The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
SV2 Is the Protein Receptor for Botulinum Neurotoxin A
Abstract
How the widely used botulinum neurotoxin A (BoNT/A) recognizes and enters neurons is poorly understood. We found that BoNT/A enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C). Fragments of SV2 that harbor the toxin interaction domain inhibited BoNT/A from binding to neurons. BoNT/A binding to SV2A and SV2B knockout hippocampal neurons was abolished and was restored by expressing SV2A, SV2B, or SV2C. Reduction of SV2 expression in PC12 and Neuro-2a cells also inhibited entry of BoNT/A, which could be restored by expressing SV2 isoforms. Finally, mice that lacked an SV2 isoform (SV2B) displayed reduced sensitivity to BoNT/A. Thus, SV2 acts as the protein receptor for BoNT/A.
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Cites
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Botulinum Toxin as a Biological Weapon: Medical and Public Health Management
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Neurotoxins Affecting Neuroexocytosis
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Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
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Self-citationBuckley, K., & Kelly, R. B. (1985) · The Journal of cell biology · doi:10.1083/jcb.100.4.1284 · Cited by 712
Differential expression of synaptic vesicle protein 2 (SV2) isoforms
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Botulinum neurotoxins serotypes A and E cleave SNAP‐25 at distinct COOH‐terminal peptide bonds
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Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)
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How do tetanus and botulinum toxins bind to neuronal membranes?
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Cited by
Synaptophysin Regulates the Kinetics of Synaptic Vesicle Endocytosis in Central Neurons
Kwon, S. E., & Chapman, E. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.001 · Cited by 469
Self-citationJankovic, J. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70574-9 · Cited by 332
The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy
Heinen, F., Desloovere, K., Schroeder, A. S., Berweck, S., Borggraefe, I., van Campenhout, A., Andersen, G. L., Aydin, R., Becher, J. G., Bernert, G., et al. (2010) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2009.09.005 · Cited by 296
Biology and Genomic Analysis of Clostridium botulinum
Peck, M. W. (2009) · Advances in Microbial Physiology · doi:10.1016/s0065-2911(09)05503-9 · Cited by 275
SV2 Renders Primed Synaptic Vesicles Competent for Ca2+-Induced Exocytosis
Chang, W.-P., & Südhof, T. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4521-08.2009 · Cited by 176
Metadata
- Authors
- Dong, M., Yeh, F., Tepp, W. H., Dean, C., Johnson, E. A., Janz, R., & Chapman, E. R.
- Venue
- Science
- Published
- 2006-04-28
- Volume
- 312
- Issue
- 5773
- Pages
- 592-596
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090106870
- Cited by
- 770
- References
- 25
- FWCI
- 38.48
- Type
- journal article
- Language
- en
- Open access
- closed
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