The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock
Abstract
The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the segmentation clock, drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the notch–fibroblast growth factor and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.
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“When comparing Fig 6 and S1 Fig, we find that the wet-lab data from just three studies, namely from [105–107], have been reused by simulation studies.”
From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [107]
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A High-Resolution Root Spatiotemporal Map Reveals Dominant Expression Patterns
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Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors
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Oscillating Gene Expression Determines Competence for Periodic Arabidopsis Root Branching
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Metadata
- Authors
- Dequéant, M.-L., Glynn, E., Gaudenz, K., Wahl, M., Chen, J., Mushegian, A., & Pourquié, O.
- Affiliations
- Howard Hughes Medical Institute, Kansas City, MO 64110, USA.
- Stowers Institute for Medical Research (US)
- Venue
- Science
- Published
- 2006-12-08
- Volume
- 314
- Issue
- 5805
- Pages
- 1595-1598
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068329746
- Cited by
- 460
- References
- 21
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 18 · 2023: 9 · 2022: 17 · 2021: 21 · 2020: 17 · 2019: 20 · 2018: 17 · 2017: 12 · 2016: 19 · 2015: 22 · 2014: 20 · 2013: 23 · 2012: 34
- FWCI
- 18.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- segmentation clock, presomitic mesoderm, somitogenesis, cyclic gene expression, Notch signaling, FGF signaling, Wnt signaling, signaling pathways, mouse embryo, vertebral segmentation
- MeSH terms
- Algorithms, Animals, Fibroblast Growth Factors, Multigene Family, Hybrid Cells, Mesoderm, Transcription, Genetic, Signal Transduction, Glycosyltransferases, Gene Expression Regulation, Developmental, Somites, Body Patterning, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MAP Kinase Signaling System, Embryonic Development, Wnt Proteins, Mice, Receptors, Notch
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