The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A Drosophila Insulin-like Peptide Promotes Growth during Nonfeeding States
Open accessAbstract
In metazoans, tissue growth relies on the availability of nutrients--stored internally or obtained from the environment--and the resulting activation of insulin/IGF signaling (IIS). In Drosophila, growth is mediated by seven Drosophila insulin-like peptides (Dilps), acting through a canonical IIS pathway. During the larval period, animals feed and Dilps produced by the brain couple nutrient uptake with systemic growth. We show here that, during metamorphosis, when feeding stops, a specific DILP (Dilp6) is produced by the fat body and relays the growth signal. Expression of DILP6 during pupal development is controlled by the steroid hormone ecdysone. Remarkably, DILP6 expression is also induced upon starvation, and both its developmental and environmental expression require the Drosophila FoxO transcription factor. This study reveals a specific class of ILPs induced upon metabolic stress that promotes growth in conditions of nutritional deprivation or following developmentally induced cessation of feeding.
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Cited by
The many faces of insulin-like peptide signalling in the brain
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Eat to reproduce: a key role for the insulin signaling pathway in adult insects
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Systemic corazonin signalling modulates stress responses and metabolism in Drosophila
Kubrak, O. I., Lushchak, O. V., Zandawala, M., & Nässel, D. R. (2016) · Open Biology · doi:10.1098/rsob.160152 · Cited by 134
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Metadata
- Authors
- Slaidina, M., Delanoue, R., Gronke, S., Partridge, L., & Léopold, P.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 17
- Issue
- 6
- Pages
- 874-884
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2048169326
- Cited by
- 353
- References
- 36
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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