Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 782

The DOI matches its Crossref record.

A Key Role for TRPM7 Channels in Anoxic Neuronal Death

Open access
Aarts, Michelle, Iihara, Koji, Wei, Wen-Li, Xiong, Zhi-Gang, Arundine, Mark, Cerwinski, Waldy, MacDonald, John F., Tymianski, Michael·2003·Cell
DOI 10.1016/s0092-8674(03)01017-1
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(03)01017-1

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 43

  1. Aarts, 2002, Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions, Science, 298, 846, 10.1126/science.1072873 · DOI · Paper page
  2. Birmingham, 2002, Future of neuroprotective drugs in doubt, Nat. Med., 8, 5, 10.1038/nm0102-5a · doi:10.1038/nm0102-5a
  3. Budd, 1996, A reevaluation of the role of mitochondria in neuronal Ca2+ homeostasis, J. Neurochem., 66, 403, 10.1046/j.1471-4159.1996.66010403.x · DOI · Paper page
  4. Choi, 1998, Zinc and brain injury, Annu. Rev. Neurosci., 21, 347, 10.1146/annurev.neuro.21.1.347 · DOI · Paper page
  5. Choi, 1987, Glutamate neurotoxicity in cortical cell culture, J. Neurosci., 7, 357, 10.1523/JNEUROSCI.07-02-00357.1987 · DOI · Paper page
  6. Cullen, 2002, RNA interference, Nat. Immunol., 3, 597, 10.1038/ni0702-597 · DOI
  7. Davis, 1997, Termination of acute stroke studies involving selfotel treatment, ASSIST Steering Committed. Lancet, 349, 32
  8. Dugan, 1995, Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate, J. Neurosci., 15, 6377, 10.1523/JNEUROSCI.15-10-06377.1995 · DOI · Paper page
  9. Elbashir, 2001, Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells, Nature, 411, 494, 10.1038/35078107 · DOI · Paper page
  10. Gao, 1998, Prolonged enhancement and depression of synaptic transmission in CA1 pyramidal neurons induced by transient forebrain ischemia in vivo, Neuroscience, 87, 371, 10.1016/S0306-4522(98)00150-X · DOI · Paper page
  11. Goldberg, 1993, Combined oxygen and glucose deprivation in cortical cell culture, J. Neurosci., 13, 3510, 10.1523/JNEUROSCI.13-08-03510.1993 · DOI · Paper page
  12. Goldberg, 1987, N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture, J. Pharmacol. Exp. Ther., 243, 784
  13. Golovina, 1997, Spatially and functionally distinct Ca2+ stores in sarcoplasmic and endoplasmic reticulum, Science, 275, 1643, 10.1126/science.275.5306.1643 · DOI · Paper page
  14. Hara, 2002, LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death, Mol. Cell, 9, 163, 10.1016/S1097-2765(01)00438-5 · DOI · Paper page
  15. Ikonomidou, 2002, Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?, Lancet Neurol., 1, 383, 10.1016/S1474-4422(02)00164-3 · DOI · Paper page
  16. Kerschbaum, 2003, Polyvalent cations as permeant probes of MIC and TRPM7 pores, Biophys. J., 84, 2293, 10.1016/S0006-3495(03)75035-8 · DOI
  17. Kozak, 2003, MIC channels are inhibited by internal divalent cations but not ATP, Biophys. J., 84, 922, 10.1016/S0006-3495(03)74909-1 · DOI
  18. Lees, 2000, Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke, Lancet, 355, 1949, 10.1016/S0140-6736(00)02326-6 · DOI · Paper page
  19. Lipton, 1999, Ischemic cell death in brain neurons, Physiol. Rev., 79, 1431, 10.1152/physrev.1999.79.4.1431 · DOI · Paper page
  20. Lipton, 1994, Excitatory amino acids as a final common pathway for neurologic disorders, N. Engl. J. Med., 330, 613, 10.1056/NEJM199403033300907 · DOI · Paper page
  21. Monteilh-Zoller, 2003, TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions, J. Gen. Physiol., 121, 49, 10.1085/jgp.20028740 · DOI · Paper page
  22. Montell, 2002, The TRP channels, a remarkably functional family, Cell, 108, 595, 10.1016/S0092-8674(02)00670-0 · DOI · Paper page
  23. Morris, 1999, Failure of the competitive N-methyl-D-aspartate antagonist selfotel (CGS 19755) in the treatment of severe head injury, J. Neurosurg., 91, 737, 10.3171/jns.1999.91.5.0737 · DOI · Paper page
  24. Nadler, 2001, LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability, Nature, 411, 590, 10.1038/35079092 · DOI · Paper page
  25. Olney, 1969, Brain lesion, obesity and other disturbances in mice treated with monosodium glutamate, Science, 164, 719, 10.1126/science.164.3880.719 · DOI · Paper page
  26. Patel, 1996, Requirement for superoxide in excitotoxic cell death, Neuron, 16, 345, 10.1016/S0896-6273(00)80052-5 · DOI · Paper page
  27. Perraud, 2003, TRPM2 Ca2+ permeable cation channels, Cell Calcium, 33, 519, 10.1016/S0143-4160(03)00057-5 · DOI · Paper page
  28. Rossi, 2000, Glutamate release in severe brain ischaemia is mainly by reversed uptake, Nature, 403, 316, 10.1038/35002090 · DOI · Paper page
  29. Runnels, 2001, TRP-PLIK, a bifunctional protein with kinase and ion channel activities, Science, 291, 1043, 10.1126/science.1058519 · DOI · Paper page
  30. Runnels, 2002, The TRPM7 channel is inactivated by PIP(2) hydrolysis, Nat. Cell Biol., 4, 329, 10.1038/ncb781 · DOI · Paper page
  31. Sattler, 1997, Determination of the time-course and extent of neurotoxicity at defined temperatures in cultured neurons using a modified multi-well plate fluorescence scanner, J. Cereb. Blood Flow Metab., 17, 455, 10.1097/00004647-199704000-00011 · DOI
  32. Sattler, 1998, Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity, J. Neurochem., 71, 2349, 10.1046/j.1471-4159.1998.71062349.x · DOI · Paper page
  33. Sattler, 1999, Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein, Science, 284, 1845, 10.1126/science.284.5421.1845 · DOI · Paper page
  34. Schmitz, 2003, Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7, Cell, 114, 191, 10.1016/S0092-8674(03)00556-7 · DOI · Paper page
  35. Sensi, 1999, Glutamate triggers preferential Zn2+ flux through Ca2+ permeable AMPA channels and consequent ROS production, Neuroreport, 10, 1723, 10.1097/00001756-199906030-00018 · DOI
  36. Sheline, 2002, Depolarization-induced 65zinc influx into cultured cortical neurons, Neurobiol. Dis., 10, 41, 10.1006/nbdi.2002.0497 · DOI
  37. Simon, 1984, Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain, Science, 226, 850, 10.1126/science.6093256 · DOI · Paper page
  38. Strubing, 2003, Formation of novel TRPC channels by complex subunit interactions in embryonic brain, J. Biol. Chem., 278, 39014, 10.1074/jbc.M306705200 · DOI · Paper page
  39. Tymianski, 1993, Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons, J. Neurosci., 13, 2085, 10.1523/JNEUROSCI.13-05-02085.1993 · DOI · Paper page
  40. Wehage, 2002, Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose, J. Biol. Chem., 277, 23150, 10.1074/jbc.M112096200 · DOI · Paper page
  41. Weiss, 1993, AMPA receptor activation potentiates zinc neurotoxicity, Neuron, 10, 43, 10.1016/0896-6273(93)90240-R · DOI · Paper page
  42. Xiong, 1997, Extracellular calcium sensed by a novel cation channel in hippocampal neurons, Proc. Natl. Acad. Sci. USA, 94, 7012, 10.1073/pnas.94.13.7012 · DOI
  43. Ying, 2000, Differing effects of copper, zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins, J. Cereb. Blood Flow Metab., 20, 359, 10.1097/00004647-200002000-00018 · DOI

Cited by

See all 782

Metadata

Authors
Aarts, M., Iihara, K., Wei, W.-L., Xiong, Z.-G., Arundine, M., Cerwinski, W., MacDonald, J. F., & Tymianski, M.
Venue
Cell
Publisher
Elsevier BV
Published
2003-12
Volume
115
Issue
7
Pages
863-877
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/s0092-8674(03)01017-1
OpenAlex
W2066581734
Cited by
782
References
0
FWCI
15.56
Type
journal article
Language
en
Open access
bronze
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: A Key Role for TRPM7 Channels in Anoxic Neuronal Death. https://app.cochat.ai/papers/10.1016/s0092-8674(03)01017-1
The paper
Aarts, M., Iihara, K., Wei, W.-L., Xiong, Z.-G., Arundine, M., Cerwinski, W., MacDonald, J. F., & Tymianski, M. (2003). A Key Role for TRPM7 Channels in Anoxic Neuronal Death. Cell. https://doi.org/10.1016/s0092-8674(03)01017-1

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.