The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ischemia Opens Neuronal Gap Junction Hemichannels
Abstract
Neuronal excitotoxicity during stroke is caused by activation of unidentified large-conductance channels, leading to swelling and calcium dysregulation. We show that ischemic-like conditions [O 2 /glucose deprivation (OGD)] open hemichannels, or half gap junctions, in neurons. Hemichannel opening was indicated by a large linear current and flux across the membrane of small fluorescent molecules. Single-channel openings of hemichannels (530 picosiemens) were observed in OGD. Both the current and dye flux were blocked by inhibitors of hemichannels. Therefore, hemichannel opening contributes to the profound ionic dysregulation during stroke and may be a ubiquitous component of ischemic neuronal death.
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Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
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Cited by
Dreier, J. P. (2011) · Nature Medicine · doi:10.1038/nm.2333 · Cited by 1,132
Targeting NMDA receptors in stroke: new hope in neuroprotection
Wu, Q. J., & Tymianski, M. (2018) · Molecular Brain · doi:10.1186/s13041-018-0357-8 · Cited by 319
Activation of Neuronal NMDA Receptors Triggers Transient ATP-Mediated Microglial Process Outgrowth
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“Perhaps, in vitro studies of ischemia showing increased membrane permeability (Thompson et al., 2006) model relatively later stage in vivo events that reflect delayed membrane breakdown (that we observe in some animals after 40 min) and possibly precede cell death.”
Background
Metadata
- Authors
- Thompson, R. J., Zhou, N., & MacVicar, B. A.
- Venue
- Science
- Published
- 2006-05-12
- Volume
- 312
- Issue
- 5775
- Pages
- 924-927
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995256270
- Cited by
- 560
- References
- 1
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thompson, R. J., Zhou, N., & MacVicar, B. A. (2006). Ischemia Opens Neuronal Gap Junction Hemichannels. Science. https://doi.org/10.1126/science.1126241
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
