The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Extensive Diversity of Ig-Superfamily Proteins in the Immune System of Insects
Abstract
The extensive somatic diversification of immune receptors is a hallmark of higher vertebrates. However, whether molecular diversity contributes to immune protection in invertebrates is unknown. We present evidence that Drosophila immune-competent cells have the potential to express more than 18,000 isoforms of the immunoglobulin (Ig)-superfamily receptor Down syndrome cell adhesion molecule (Dscam). Secreted protein isoforms of Dscam were detected in the hemolymph, and hemocyte-specific loss of Dscam impaired the efficiency of phagocytic uptake of bacteria, possibly due to reduced bacterial binding. Importantly, the molecular diversity of Dscam transcripts generated through a mechanism of alternative splicing is highly conserved across major insect orders, suggesting an unsuspected molecular complexity of the innate immune system of insects.
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Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity
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Self-citationFunctional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
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Signaling Role of Hemocytes in Drosophila JAK/STAT-Dependent Response to Septic Injury
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Diversification of Ig Superfamily Genes in an Invertebrate
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Drosophila Scavenger Receptor CI Is a Pattern Recognition Receptor for Bacteria
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The Host Defense of Drosophila melanogaster
Lemaitre, B., & Hoffmann, J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141615 · Cited by 3,324
The Evolution of Adaptive Immune Systems
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The immune gene repertoire encoded in the purple sea urchin genome
Hibino, T., Loza-Coll, M., Messier, C., Majeske, A. J., Cohen, A. H., Terwilliger, D. P., Buckley, K. M., Brockton, V., Nair, S. V., Berney, K., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.065 · Cited by 630
Immune proteins in brain development and synaptic plasticity
Boulanger, L. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.001 · Cited by 555
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Metadata
- Authors
- Watson, F. L., Püttmann-Holgado, R., Thomas, F., Lamar, D. L., Hughes, M., Kondo, M., Rebel, V. I., & Schmucker, D.
- Venue
- Science
- Published
- 2005-09-16
- Volume
- 309
- Issue
- 5742
- Pages
- 1874-1878
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2066753890
- Cited by
- 686
- References
- 22
- FWCI
- 14.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Watson, F. L., Püttmann-Holgado, R., Thomas, F., Lamar, D. L., Hughes, M., Kondo, M., Rebel, V. I., & Schmucker, D. (2005). Extensive Diversity of Ig-Superfamily Proteins in the Immune System of Insects. Science. https://doi.org/10.1126/science.1116887
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