Cited by 460Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancerGenomics and Chromatin Dynamics

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A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock

Dequéant, Mary-Lee, Glynn, Earl, Gaudenz, Karin, Wahl, Matthias, Chen, Jie, Mushegian, Arcady, Pourquié, Olivier·2006·Science

DOI 10.1126/science.1133141

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Abstract

The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the segmentation clock, drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the notch–fibroblast growth factor and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.

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Authors: Dequéant, M.-L., Glynn, E., Gaudenz, K., Wahl, M., Chen, J., Mushegian, A., & Pourquié, O.
Affiliations: Howard Hughes Medical Institute, Kansas City, MO 64110, USA.
Stowers Institute for Medical Research (US)
ORCID: Chen, Jie
Mushegian, Arcady
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2006-12-08
Volume: 314
Issue: 5805
Pages: 1595-1598
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1133141
OpenAlex: W2068329746
Cited by: 460
References: 21
Citations by year: 2026: 7 · 2025: 12 · 2024: 18 · 2023: 9 · 2022: 17 · 2021: 21 · 2020: 17 · 2019: 20 · 2018: 17 · 2017: 12 · 2016: 19 · 2015: 22 · 2014: 20 · 2013: 23 · 2012: 34
FWCI: 18.64
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: segmentation clock, presomitic mesoderm, somitogenesis, cyclic gene expression, Notch signaling, FGF signaling, Wnt signaling, signaling pathways, mouse embryo, vertebral segmentation
MeSH terms: Algorithms, Animals, Fibroblast Growth Factors, Multigene Family, Hybrid Cells, Mesoderm, Transcription, Genetic, Signal Transduction, Glycosyltransferases, Gene Expression Regulation, Developmental, Somites, Body Patterning, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MAP Kinase Signaling System, Embryonic Development, Wnt Proteins, Mice, Receptors, Notch

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A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock

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