Cited by 1,107Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

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Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

Nisoli, Enzo, Tonello, Cristina, Cardile, Annalisa, Cozzi, Valeria, Bracale, Renata, Tedesco, Laura, Falcone, Sestina, Valerio, Alessandra, Cantoni, Orazio, Clementi, Emilio, Moncada, Salvador, Carruba, Michele O.·2005·Science

DOI 10.1126/science.1117728

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Abstract

Calorie restriction extends life span in organisms ranging from yeast to mammals. Here, we report that calorie restriction for either 3 or 12 months induced endothelial nitric oxide synthase (eNOS) expression and 3',5'-cyclic guanosine monophosphate formation in various tissues of male mice. This was accompanied by mitochondrial biogenesis, with increased oxygen consumption and adenosine triphosphate production, and an enhanced expression of sirtuin 1. These effects were strongly attenuated in eNOS null-mutant mice. Thus, nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals.

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Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science · doi:10.1126/science.1099196 · Cited by 1,924
Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S., et al. (2003) · Science · doi:10.1126/science.1079368 · Cited by 1,243
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
Blüher, M., Kahn, B. B., & Kahn, C. R. (2003) · Science · doi:10.1126/science.1078223 · Cited by 1,155
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Lin, S.-J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P.-A., Culotta, V. C., Fink, G. R., & Guarente, L. (2002) · Nature · doi:10.1038/nature00829 · Cited by 1,057
Structural Basis of Mitochondrial Tethering by Mitofusin Complexes
Koshiba, T., Detmer, S. A., Kaiser, J. T., Chen, H., McCaffery, J. M., & Chan, D. C. (2004) · Science · doi:10.1126/science.1099793 · Cited by 910

Show all 26 references

Research works printed but not linked: 2

Y. Higami et al., FASEB J.18, 415 (2004).
S. Cook et al., Swiss Med. Wkly.133, 360 (2003).

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Background
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Background
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277
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Background
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Background
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Anti-aging activity of Korean pine ( Pinus koraiensis ) leaf extracts demonstrated through the induction of mitochondrial biogenesis in mice
Lee, M. Y., Kim, H., Chae, S., Uddin, M. R., Lee, H. W., Choi, G., Kim, Y. H., Im, A., & Kang, B. J. (2013) · Journal of Medicinal Plants Research · Cited by 1
Does SIRT-1 Mediate Calorie Restriction and Prolong Life?
Kordala, A. J., & Pietrzak, B. (2014) · Polish Journal of Food and Nutrition Sciences · doi:10.2478/pjfns-2013-0011 · Cited by 1
Advances in Sirtuin on The Mechanism of Calorie Restriction on Lifespan*
Liu, B., Chen, W., Liu, X., & Zhou, Z. (2012) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2011.00146 · Cited by 1
Type 2 diabetes mellitus, drug addiction, bipolar disorder and epilepsy display overlapping aetiopathogenic mechanisms: Implication for prevention and pharmacotherapy
Oriaifo, S. E. (2015) · International Research Journal of Medicine and Medical Sciences · doi:10.14303/jmms.2015.116 · Cited by 1
“…defective endothelial nitric oxide signalling (Sartori and Scherrer, 1999) is a hall-mark of the high cardiovascular risk in the metabolic syndrome (Nisoli et al., 2007; 2005; 2003; Patel et al., 2000; Jobgen et al., 2006; Joseph et al., 2012); epilepsy (Waldbaum and Patel, 2010; Martinc et al.,…”
Background
Sirtuins - the regulators of lifespan.
Kalmath, G. P., Swamy, M. N., & Veena, T. (2014) · Wayamba Journal of Animal Science · Cited by 1
Mitochondrial Dysfunction in Metabolic Disease
Meiliana, A., & Wijaya, A. (2012) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v4i3.172 · Cited by 1
HEART AND AGE (PART III): MODIFYING AGEING PROCESSES
Akasheva, D. U., Владимировна, П. Е., Strazhesko, I. D., Dudinskaya, Е. N., & Tkacheva, O. N. (2013) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2013-5-91-96 · Cited by 1
The Impact of Ramadan Fasting on SIRT1 mRNA Expression in Peripheral Blood Mononuclear Cells
Molahoseini, M. H., Gorjipour, K., & Yeganeh, F. (2016) · Research in Molecular Medicine · doi:10.18869/acadpub.rmm.4.4.51 · Cited by 2
A novel caloric restriction mediator
Kobayashi, M., & Higami, Y. (2017) · Aging · doi:10.18632/aging.101311 · Cited by 1
Other Potential Functional Roles of ENOX Proteins
Morré, D. J., & Morré, D. M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3958-5_7 · Cited by 1
Yaşlanma Sürecinde Mitokondrinin Rolü
Çıracı, E., & Sezgin, S. B. A. (2020) · ICONTECH INTERNATIONAL JOURNAL · doi:10.46291/icontechvol4iss3pp1-10 · Cited by 1
ROLE OF CALCIUM AND NITRIC OXIDE SYNTHASE (NOS) IN BRAIN MITOCHONDRIAL DYSFUNCTION
Nukala, V. N. (2007) · UKnowledge (University of Kentucky) · Cited by 1
Drosophila Nicotinamidase And Sir2 In Longevity Regulation And Oxidative Stress Response, And The Implications For Aging Theory
Miller, G. S. (2010) · Human Biology · Cited by 1
Co-ativador de transcrição gênica PGC-1 na pancreatite aguda
Llimona, F. (2011) · doi:10.11606/t.5.2011.tde-20052011-174649 · Cited by 1
Developing a client-driven quality assurance program.
Prehn, R. A. (1990) · PubMed · Cited by 1
Is eternal youth scientifically plausible?
Hunter, P. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400876 · Cited by 1
Understanding the mechanisms of dietary restriction to extend healthy lifespan in Drosophila melanogaster.
Emran, S. (2015) · UCL Discovery (University College London) · Cited by 1
The Effect of Mitochondrial Biogenesis on Apoptotic Susceptibility in L6 Myoblasts
Dam, A. D. (2010) · UWSpace (University of Waterloo) · Cited by 1
Examining Autophagy and Mitophagy as Inducible Mechanisms of Cellular Remodelling
Bloemberg, D. (2017) · UWSpace (University of Waterloo) · Cited by 1
Study on the Role of SIRT2 in Stem Cell Aging and Chronic Inflammation
Luo, H. (2017) · eScholarship (California Digital Library) · Cited by 1
Metformin Collaborates With PINK1/Mfn2 Overexpression Prevented Isoproterenol-Induced Cardiomyocyte Injury By Improving Mitochondrial FunctionPreprint
Ma, Z., Liu, Z., Xue, Y., Zhang, H., Xiong, W., Zhou, H., Zeng, Q., Ren, H., & Xu, D. (2021) · Research Square · doi:10.21203/rs.3.rs-680629/v1 · Cited by 1
A familial natural short sleep mutation promotes healthy aging and extends lifespan in DrosophilaPreprint
Pandey, P., Wall, P. K., Lopez, S. R., Dubuisson, O. S., Zunica, E. R. M., Dantas, W. S., Kirwan, J. P., Axelrod, C. L., & Johnson, A. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.25.538137 · Cited by 1
Investigating the Synergistic effect of Leucine-Metformin-Sildenafil on Nonalcoholic Steatohepatitis
Fu, L. (2022) · Digital Archive @ GSU · doi:10.57709/7443898
Mitochondrial Respiratory Function Decline in Aging and Life-Span Extension by Caloric Restriction
Wu, S., Wu, Y., Wang, C., Lee, W., & Wei, Y. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-602-3_7
“Recently, it was demonstrated that the Sirt1 activity is required for CR-mediated activation of mitochondrial biogenesis and respiration in animals [130].”
Background
Biomarkers and Inflammatory Network in Aging
Balistreri, C. R., Acccardi, G., Caruso, C., & Candore, G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00001-0
“Furthermore, CR induces mitochondrial biogenesis, as measured by changes in mtDNA levels and protein levels [81].”
Background
The FoxO Transcription Factors and Sirtuins
Levine, T. B., & Levine, A. B. (2012) · Wiley eBooks · doi:10.1002/9781118480045.ch4

Authors: Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., Moncada, S., & Carruba, M. O.
Affiliations: University of Milan (IT)
Corresponding author: Nisoli, Enzo
ORCID: Nisoli, Enzo
Bracale, Renata
Tedesco, Laura
Falcone, Sestina
Valerio, Alessandra
Cantoni, Orazio
Clementi, Emilio
Moncada, Salvador
Carruba, Michele O.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2005-10-14
Volume: 310
Issue: 5746
Pages: 314-317
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1117728
OpenAlex: W2162306102
Cited by: 1,107
References: 26
Citations by year: 2026: 11 · 2025: 23 · 2024: 28 · 2023: 36 · 2022: 32 · 2021: 44 · 2020: 48 · 2019: 46 · 2018: 37 · 2017: 49 · 2016: 42 · 2015: 70 · 2014: 72 · 2013: 83 · 2012: 103
FWCI: 15.75
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: caloric restriction, mitochondrial biogenesis, endothelial nitric oxide synthase, nitric oxide, SIRT1, cyclic GMP, lifespan extension, oxygen consumption, ATP production
MeSH terms: Adipose Tissue, Animals, DNA, Mitochondrial, Enzyme Induction, Female, Life Expectancy, Male, Mice, Inbred C57BL, Mitochondria, Nitric Oxide, Oxygen Consumption, Protein Biosynthesis, Nitric Oxide Synthase, GTP Phosphohydrolases, Caloric Restriction, Sirtuins, Mice, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III, Sirtuin 1

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Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

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