The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock
Abstract
The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the segmentation clock, drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the notch–fibroblast growth factor and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.
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“When comparing Fig 6 and S1 Fig, we find that the wet-lab data from just three studies, namely from [105–107], have been reused by simulation studies.”
From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [107]
Citations
Cites
Identification of c- MYC as a Target of the APC Pathway
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Wnt3a Plays a Major Role in the Segmentation Clock Controlling Somitogenesis
Aulehla, A., Wehrle, C., Brand‐Saberi, B., Kemler, R., Gossler, A., Kanzler, B., & Herrmann, B. G. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00055-8 · Cited by 593
The Segmentation Clock: Converting Embryonic Time into Spatial Pattern
Pourquié, O. (2003) · Science · doi:10.1126/science.1085887 · Cited by 530
Minowada, G., Jarvis, L. A., Chi, C. L., Neubüser, A., Sun, X., Hacohen, N., Krasnow, M. A., & Martin, G. R. (1999) · Development · doi:10.1242/dev.126.20.4465 · Cited by 506
c-Myc regulates mammalian body size by controlling cell number but not cell size
Trumpp, A., Refaeli, Y., Óskarsson, T., Gasser, S., Murphy, M., Martin, G. R., & Bishop, J. M. (2001) · Nature · doi:10.1038/414768a · Cited by 434
Dynamic Complex Formation During the Yeast Cell Cycle
de Lichtenberg, U., Jensen, L. J., Brunak, S., & Bork, P. (2005) · Science · doi:10.1126/science.1105103 · Cited by 405
Chamorro, M., Schwartz, D. R., Vonica, A., Brivanlou, A. H., Cho, K. R., & VARMUS, H. E. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600460 · Cited by 300
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A High-Resolution Root Spatiotemporal Map Reveals Dominant Expression Patterns
Brady, S. M., Orlando, D. A., Lee, J., Wang, J. Y., Koch, J. D., Dinneny, J. R., Mace, D., Ohler, U., & Benfey, P. N. (2007) · Science · doi:10.1126/science.1146265 · Cited by 1,154
Notch signaling pathway: architecture, disease, and therapeutics
Zhou, B., Lin, W., Long, Y., Yang, Y., Zhang, H., Wu, K., & Chu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00934-y · Cited by 1,216
Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors
Shimojo, H., Ohtsuka, T., & Kageyama, R. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.014 · Cited by 728
Oscillating Gene Expression Determines Competence for Periodic Arabidopsis Root Branching
Moreno-Risueno, M. Á., Norman, J. V., Moreno, A., Zhang, J., Ahnert, S. E., & Benfey, P. N. (2010) · Science · doi:10.1126/science.1191937 · Cited by 620
Therapeutic modulation of Notch signalling — are we there yet?
Andersson, E. R., & Lendahl, U. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4252 · Cited by 463
Metadata
- Authors
- Dequéant, M.-L., Glynn, E., Gaudenz, K., Wahl, M., Chen, J., Mushegian, A., & Pourquié, O.
- Affiliations
- Howard Hughes Medical Institute, Kansas City, MO 64110, USA.
- Stowers Institute for Medical Research (US)
- Venue
- Science
- Published
- 2006-12-08
- Volume
- 314
- Issue
- 5805
- Pages
- 1595-1598
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068329746
- Cited by
- 460
- References
- 21
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 18 · 2023: 9 · 2022: 17 · 2021: 21 · 2020: 17 · 2019: 20 · 2018: 17 · 2017: 12 · 2016: 19 · 2015: 22 · 2014: 20 · 2013: 23 · 2012: 34
- FWCI
- 18.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- segmentation clock, presomitic mesoderm, somitogenesis, cyclic gene expression, Notch signaling, FGF signaling, Wnt signaling, signaling pathways, mouse embryo, vertebral segmentation
- MeSH terms
- Algorithms, Animals, Fibroblast Growth Factors, Multigene Family, Hybrid Cells, Mesoderm, Transcription, Genetic, Signal Transduction, Glycosyltransferases, Gene Expression Regulation, Developmental, Somites, Body Patterning, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MAP Kinase Signaling System, Embryonic Development, Wnt Proteins, Mice, Receptors, Notch
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