The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Genetic Control of Branching Morphogenesis
Abstract
The genetic programs that direct formation of the treelike branching structures of two animal organs have begun to be elucidated. In both the developing Drosophila tracheal (respiratory) system and mammalian lung, a fibroblast growth factor (FGF) signaling pathway is reiteratively used to pattern successive rounds of branching. The initial pattern of signaling appears to be established by early, more global embryonic patterning systems. The FGF pathway is then modified at each stage of branching by genetic feedback controls and other signals to give distinct branching outcomes. The reiterative use of a signaling pathway by both insects and mammals suggests a general scheme for patterning branching morphogenesis.
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Klämbt, C. (1993) · Development · doi:10.1242/dev.117.1.163 · Cited by 332
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1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures
Nelson, C. M., VanDuijn, M. M., Inman, J. L., Fletcher, D. A., & Bissell, M. J. (2006) · Science · doi:10.1126/science.1131000 · Cited by 608
Building epithelial architecture: insights from three-dimensional culture models
O'Brien, L. E., Zegers, M. M. P., & Mostov, K. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm859 · Cited by 596
Programmed and self-organized flow of information during morphogenesis
Collinet, C., & Lecuit, T. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00318-6 · Cited by 322
Metadata
- Authors
- Metzger, R. J., & Krasnow, M. A.
- Venue
- Science
- Published
- 1999-06-04
- Volume
- 284
- Issue
- 5420
- Pages
- 1635-1639
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086200882
- Cited by
- 497
- References
- 1
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Metzger, R. J., & Krasnow, M. A. (1999). Genetic Control of Branching Morphogenesis. Science. https://doi.org/10.1126/science.284.5420.1635
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
