
Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm
Tada, M., Casey, E. S., Fairclough, L. C., & Smith, J. C. (1998) · Development · doi:10.1242/dev.125.20.3997 · Cited by 172 · see citing works
Self-citationLi, L., Mao, J., Sun, L., Liu, W., & Wu, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111131200 · Cited by 168 · see citing works
Axis determination by inhibition of Wnt signaling in XenopusPreprint
Itoh, K., & Sokol, S. Y. (1999) · Genes & Development · doi:10.1101/gad.13.17.2328 · Cited by 163 · see citing works
Protein incorporation by isolated amphibian oocytes. V. Specificity for vitellogenin incorporation.
Wallace, R. A., & Jared, D. W. (1976) · The Journal of Cell Biology · doi:10.1083/jcb.69.2.345 · Cited by 159 · see citing works
Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning
Davidson, G. R., Mao, B., Barrantes, I. D. B., & Niehrs, C. (2002) · Development · doi:10.1242/dev.00154 · Cited by 149 · see citing works
Control of Dorsoventral Somite Patterning by Wnt-1 and β-Catenin
Capdevila, J., Tabin, C., & Johnson, R. L. (1998) · Developmental Biology · doi:10.1006/dbio.1997.8806 · Cited by 140 · see citing works
Specification of the Zebrafish Nervous System by Nonaxial Signals
Woo, K., & Fraser, S. E. (1997) · Science · doi:10.1126/science.277.5323.254 · Cited by 139 · see citing works
McGrew, L. L., Takemaru, K., Bates, R. L., & Moon, R. T. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00136-7 · Cited by 126 · see citing works
Doniach, T. (1993) · Journal of Neurobiology · doi:10.1002/neu.480241003 · Cited by 119 · see citing works
XenopusHindbrain Patterning Requires Retinoid Signaling
Kolm, P. J., Apekin, V., & Sive, H. L. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8754 · Cited by 118 · see citing works
Pera, E. M., & Robertis, E. M. D. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00394-4 · Cited by 117 · see citing works
Domingos, P. M. D. N., Itasaki, N., Jones, C. M., Mercurio, S., Sargent, M. G., Smith, J. C., & Krumlauf, R. K. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0431 · Cited by 115 · see citing works
Self-citationVleminckx, K., Kemler, R., & Hecht, A. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00225-1 · Cited by 113 · see citing works
Assignment of Early Caudal Identity to Neural Plate Cells by a Signal from Caudal Paraxial Mesoderm
Muhr, J., Jessell, T. M., & Edlund, H. (1997) · Neuron · doi:10.1016/s0896-6273(00)80366-9 · Cited by 106 · see citing works
Regulation of eye development by frizzled signaling in Xenopus
Rasmussen, J. T., Deardorff, M. A., Tan, C. L., Rao, M. S., Klein, P. S., & Vetter, M. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071586298 · Cited by 100 · see citing works
Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase
Itoh, K., Tang, T. L., Neel, B. G., & Sokol, S. Y. (1995) · Development · doi:10.1242/dev.121.12.3979 · Cited by 99 · see citing works
Grapin‐Botton, A., Bonnin, M.-A., & Douarin, N. M. L. (1997) · Development · doi:10.1242/dev.124.4.849 · Cited by 92 · see citing works
<i>Xenopus Cyr61</i>regulates gastrulation movements and modulates Wnt signalling
Latinkic, B. V., Mercurio, S., Bennett, B., Hirst, E. M. A., Xu, Q., Lau, L. F., Mohun, T. J., & Smith, J. C. (2003) · Development · doi:10.1242/dev.00449 · Cited by 77 · see citing works
Self-citationItoh, K., & Sokol, S. Y. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00627-2 · Cited by 59 · see citing works
Bradley, L., Sun, B. I., Collins‐Racie, L. A., LaVallie, E., McCoy, J. M., & Sive, H. L. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9873 · Cited by 59 · see citing works
Riding the Crest of the Wnt Signaling Wave
Trainor, P. A., & Krumlauf, R. K. (2002) · Science · doi:10.1126/science.1075454 · Cited by 48 · see citing works
Self-citationProtein incorporation by isolated amphibian oocytes
Wallace, R. A., Ho, T., Salter, D., & Jared, D. W. (1973) · Experimental Cell Research · doi:10.1016/0014-4827(73)90343-1 · Cited by 47 · see citing works
Sokol, S. Y. (1993) · Development · doi:10.1242/dev.118.4.1335 · Cited by 45 · see citing works
An Overview of Xenopus Development
Jones, C. M., & Smith, J. C. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-483-8_28 · Cited by 12 · see citing works
Self-citationCaudalization of neural fate by tissue recombination and bFGF
Cox, W., & Hemmati‐Brivanlou, A. (1995) · HighWire Press Open Archive · Cited by 9 · see citing works
An Overview of Xenopus Development
Jones, C., & Smith, J. C. (2003) · Humana Press eBooks · doi:10.1385/1-59259-270-8:331 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583 · see citing works
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568 · see citing works
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325 · see citing works
Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528 · see citing works
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366 · see citing works
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
Takebe, N., Miele, L., Harris, P., Jeong, W., Bando, H., Kahn, M., Yang, S. X., & Ivy, S. P. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.61 · Cited by 1,255 · see citing works
Towards an integrated view of Wnt signaling in development
van Amerongen, R., & Nusse, R. (2009) · Development · doi:10.1242/dev.033910 · Cited by 1,168 · see citing works
Proximal events in Wnt signal transduction
Angers, S., & Moon, R. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2717 · Cited by 1,106 · see citing works
Osteocytes, mechanosensing and Wnt signaling
Bonewald, L. F., & Johnson, M. L. (2008) · Bone · doi:10.1016/j.bone.2007.12.224 · Cited by 1,076 · see citing works
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044 · see citing works
Function and biological roles of the Dickkopf family of Wnt modulators
Niehrs, C. (2006) · Oncogene · doi:10.1038/sj.onc.1210054 · Cited by 995 · see citing works
Wnt signaling in osteoblasts and bone diseases
Westendorf, J. J., Kahler, R. A., & Schroeder, T. M. (2004) · Gene · doi:10.1016/j.gene.2004.06.044 · Cited by 805 · see citing works
SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor
Semënov, M., Tamai, K., & He, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504308200 · Cited by 771 · see citing works
Bone morphogenetic proteins: a critical review
Bragdon, B., Moseychuk, O., Saldanha, S., King, D., Julian, J., & Nohe, A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.003 · Cited by 691 · see citing works
Secreted and transmembrane wnt inhibitors and activators
Cruciat, C.-M., & Niehrs, C. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a015081 · Cited by 646 · see citing works
WNTS in the vertebrate nervous system: from patterning to neuronal connectivity
Ciani, L., & Salinas, P. C. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1665 · Cited by 631 · see citing works
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
Xu, X., Zhang, M., Xu, F., & Jiang, S. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01276-5 · Cited by 588 · see citing works
A Mechanism for Wnt Coreceptor Activation
Tamai, K., Zeng, X., Liu, C., Zhang, X., Harada, Y., Chang, Z., & He, X. (2004) · Molecular Cell · doi:10.1016/s1097-2765(03)00484-2 · Cited by 556 · see citing works
Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone
Robinson, J. A., Chatterjee‐Kishore, M., Yaworsky, P. J., Cullen, D. M., Zhao, W., Li, C., Kharode, Y. P., Sauter, L., Babij, P., Brown, E. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602308200 · Cited by 522 · see citing works
Wnt signaling: complexity at the surface
Cadigan, K. M., & Liu, Y. I. (2006) · Journal of Cell Science · doi:10.1242/jcs.02826 · Cited by 486 · see citing works
R-Spondin2 Is a Secreted Activator of Wnt/β-Catenin Signaling and Is Required for Xenopus Myogenesis
Kazanskaya, O., Glinka, A., del Barco Barrantes, I., Stannek, P., Niehrs, C., & Wu, W. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.019 · Cited by 431 · see citing works
The role of Dickkopf-1 in bone development, homeostasis, and disease
Pinzone, J. J., Hall, B. M., Thudi, N. K., Vonau, M., Qiang, Y., Rosol, T. J., & Shaughnessy, J. D. (2008) · Blood · doi:10.1182/blood-2008-03-145169 · Cited by 408 · see citing works
Update on Wnt signaling in bone cell biology and bone disease
Monroe, D. G., McGee‐Lawrence, M. E., Oursler, M. J., & Westendorf, J. J. (2011) · Gene · doi:10.1016/j.gene.2011.10.044 · Cited by 388 · see citing works
Toomes, C., Bottomley, H. M., Jackson, R. M., Towns, K. V., Scott, S., Mackey, D. A., Craig, J. E., Jiang, L., Yang, Z., Trembath, R. C., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/383202 · Cited by 381 · see citing works
Wnt/β-catenin signaling directs multiple stages of tooth morphogenesis
Liu, F., Chu, E. Y., Watt, B., Zhang, Y., Gallant, N. M., Andl, T., Yang, S. H., Lu, M., Piccolo, S., Schmidt‐Ullrich, R., et al. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.10.016 · Cited by 381 · see citing works
Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling
Järvinen, E., Salazar‐Ciudad, I., Birchmeier, W., Taketo, M. M., Jernvall, J., & Thesleff, I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607289103 · Cited by 379 · see citing works
Structural Biology and Evolution of the TGF-β FamilyPreprint
Hinck, A. P., Mueller, T. D., & Springer, T. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022103 · Cited by 364 · see citing works
SOST/sclerostin, an osteocyte-derived negative regulator of bone formation
van Bezooijen, R. L., ten Dijke, P., Papapoulos, S. E., & Löwik, C. W. G. M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.02.005 · Cited by 368 · see citing works
Wnt signaling in adult intestinal stem cells and cancer
Krausová, M., & Kořínek, V. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.11.032 · Cited by 362 · see citing works
Tooth shape formation and tooth renewal: evolving with the same signals
Jernvall, J., & Thesleff, I. (2012) · Development · doi:10.1242/dev.085084 · Cited by 360 · see citing works
Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Hu, L., Chen, W., Qian, A., & Li, Y.-P. (2024) · Bone Research · doi:10.1038/s41413-024-00342-8 · Cited by 359 · see citing works
Wnt ProteinsPreprint
Willert, K., & Nusse, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007864 · Cited by 353 · see citing works
Ellies, D. L., Viviano, B. L., McCarthy, J. J., Rey, J., Itasaki, N., Saunders, S., & Krumlauf, R. K. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060810 · Cited by 350 · see citing works
Self-citationNusse, R. (2003) · Development · doi:10.1242/dev.00821 · Cited by 337 · see citing works
Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention
Haussler, M. R., Haussler, C. A., Bartik, L., Whitfield, G. K., Hsieh, J., Slater, S. A., & Jurutka, P. W. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00093.x · Cited by 323 · see citing works
Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches
CANALIS, E. M. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.154 · Cited by 305 · see citing works
de Lau, W. B. M., Snel, ., & Clevers, H. C. (2012) · Genome biology · doi:10.1186/gb-2012-13-3-242 · Cited by 298 · see citing works
Regulation of Mammalian Tooth Cusp Patterning by Ectodin
Kassai, Y., Munne, P., Hotta, Y., Penttilä, E., Kavanagh, K. D., Ohbayashi, N., Takada, S., Thesleff, I., Jernvall, J., & Itoh, N. (2005) · Science · doi:10.1126/science.1116848 · Cited by 298 · see citing works
Pez, F., Lopez, A., Kim, M., Wands, J. R., de Fromentel, C. C., & Merle, P. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.07.001 · Cited by 295 · see citing works
Multiplicity of the interactions of Wnt proteins and their receptors
Kikuchi, A., Yamamoto, H., & Kishida, S. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.11.001 · Cited by 285 · see citing works
van Bezooijen, R. L., Svensson, J. P., Eefting, D., Visser, A., van der Horst, G., Karperien, M., Quax, P. H. A., Vrieling, H., Papapoulos, S. E., ten Dijke, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061002 · Cited by 283 · see citing works
Kamiya, N., Ye, L., Kobayashi, T., Mochida, Y., Yamauchi, M., Kronenberg, H. M., Feng, J. Q., & Mishina, Y. M. (2008) · Development · doi:10.1242/dev.025825 · Cited by 275 · see citing works
New Insights into the Mechanism of Wnt Signaling Pathway Activation
Kikuchi, A., Yamamoto, H., Sato, A., & Matsumoto, S. (2011) · International review of cytology · doi:10.1016/b978-0-12-386035-4.00002-1 · Cited by 259 · see citing works
Königshoff, M., & Eickelberg, O. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0485tr · Cited by 254 · see citing works
Wnt/β-catenin Signaling in Oral Tissue Development and Disease
Liu, F., & Millar, S. E. (2010) · Journal of Dental Research · doi:10.1177/0022034510363373 · Cited by 252 · see citing works
Wnt and the Wnt signaling pathway in bone development and disease
Wang, Y. (2014) · Frontiers in bioscience · doi:10.2741/4214 · Cited by 250 · see citing works
The WNT/Beta-catenin pathway in melanoma
Larue, L. (2006) · Frontiers in bioscience · doi:10.2741/1831 · Cited by 249 · see citing works
Extracellular BMP-antagonist regulation in development and disease: tied up in knots
Walsh, D. W., Godson, C., Brazil, D. P., & Martin, F. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.01.008 · Cited by 246 · see citing works
Yang, K., Wang, X., Zhang, H., Wang, Z., Nan, G., Li, Y., Zhang, F., Mohammed, M. K., Haydon, R. C., Luu, H. H., et al. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.144 · Cited by 241 · see citing works
Avsian-Kretchmer, O., & Hsueh, A. J. W. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0227 · Cited by 228 · see citing works
ten Dijke, P., Krause, C., de Gorter, D. J. J., Löwik, C. W. G. M., & van Bezooijen, R. L. (2008) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.g.01183 · Cited by 225 · see citing works
Qin, K. H., Yu, M. S., Fan, J., Wang, H., Zhao, P., Zhao, G., Zeng, W., Chen, C., Wang, Y., Wang, A., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.01.030 · Cited by 226 · see citing works
LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST
Semënov, M. V., & He, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609509200 · Cited by 222 · see citing works
Kemp, C. R., Willems, E., Abdo, S., Lambiv, L., & Leyns, L. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20408 · Cited by 219 · see citing works
Ahn, Y., Sanderson, B. W., Klein, O. D., & Krumlauf, R. K. (2010) · Development · doi:10.1242/dev.054668 · Cited by 215 · see citing works
Self-citationLRP5 and Wnt Signaling: A Union Made for Bone
Johnson, M. L., Harnish, K., Nusse, R., & Hul, W. V. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040816 · Cited by 211 · see citing works
Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6
Ahn, V. E., Chu, M. L.-H., Choi, H., Tran, D. P., Abo, A., & Weis, W. I. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.003 · Cited by 202 · see citing works
Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex
Mercurio, S., Latinkic, B., Itasaki, N., Krumlauf, R. K., & Smith, J. C. (2004) · Development · doi:10.1242/dev.01045 · Cited by 197 · see citing works
Self-citationLrp4 Modulates Extracellular Integration of Cell Signaling Pathways in Development
Ohazama, A., Johnson, E. B., Ota, M. S., Choi, H. J., Porntaveetus, T., Oommen, S., Itoh, N., Eto, K., Gritli-Linde, A., Herz, J., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004092 · Cited by 196 · see citing works
R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
Bell, S. M., Schreiner, C. M., Wert, S. E., Mucenski, M. L., Scott, W. J., & Whitsett, J. A. (2008) · Development · doi:10.1242/dev.013359 · Cited by 191 · see citing works
Wei, Q., Yokota, C., Semënov, M. V., Doble, B. W., Woodgett, J. R., & He, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701927200 · Cited by 182 · see citing works
Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways
Krause, C., Korchynskyi, O., de Rooij, K. E., Weidauer, S. E., de Gorter, D. J. J., van Bezooijen, R. L., Hatsell, S. J., Economides, A. N., Mueller, T. D., Löwik, C. W. G. M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.153890 · Cited by 177 · see citing works
Signaling in Cell Differentiation and MorphogenesisPreprint
Basson, M. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008151 · Cited by 176 · see citing works
LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
Ren, Q., Chen, J., & Liu, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.670960 · Cited by 171 · see citing works
Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6
Bourhis, E., Wang, W., Tam, C., Hwang, J., Zhang, Y., Spittler, D., Huang, O. W., Gong, Y., Estevez, A., Zilberleyb, I., et al. (2011) · Structure · doi:10.1016/j.str.2011.07.005 · Cited by 169 · see citing works
The role of the Wnt signaling pathway in osteoblast commitment and differentiation
Yavropoulou, M. P., & Yovos, J. G. (2007) · HORMONES · doi:10.14310/horm.2002.1111024 · Cited by 167 · see citing works
BMP antagonists: Their roles in development and involvement in pathophysiology
Yanagita, M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.02.007 · Cited by 162 · see citing works
Crosstalk between Wnt and bone morphogenic protein signaling: A turbulent relationship
Itasaki, N., & Hoppler, S. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22009 · Cited by 161 · see citing works
Self-citationLrp6-mediated canonical Wnt signaling is required for lip formation and fusion
Song, L., Li, Y., Wang, K., Wang, Y., Molotkov, A., Gao, L., Zhao, T., Yamagami, T., Wang, Y., Gan, Q., et al. (2009) · Development · doi:10.1242/dev.037440 · Cited by 161 · see citing works
Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair
Macsai, C. E., Foster, B. K., & Xian, C. J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21342 · Cited by 152 · see citing works
Head-tail patterning of the vertebrate embryo: one, two or many unresolved problems?
Stern, C. D., Charité, J., Deschamps, J., Duboule, D., Durston, A. J., Kmita, M., Nicolas, J.-F., Palmeirim, I., Smith, J. C., & Wolpert, L. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.052095cs · Cited by 150 · see citing works
Self-citationHairless triggers reactivation of hair growth by promoting Wnt signaling
Beaudoin, G. M. J., Sisk, J. M., Coulombe, P. A., & Thompson, C. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507609102 · Cited by 149 · see citing works
Wnt/β-catenin signaling in adult mammalian epithelial stem cells
Kretzschmar, K., & Clevers, H. C. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.05.015 · Cited by 144 · see citing works
Haÿ, E., Laplantine, E., Geoffroy, V., Frain, M., Kohler, T., Müller, R., & Marie, P. J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00349-08 · Cited by 146 · see citing works
Yanagita, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25445 · Cited by 144 · see citing works
USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney
Yanagita, M., Oka, M., Watabe, T., Iguchi, H., Niida, A., Takahashi, S., Akiyama, T., Miyazono, K., Yanagisawa, M., & Sakurai, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.075 · Cited by 144 · see citing works
Satoh, W., Gotoh, T., Tsunematsu, Y., Aizawa, S., & Shimono, A. (2006) · Development · doi:10.1242/dev.02274 · Cited by 142 · see citing works
Wnt/β-catenin Signaling in Normal and Cancer Stem Cells
Valkenburg, K. C., Graveel, C. R., Diegel, C. R., Zhong, Z. A., & Williams, B. O. (2011) · Cancers · doi:10.3390/cancers3022050 · Cited by 141 · see citing works
The Wnt signaling pathway and bone metabolism
Johnson, M. L., & Kamel, M. A. (2007) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32816e06f9 · Cited by 138 · see citing works
Novel Regulators of Kidney Development from the Tips of the Ureteric Bud
Schmidt-Ott, K. M., Yang, J., Chen, X., Wang, H., Paragas, N., Mori, K., Li, J., Lu, B. C., Costantini, F. D., Schiffer, M., et al. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004121127 · Cited by 135 · see citing works
Molecular Bases of the Regulation of Bone Remodeling by the Canonical Wnt Signaling Pathway
Glass, D. A., & Karsenty, G. (2006) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)73002-7 · Cited by 133 · see citing works
Närhi, K. M., Järvinen, E., Birchmeier, W., Taketo, M. M., Mikkola, M. L., & Thesleff, I. (2008) · Development · doi:10.1242/dev.016550 · Cited by 132 · see citing works
Wnt/beta-Catenin Signaling in Glioma
Zhang, K., Zhang, J., Han, L., Pu, P., & Kang, C. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9359-y · Cited by 131 · see citing works
Molecular patterning of the mammalian dentition
Lan, Y., Jia, S., & Jiang, R. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.12.003 · Cited by 130 · see citing works
Johnson, M. L., & Rajamannan, N. M. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9003-3 · Cited by 129 · see citing works
Roles for CCN2 in normal physiological processes
Hall‐Glenn, F., & Lyons, K. M. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0782-7 · Cited by 124 · see citing works
Piters, E., Boudin, E., & Hul, W. V. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.006 · Cited by 124 · see citing works
Lintern, K., Guidato, S., Rowe, A., Saldanha, J. W., & Itasaki, N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.025478 · Cited by 122 · see citing works
Self-citationEstrogen receptor α in osteocytes regulates trabecular bone formation in female mice
Kondoh, S., Inoue, K., Igarashi, K., Sugizaki, H., Shirode-Fukuda, Y., Inoue, E., Yu, T., Takeuchi, J., Kanno, J., Bonewald, L. F., et al. (2013) · Bone · doi:10.1016/j.bone.2013.12.005 · Cited by 119 · see citing works
Fliniaux, I., Mikkola, M. L., Lefebvre, S., & Thesleff, I. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.04.023 · Cited by 117 · see citing works
Making up the numbers: The molecular control of mammalian dental formula
Cobourne, M. T., & Sharpe, P. T. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.01.007 · Cited by 119 · see citing works
Sclerostin: A gem from the genome leads to bone-building antibodies
Pászty, C., Turner, C. H., & Robinson, M. K. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.161 · Cited by 118 · see citing works
Targeting Wnt Pathways in DiseasePreprint
Zimmerman, Z. F., Moon, R. T., & Chien, A. J. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008086 · Cited by 112 · see citing works
Korvala, J., Jüppner, H., Mäkitie, O., Sochett, E. B., Schnabel, D., Mora, S., Bartels, C. F., Warman, M. L., Deraska, D. J., Cole, W. G., et al. (2012) · BMC Medical Genetics · doi:10.1186/1471-2350-13-26 · Cited by 110 · see citing works
Molecular mechanisms of inflammatory bone damage: emerging targets for therapy
Herman, S., Krönke, G., & Schett, G. A. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.04.001 · Cited by 108 · see citing works
Munne, P., Tümmers, M., Järvinen, E., Thesleff, I., & Jernvall, J. (2009) · Development · doi:10.1242/dev.025064 · Cited by 105 · see citing works
Mapping Canonical Wnt Signaling in the Developing and Adult Retina
Liu, H., Thurig, S., Mohamed, O. A., Dufort, D., & Wallace, V. A. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0403 · Cited by 105 · see citing works
Role of CCN, a vertebrate specific gene family, in development
Katsube, K., Sakamoto, K., Tamamura, Y., & Yamaguchi, A. (2008) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01077.x · Cited by 103 · see citing works
Ectodysplasin A (EDA) – EDA receptor signalling and its pharmacological modulation
Kowalczyk-Quintas, C., & Schneider, P. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.01.004 · Cited by 97 · see citing works
Dickkopf1: A tumor suppressor or metastasis promoter?
Menezes, M. E., Devine, D. J., Shevde, L. A., & Samant, R. S. (2011) · International Journal of Cancer · doi:10.1002/ijc.26449 · Cited by 95 · see citing works
- Authors
- Itasaki, N., Jones, C. M., Mercurio, S., Rowe, A., Domingos, P. M., Smith, J. C., & Krumlauf, R.
- Affiliations
- National Institute for Medical Research (GB)
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-09-15
- Volume
- 130
- Issue
- 18
- Pages
- 4295-4305
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2095537830
- Cited by
- 321
- References
- 72
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 14 · 2019: 8 · 2018: 10 · 2017: 14 · 2016: 14 · 2015: 10 · 2014: 14 · 2013: 20 · 2012: 20
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion, other-oa)
- Bristol Research (University of Bristol) (submittedVersion, other-oa)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- WISE, Wnt signaling, canonical Wnt pathway, LRP6, Wnt8, β-catenin nuclear accumulation, secreted proteins, anterior-posterior patterning, neural induction
- MeSH terms
- Noggin Protein, Amino Acid Sequence, Animals, Carrier Proteins, Cytoskeletal Proteins, Embryonic Induction, Humans, Molecular Sequence Data, Morphogenesis, Phenotype, Proteins, Proto-Oncogene Proteins, Receptors, LDL, Xenopus laevis, Signal Transduction, Biomarkers, Trans-Activators, Oligonucleotides, Antisense, Sequence Alignment, Cell Polarity, In Situ Hybridization, Activins, Xenopus Proteins, Zebrafish Proteins, Wnt Proteins, beta Catenin, Low Density Lipoprotein Receptor-Related Protein-6
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review