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Multipotent Drosophila Intestinal Stem Cells Specify Daughter Cell Fates by Differential Notch Signaling
Abstract
The adult Drosophila midgut contains multipotent intestinal stem cells (ISCs) scattered along its basement membrane that have been shown by lineage analysis to generate both enterocytes and enteroendocrine cells. ISCs containing high levels of cytoplasmic Delta-rich vesicles activate the canonical Notch pathway and down-regulate Delta within their daughters, a process that programs these daughters to become enterocytes. ISCs that express little vesiculate Delta, or are genetically impaired in Notch signaling, specify their daughters to become enteroendocrine cells. Thus, ISCs control daughter cell fate by modulating Notch signaling over time. Our studies suggest that ISCs actively coordinate cell production with local tissue requirements by this mechanism.
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Cited by
Hogan, B. L. M., Barkauskas, C. E., Chapman, H. A., Epstein, J. A., Jain, R., Hsia, C. C. W., Niklason, L., Calle, E., Le, A., Randell, S. H., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.07.012 · Cited by 876
JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut
Biteau, B., Hochmuth, C. E., & Jasper, H. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.024 · Cited by 583
Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila
Buchon, N., Osman, D., David, F. P. A., Yu Fang, H., Boquete, J.-P., Deplancke, B., & Lemaitre, B. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.001 · Cited by 513
Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster
Miguel-Aliaga, I., Jasper, H., & Lemaitre, B. (2018) · Genetics · doi:10.1534/genetics.118.300224 · Cited by 491
Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel
He, L., Si, G., Huang, J., Samuel, A. D. T., & Perrimon, N. (2018) · Nature · doi:10.1038/nature25744 · Cited by 348
Metadata
- Authors
- Ohlstein, B., & Spradling, A.
- Venue
- Science
- Published
- 2007-02-16
- Volume
- 315
- Issue
- 5814
- Pages
- 988-992
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079657320
- Cited by
- 648
- References
- 0
- FWCI
- 12.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ohlstein, B., & Spradling, A. (2007). Multipotent Drosophila Intestinal Stem Cells Specify Daughter Cell Fates by Differential Notch Signaling. Science. https://doi.org/10.1126/science.1136606
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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