Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications
Open accessAbstract
Once deemed heretical, emerging evidence now supports the notion that the inheritance of acquired characteristics can occur through ancestral exposures or experiences and that certain paternally acquired traits can be 'memorized' in the sperm as epigenetic information. The search for epigenetic factors in mammalian sperm that transmit acquired phenotypes has recently focused on RNAs and, more recently, RNA modifications. Here, we review insights that have been gained from studying sperm RNAs and RNA modifications, and their roles in influencing offspring phenotypes. We discuss the possible mechanisms by which sperm become acquisitive following environmental-somatic-germline interactions, and how they transmit paternally acquired phenotypes by shaping early embryonic development.
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Long-lived RNA molecules appear to be less affected by these barriers and therefore more likely to carry epigenetic information across generations.
“Long-lived RNA molecules appear to be less affected by these barriers and therefore more likely to carry epigenetic information across generations4, although the mechanisms are largely unsolved.”
From A critical view on transgenerational epigenetic inheritance in humans (2018) · cites this paper as [4]
The Abstract (page unavailable) says non-coding RNAs can escape epigenetic reprogramming and that sperm RNAs can transfer acquired traits. The Sperm RNA modifications section (page unavailable) suggests that modifications increase tsRNA stability and may preserve its function after fertilization. It does not establish that long-lived RNA molecules generally are less affected by the barriers or more likely than shorter-lived RNAs to carry information across generations. (LLM, conf=0.85)
Experimental — accuracy not yet measuredNumerous reports on transgenerational responses to environmental or metabolic factors in mice and rats have been published in the past 10 years.
“In the past 10 years, numerous reports on transgenerational responses to environmental or metabolic factors in mice and rats have been published (for a comprehensive review, see refs. 4–7).”
From A critical view on transgenerational epigenetic inheritance in humans (2018) · cites this paper as [4]
The factors studied include endocrine disruptors, high fat diet, obesity, diabetes, undernourishment as well as trauma.
“The factors include endocrine disruptors, high fat diet, obesity, diabetes, undernourishment as well as trauma.”
From A critical view on transgenerational epigenetic inheritance in humans (2018) · cites this paper as [4]
DNA methylation was an early proposed carrier of epigenetic information, and later work showed chromatin proteins and noncoding RNAs also matter.
“DNA methylation was proposed early on as a carrier of epigenetic information with subsequent work revealing that chromatin proteins and noncoding RNAs are also important for this process [10][11][12][13][14] .”
From Advances in epigenetics link genetics to the environment and disease (2019) · cites this paper as [12]
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Advances in epigenetics link genetics to the environment and disease
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“It is now widely accepted that hereditary information in the germline can be encoded in other forms than merely DNA sequence 1, 7 .”
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- Authors
- Chen, Q., Yan, W., & Duan, E.
- Affiliations
- University of Nevada, Reno (US)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Chen, Qi
- Yan, Wei
- Duan, Enkui
- Venue
- Nature Reviews Genetics
- Published
- 2016-10-03
- Volume
- 17
- Issue
- 12
- Pages
- 733-743
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC5441558
- OpenAlex
- W2528415436
- Cited by
- 576
- References
- 140
- Citations by year
- 2026: 37 · 2025: 66 · 2024: 47 · 2023: 46 · 2022: 76 · 2021: 53 · 2020: 92 · 2019: 65 · 2018: 58 · 2017: 34 · 2016: 1
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (P30GM110767)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD071736, R01HD060858, R01HD085506)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- epigenetic inheritance, acquired characteristics, sperm RNA, RNA modification, paternal inheritance, environmental exposure, early embryonic development, transgenerational epigenetic inheritance
- MeSH terms
- Animals, Humans, Male, Phenotype, RNA, Spermatozoa, DNA Methylation, Inheritance Patterns, Epigenesis, Genetic
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