The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication
Abstract
MicroRNAs (miRNAs) are single-stranded noncoding RNAs of 19 to 25 nucleotides that function as gene regulators and as a host cell defense against both RNA and DNA viruses. We provide evidence for a physiological role of the miRNA-silencing machinery in controlling HIV-1 replication. Type III RNAses Dicer and Drosha, responsible for miRNA processing, inhibited virus replication both in peripheral blood mononuclear cells from HIV-1–infected donors and in latently infected cells. In turn, HIV-1 actively suppressed the expression of the polycistronic miRNA cluster miR-17/92. This suppression was found to be required for efficient viral replication and was dependent on the histone acetyltransferase Tat cofactor PCAF. Our results highlight the involvement of the miRNA-silencing pathway in HIV-1 replication and latency.
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Cites
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Probing microRNAs with microarrays: tissue specificity and functional inference
BABAK, T., ZHANG, W., MORRIS, Q., BLENCOWE, B. J., & HUGHES, T. R. (2004) · RNA · doi:10.1261/rna.7119904 · Cited by 385
Cited by
LNA-mediated microRNA silencing in non-human primates
Elmén, J., Lindow, M., Schütz, S., Lawrence, M., Petri, A., Obad, S., Lindholm, M., Hedtjärn, M., Hansen, H. F., Berger, U., et al. (2008) · Nature · doi:10.1038/nature06783 · Cited by 1,589
Antiviral Immunity Directed by Small RNAs
Ding, S.-W., & Voinnet, O. (2007) · Cell · doi:10.1016/j.cell.2007.07.039 · Cited by 1,521
MicroRNAs in Development and Disease
Sayed, D., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,078
Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes
Huang, J., Wang, F., Argyris, E., Chen, K., Liang, Z., Tian, H., Huang, W., Squires, K., Verlinghieri, G., & Zhang, H. (2007) · Nature Medicine · doi:10.1038/nm1639 · Cited by 768
Viruses, microRNAs, and Host Interactions
Skalsky, R. L., & Cullen, B. R. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134243 · Cited by 676
Metadata
- Authors
- Triboulet, R., Mari, B., Lin, Y.-L., Chable-Bessia, C., Bennasser, Y., Lebrigand, K., Cardinaud, B., Maurin, T., Barbry, P., Baillat, V., Reynes, J., Corbeau, P., Jeang, K.-T., & Benkirane, M.
- Venue
- Science
- Published
- 2007-03-16
- Volume
- 315
- Issue
- 5818
- Pages
- 1579-1582
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976077409
- Cited by
- 628
- References
- 2
- FWCI
- 20.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Triboulet, R., Mari, B., Lin, Y.-L., Chable-Bessia, C., Bennasser, Y., Lebrigand, K., Cardinaud, B., Maurin, T., Barbry, P., Baillat, V., Reynes, J., Corbeau, P., Jeang, K.-T., & Benkirane, M. (2007). Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication. Science. https://doi.org/10.1126/science.1136319
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