The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication
Abstract
Antibodies against nuclear self-antigens are characteristic of systemic autoimmunity, although mechanisms promoting their generation and selection are unclear. Here, we report that B cells containing the Y-linked autoimmune accelerator ( Yaa ) locus are intrinsically biased toward nucleolar antigens because of increased expression of TLR7, a single-stranded RNA-binding innate immune receptor. The TLR7 gene is duplicated in Yaa mice because of a 4-Megabase expansion of the pseudoautosomal region. These results reveal high divergence in mouse Y chromosomes and represent a good example of gene copy number qualitatively altering a polygenic disease manifestation.
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Cites
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Self-citationDefective B cell development and function in Btk-deficient mice
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Cited by
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304
Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895
Sex differences in immune responses
Klein, S. L., & Flanagan, K. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.90 · Cited by 6,370
Trex1 prevents cell-intrinsic initiation of autoimmunity
Stetson, D. B., Ko, J. S., Heidmann, T., & Medzhitov, R. (2008) · Cell · doi:10.1016/j.cell.2008.06.032 · Cited by 1,280
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
Gilliet, M., Cao, W., & Liu, Y.-J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2358 · Cited by 1,190
Metadata
- Authors
- Pisitkun, P., Deane, J. A., Difilippantonio, M. J., Tarasenko, T., Satterthwaite, A. B., & Bolland, S.
- Venue
- Science
- Published
- 2006-06-16
- Volume
- 312
- Issue
- 5780
- Pages
- 1669-1672
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2100706488
- Cited by
- 894
- References
- 20
- FWCI
- 42.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pisitkun, P., Deane, J. A., Difilippantonio, M. J., Tarasenko, T., Satterthwaite, A. B., & Bolland, S. (2006). Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication. Science. https://doi.org/10.1126/science.1124978
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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