The DOI matches its Crossref record.
Antagonistic Actions of Ecdysone and Insulins Determine Final Size in Drosophila
Abstract
All animals coordinate growth and maturation to reach their final size and shape. In insects, insulin family molecules control growth and metabolism, whereas pulses of the steroid 20-hydroxyecdysone (20E) initiate major developmental transitions. We show that 20E signaling also negatively controls animal growth rates by impeding general insulin signaling involving localization of the transcription factor dFOXO and transcription of the translation inhibitor 4E-BP . We also demonstrate that the larval fat body, equivalent to the vertebrate liver, is a key relay element for ecdysone-dependent growth inhibition. Hence, ecdysone counteracts the growth-promoting action of insulins, thus forming a humoral regulatory loop that determines organismal size.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 20
- E. Hafen, Curr. Top. Microbiol. Immunol.279, 153 (2004).
- 10.1016/S1534-5807(02)00117-X · DOI · Paper page
- 10.1016/S0092-8674(03)00713-X · DOI · Paper page
- L. M. Riddiford, Receptor3, 203 (1993).
- 10.1016/S0012-1606(03)00276-8 · DOI · Paper page
- 10.1016/S0960-9822(03)00197-0 · doi:10.1016/s0960-9822(03)00197-0
- 10.1242/dev.00460 · doi:10.1242/dev.00460
- 10.1006/scdb.1997.0172 · doi:10.1006/scdb.1997.0172
- 10.1016/j.ydbio.2005.02.028 · DOI
- 10.1101/gad.5.6.1067 · DOI
- 10.1242/dev.127.19.4115 · DOI · Paper page
- 10.1016/j.ibmb.2004.06.009 · DOI · Paper page
- 10.1016/S0092-8674(00)81512-3 · DOI · Paper page
- 10.1016/S0092-8674(00)80679-0 · DOI · Paper page
- 10.1186/1475-4924-2-20 · DOI · Paper page
- 10.1101/gad.1098703 · DOI · Paper page
- 10.1242/dev.00205 · DOI · Paper page
- 10.1126/science.1070058 · DOI · Paper page
- 10.1016/S0960-9822(02)01043-6 · DOI · Paper page
- 10.1016/j.devcel.2004.07.005 · DOI · Paper page
Cited by
Drosophila neuroblasts: a model for stem cell biology
Homem, C. C. F., & Knoblich, J. A. (2012) · Development · doi:10.1242/dev.080515 · Cited by 476
How flies get their size: genetics meets physiology
Edgar, B. A. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1989 · Cited by 441
Size and shape: the developmental regulation of static allometry in insects
Shingleton, A. W., Frankino, W. A., Flatt, T., Nijhout, H. F., & Emlen, D. J. (2007) · BioEssays · doi:10.1002/bies.20584 · Cited by 355
A Drosophila Insulin-like Peptide Promotes Growth during Nonfeeding States
Slaidina, M., Delanoue, R., Gronke, S., Partridge, L., & Léopold, P. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.10.009 · Cited by 353
Insulin/IGF-like signalling, the central nervous system and aging
Broughton, S., & Partridge, L. (2009) · Biochemical Journal · doi:10.1042/bj20082102 · Cited by 228
Metadata
- Authors
- Colombani, J., Bianchini, L., Layalle, S., Pondeville, E., Dauphin-Villemant, C., Antoniewski, C., Carré, C., Noselli, S., & Léopold, P.
- Venue
- Science
- Published
- 2005-10-28
- Volume
- 310
- Issue
- 5748
- Pages
- 667-670
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012257160
- Cited by
- 618
- References
- 0
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Antagonistic Actions of Ecdysone and Insulins Determine Final Size in Drosophila. https://app.cochat.ai/papers/10.1126/science.1119432
- The paper
- Colombani, J., Bianchini, L., Layalle, S., Pondeville, E., Dauphin-Villemant, C., Antoniewski, C., Carré, C., Noselli, S., & Léopold, P. (2005). Antagonistic Actions of Ecdysone and Insulins Determine Final Size in Drosophila. Science. https://doi.org/10.1126/science.1119432
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
