The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures
Open accessAbstract
The treelike structures of many organs, including the mammary gland, are generated by branching morphogenesis, a reiterative process of branch initiation and invasion from a preexisting epithelium. Using a micropatterning approach to control the initial three-dimensional structure of mouse mammary epithelial tubules in culture, combined with an algorithm to quantify the extent of branching, we found that the geometry of tubules dictates the position of branches. We predicted numerically and confirm experimentally that branches initiate at sites with a local minimum in the concentration of autocrine inhibitory morphogens, such as transforming growth factor–β. These results reveal that tissue geometry can control organ morphogenesis by defining the local cellular microenvironment, a finding that has relevance to control of invasion and metastasis.
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Cites
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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
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Self-citationCRICK, F. (1970) · Nature · doi:10.1038/225420a0 · Cited by 907
Emergent patterns of growth controlled by multicellular form and mechanics
Nelson, C. M., Jean, R. P., Tan, J. L., Liu, W. F., Sniadecki, N. J., Spector, A. A., & Chen, C. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502575102 · Cited by 853
Self-citationFibronectin requirement in branching morphogenesis
Sakai, T., Larsen, M., & Yamada, K. M. (2003) · Nature · doi:10.1038/nature01712 · Cited by 551
Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis
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Genetic Control of Branching Morphogenesis
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Metadata
- Authors
- Nelson, C. M., VanDuijn, M. M., Inman, J. L., Fletcher, D. A., & Bissell, M. J.
- Venue
- Science
- Published
- 2006-10-13
- Volume
- 314
- Issue
- 5797
- Pages
- 298-300
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1996187477
- Cited by
- 608
- References
- 28
- FWCI
- 11.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Nelson, C. M., VanDuijn, M. M., Inman, J. L., Fletcher, D. A., & Bissell, M. J. (2006). Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures. Science. https://doi.org/10.1126/science.1131000
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
