The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cadherin-11 in Synovial Lining Formation and Pathology in Arthritis
Abstract
The normal synovium forms a membrane at the edges of joints and provides lubrication and nutrients for the cartilage. In rheumatoid arthritis, the synovium is the site of inflammation, and it participates in an organized tissue response that damages cartilage and bone. We identified cadherin-11 as essential for the development of the synovium. Cadherin-11–deficient mice have a hypoplastic synovial lining, display a disorganized synovial reaction to inflammation, and are resistant to inflammatory arthritis. Cadherin-11 therapeutics prevent and reduce arthritis in mouse models. Thus, synovial cadherin-11 determines the behavior of synovial cells in their proinflammatory and destructive tissue response in inflammatory arthritis.
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TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.
Pettit, A. R., Ji, H., von Stechow, D., Müller, R., Goldring, S. R., Choi, Y., Benoist, C., & Gravallese, E. M. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63016-7 · Cited by 807
Osteoclasts are essential for TNF-α-mediated joint destruction.
Redlich, K., Hayer, S., Ricci, R., David, J.-P., Tohidast-Akrad, M., Kollias, G., Steiner, G., Smolen, J. S., Wagner, E. F., & Schett, G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215582 · Cited by 474
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease
Matsumoto, I., Maccioni, M., Lee, D. M., Maurice, M., Simmons, B., Brenner, M., Mathis, D., & Benoist, C. (2002) · Nature Immunology · doi:10.1038/ni772 · Cited by 329
Self-citation
Cited by
The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514
Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production
Boilard, E., Nigrovic, P. A., Larabee, K., Watts, G. F. M., Coblyn, J. S., Weinblatt, M. E., Massarotti, E. M., Remold-O’Donnell, E., Farndale, R. W., Ware, J., et al. (2010) · Science · doi:10.1126/science.1181928 · Cited by 1,085
Self-citationNotch signalling drives synovial fibroblast identity and arthritis pathology
Wei, K., Korsunsky, I., Marshall, J. L., Gao, A., Watts, G. F. M., Major, T., Croft, A. P., Watts, J., Blazar, P. E., Lange, J. K., et al. (2020) · Nature · doi:10.1038/s41586-020-2222-z · Cited by 528
Self-citationYang, Z., Shen, Y., Oishi, H., Matteson, E. L., Tian, L., Goronzy, J. J., & Weyand, C. M. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7151 · Cited by 275
Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1
Aikawa, Y., Morimoto, K., Yamamoto, T., Chaki, H., Hashiramoto, A., Narita, H., Hirono, S., & Shiozawa, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1412 · Cited by 214
Metadata
- Authors
- Lee, D. M., Kiener, H. P., Agarwal, S. K., Noss, E. H., Watts, G. F. M., Chisaka, O., Takeichi, M., & Brenner, M. B.
- Venue
- Science
- Published
- 2007-02-16
- Volume
- 315
- Issue
- 5814
- Pages
- 1006-1010
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077965112
- Cited by
- 420
- References
- 4
- FWCI
- 16.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, D. M., Kiener, H. P., Agarwal, S. K., Noss, E. H., Watts, G. F. M., Chisaka, O., Takeichi, M., & Brenner, M. B. (2007). Cadherin-11 in Synovial Lining Formation and Pathology in Arthritis. Science. https://doi.org/10.1126/science.1137306
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