The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Structure of a DNA Glycosylase Searching for Lesions
Abstract
DNA glycosylases must interrogate millions of base pairs of undamaged DNA in order to locate and then excise one damaged nucleobase. The nature of this search process remains poorly understood. Here we report the use of disulfide cross-linking (DXL) technology to obtain structures of a bacterial DNA glycosylase, MutM, interrogating undamaged DNA. These structures, solved to 2.0 angstrom resolution, reveal the nature of the search process: The protein inserts a probe residue into the helical stack and severely buckles the target base pair, which remains intrahelical. MutM therefore actively interrogates the intact DNA helix while searching for damage.
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Citations
Cites
Structure and Flexibility Adaptation in Nonspecific and Specific Protein-DNA Complexes
Kalodimos, C. G., Biris, N., Bonvin, A. M. J. J., Levandoski, M. M., Guennuegues, M., Boelens, R., & Kaptein, R. (2004) · Science · doi:10.1126/science.1097064 · Cited by 543
Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA
Banerjee, A., Yang, W., Karplus, M., & Verdine, G. L. (2005) · Nature · doi:10.1038/nature03458 · Cited by 346
Self-citation
Cited by
Endogenous DNA damage as a source of genomic instability in cancer
Tubbs, A., & Nussenzweig, A. (2017) · Cell · doi:10.1016/j.cell.2017.01.002 · Cited by 1,452
Base-excision repair of oxidative DNA damage
David, S. S., O'Shea, V. L., & Kundu, S. (2007) · Nature · doi:10.1038/nature05978 · Cited by 1,238
CRISPR-mediated adaptive immune systems in bacteria and archaea
Sorek, R., Lawrence, C. M., & Wiedenheft, B. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-072911-172315 · Cited by 668
Base excision repair and cancer
Wallace, S. S., Murphy, D. L., & Sweasy, J. B. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.12.038 · Cited by 329
Zharkov, D. O. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7543-2 · Cited by 310
Metadata
- Authors
- Banerjee, A., Santos, W. L., & Verdine, G. L.
- Venue
- Science
- Published
- 2006-02-24
- Volume
- 311
- Issue
- 5764
- Pages
- 1153-1157
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993859324
- Cited by
- 193
- References
- 2
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
