The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Synaptophysin Regulates the Kinetics of Synaptic Vesicle Endocytosis in Central Neurons
Open accessAbstract
Summary Despite being the most abundant synaptic vesicle membrane protein, the function of synaptophysin remains enigmatic. For example, synaptic transmission was reported to be completely normal in synaptophysin knockout mice; however, direct experiments to monitor the synaptic vesicle cycle have not been carried out. Here, using optical imaging and electrophysiological experiments, we demonstrate that synaptophysin is required for kinetically efficient endocytosis of synaptic vesicles in cultured hippocampal neurons. Truncation analysis revealed that distinct structural elements of synaptophysin differentially regulate vesicle retrieval during and after stimulation. Thus, synaptophysin regulates at least two phases of endocytosis to ensure vesicle availability during and after sustained neuronal activity.
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Metadata
- Authors
- Kwon, S. E., & Chapman, E. R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 70
- Issue
- 5
- Pages
- 847-854
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2136916247
- Cited by
- 469
- References
- 43
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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