The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Methylation of tRNA Asp by the DNA Methyltransferase Homolog Dnmt2
Abstract
The sequence and the structure of DNA methyltransferase-2 (Dnmt2) bear close affinities to authentic DNA cytosine methyltransferases. A combined genetic and biochemical approach revealed that human DNMT2 did not methylate DNA but instead methylated a small RNA; mass spectrometry showed that this RNA is aspartic acid transfer RNA (tRNA Asp ) and that DNMT2 specifically methylated cytosine 38 in the anticodon loop. The function of DNMT2 is highly conserved, and human DNMT2 protein restored methylation in vitro to tRNA Asp from Dnmt2-deficient strains of mouse, Arabidopsis thaliana, and Drosophila melanogaster in a manner that was dependent on preexisting patterns of modified nucleosides. Indirect sequence recognition is also a feature of eukaryotic DNA methyltransferases, which may have arisen from a Dnmt2-like RNA methyltransferase.
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Cites
On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs
Santi, D. V., Garrett, C. E., & Barr, P. J. (1983) · Cell · doi:10.1016/0092-8674(83)90327-6 · Cited by 401
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Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M., & Lyko, F. (2010) · Genes & Development · doi:10.1101/gad.586710 · Cited by 746
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Chen, Q., Yan, W., & Duan, E. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.106 · Cited by 576
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Metadata
- Authors
- Goll, M. G., Kirpekar, F., Maggert, K. A., Yoder, J. A., Hsieh, C.-L., Zhang, X., Golic, K. G., Jacobsen, S. E., & Bestor, T. H.
- Venue
- Science
- Published
- 2006-01-20
- Volume
- 311
- Issue
- 5759
- Pages
- 395-398
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005311687
- Cited by
- 1,190
- References
- 1
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goll, M. G., Kirpekar, F., Maggert, K. A., Yoder, J. A., Hsieh, C.-L., Zhang, X., Golic, K. G., Jacobsen, S. E., & Bestor, T. H. (2006). Methylation of tRNA Asp by the DNA Methyltransferase Homolog Dnmt2. Science. https://doi.org/10.1126/science.1120976
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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