The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
Targeting NMDA receptors in stroke: new hope in neuroprotection
Open accessAbstract
NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be translated into clinical stroke treatments. However, recent research on NMDAR-associated signaling complexes has identified important death-signaling pathways linked to NMDARs. This led to the generation of inhibitors that inhibit these pathways downstream from the receptor without necessarily blocking NMDARs. This therapeutic approach may have fewer side effects and/or provide a wider therapeutic window for stroke as compared to the receptor antagonists. In this review, we highlight the key findings in the signaling cascades downstream of NMDARs and the novel promising therapeutics for ischemic stroke.
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Cited by
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
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A Neurotoxic Ménage-à-trois: Glutamate, Calcium, and Zinc in the Excitotoxic Cascade
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Metadata
- Authors
- Wu, Q. J., & Tymianski, M.
- Venue
- Molecular Brain
- Published
- 2018-03-13
- Volume
- 11
- Issue
- 1
- Pages
- 15-15
- ISSN
- 1756-6606 (ISSN-L)
- OpenAlex
- W2800776893
- Cited by
- 319
- References
- 150
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- gold
- Licence
- creativecommons.org/licenses/by/4.0/ (tdm)
- Funders
- Canada Research Chairs program
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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