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Structure of the Multidrug Transporter EmrD from Escherichia coli
Open accessAbstract
EmrD is a multidrug transporter from the Major Facilitator Superfamily that expels amphipathic compounds across the inner membrane of Escherichia coli . Here, we report the x-ray structure of EmrD determined to a resolution of 3.5 angstroms. The structure reveals an interior that is composed mostly of hydrophobic residues, which is consistent with its role transporting amphipathic molecules. Two long loops extend into the inner leaflet side of the cell membrane. This region can serve to recognize and bind substrate directly from the lipid bilayer. We propose that multisubstrate specificity, binding, and transport are facilitated by these loop regions and the internal cavity.
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Pao, S. S., Paulsen, I. T., & Saier, M. H. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.1-34.1998 · Cited by 2,297
Kasianowicz, J., Benz, R., & McLaughlin, S. (1984) · The Journal of Membrane Biology · doi:10.1007/bf01868942 · Cited by 191
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Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328
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Thorens, B., & Mueckler, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00712.2009 · Cited by 1,013
Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations
Sun, J., Deng, Z., & Yan, A. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.05.090 · Cited by 746
Ins and Outs of Major Facilitator Superfamily Antiporters
Law, C. J., Maloney, P. C., & Wang, D.-N. (2008) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093329 · Cited by 498
Metadata
- Authors
- Yin, Y., He, X., Szewczyk, P., Nguyen, T., & Chang, G.
- Venue
- Science
- Published
- 2006-05-05
- Volume
- 312
- Issue
- 5774
- Pages
- 741-744
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1912107272
- Cited by
- 387
- References
- 2
- FWCI
- 12.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Yin, Y., He, X., Szewczyk, P., Nguyen, T., & Chang, G. (2006). Structure of the Multidrug Transporter EmrD from Escherichia coli. Science. https://doi.org/10.1126/science.1125629
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
