The genomic basis of circadian and circalunar timing adaptations in a midge
Open accessAbstract
Organisms use endogenous clocks to anticipate regular environmental cycles, such as days and tides. Natural variants resulting in differently timed behaviour or physiology, known as chronotypes in humans, have not been well characterized at the molecular level. We sequenced the genome of Clunio marinus, a marine midge whose reproduction is timed by circadian and circalunar clocks. Midges from different locations show strain-specific genetic timing adaptations. We examined genetic variation in five C. marinus strains from different locations and mapped quantitative trait loci for circalunar and circadian chronotypes. The region most strongly associated with circadian chronotypes generates strain-specific differences in the abundance of calcium/calmodulin-dependent kinase II.1 (CaMKII.1) splice variants. As equivalent variants were shown to alter CaMKII activity in Drosophila melanogaster, and C. marinus (Cma)-CaMKII.1 increases the transcriptional activity of the dimer of the circadian proteins Cma-CLOCK and Cma-CYCLE, we suggest that modulation of alternative splicing is a mechanism for natural adaptation in circadian timing.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
One of the two QTLs linked to circalunar timing overlaps largely with one of the two circadian QTLs in Clunio marinus.
“Interestingly, one of the two quantitative trait loci (QTLs) linked to circalunar timing overlaps largely with one of the two circadian QTLs [46]”
From The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks (2020) · cites this paper as [46]
The mapping of all known genes with key roles in circadian timing or light input pathways revealed their complete absence from these QTLs in Clunio marinus.
“However, the mapping of all known genes with key roles in circadian timing or light input pathways revealed their complete absence from these QTLs [46]”
From The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks (2020) · cites this paper as [46]
Genetic linkage analysis identified two specific chromosomal regions responsible for diurnal emergence and two related to lunar timing in Clunio marinus.
“Genetic linkage analysis identified two specific chromosomal regions responsible for diurnal emergence and two related to lunar timing.”
From The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks (2020) · cites this paper as [46]
Current analysis in C. marinus is consistent with the idea that circadian and circalunar timing mechanisms are distinct, as none of the core circadian clock genes is involved in circalunar timing variation.
“Interestingly, the current analysis in the midge is consistent with the idea that circadian and circalunar timing mechanisms are distinct, as none of the core circadian clock genes is involved in circalunar timing variation (29).”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [29]
Combining genetic mapping of timing differences with a high-resolution genome and re-sequencing of distinct chronotypes has allowed identification of several candidate genes modulating circalunar (and circadian) timing in distinct C. marinus timing strains.
“Combining rigorous genetic mapping of these differences with a high-resolution genome for this insect, as well as re-sequencing of distinct chronotypes, has recently allowed the identification of several candidate genes modulating circalunar (and circadian) timing in distinct C. marinus timing strains (29).”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889 · see citing works
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895 · see citing works
A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526 · see citing works
Full-length transcriptome assembly from RNA-Seq data without a reference genome
Grabherr, M. G., Haas, B. J., Yassour, M., Levin, J. Z., Thompson, D. A., Amit, I., Adiconis, X., Fan, L., Raychowdhury, R., Zeng, Q., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1883 · Cited by 20,776 · see citing works
Cingolani, P., Platts, A., Wang, L. L., Coon, M., Nguyen, T., Wang, L., Land, S. J., Lu, X., & Ruden, D. M. (2012) · Fly · doi:10.4161/fly.19695 · Cited by 11,816 · see citing works
Circos: An information aesthetic for comparative genomicsPreprint
Krzywinski, M. I., Schein, J. E., Birol, İ., Connors, J. M., Gascoyne, R. D., Horsman, D. E., Jones, S. J. M., & Marra, M. A. (2009) · Genome Research · doi:10.1101/gr.092759.109 · Cited by 10,838 · see citing works
Velvet: Algorithms for de novo short read assembly using de Bruijn graphsPreprint
Zerbino, D. R., & Birney, E. (2008) · Genome Research · doi:10.1101/gr.074492.107 · Cited by 9,387 · see citing works
Crawley, M. J. (2007) · Medical Entomology and Zoology · Cited by 5,431 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Korf, I. F. (2004) · BMC Bioinformatics · doi:10.1186/1471-2105-5-59 · Cited by 3,160 · see citing works
DELLY: structural variant discovery by integrated paired-end and split-read analysis
Rausch, T., Zichner, T., Schlattl, A., Stütz, A. M., Beneš, V., & Korbel, J. O. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts378 · Cited by 2,384 · see citing works
Scaffolding pre-assembled contigs using SSPACE.
Boetzer, M., Henkel, C. V., Jansen, H. J., Butler, D., & Pirovano, W. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btq683 · Cited by 2,337 · see citing works
Holt, C., & Yandell, M. D. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-491 · Cited by 2,042 · see citing works
Insights into social insects from the genome of the honeybee Apis mellifera
Weinstock, G. M., Gibbs, R. A., Worley, K. C., Sodergren, E. J., Milosavljević, A., Richards, S., Miller, J., Jiang, H., Zhang, L., Wei, X., et al. (2006) · Nature · doi:10.1038/nature05260 · Cited by 1,871 · see citing works
Gene prediction with a hidden Markov model and a new intron submodel
Stanke, M., & Waack, S. (2003) · Bioinformatics · doi:10.1093/bioinformatics/btg1080 · Cited by 1,643 · see citing works
The genome of the model beetle and pest Tribolium castaneum
Richards, S., Gibbs, R. A., Weinstock, G. M., Gibbs, R. A., Muzny, D. M., Attaway, T., Bell, S., Buhay, C., Chandrabose, M. N., Chavez, D., et al. (2008) · Nature · doi:10.1038/nature06784 · Cited by 1,378 · see citing works
Toward almost closed genomes with GapFiller
Boetzer, M., & Pirovano, W. (2012) · Genome biology · doi:10.1186/gb-2012-13-6-r56 · Cited by 1,123 · see citing works
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055 · see citing works
Kofler, R., Pandey, R. V., & Schlötterer, C. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr589 · Cited by 815 · see citing works
Sun, P., Enslen, H., Myung, P. S., & Maurer, R. A. (1994) · Genes & Development · doi:10.1101/gad.8.21.2527 · Cited by 736 · see citing works
The Monarch Butterfly Genome Yields Insights into Long-Distance Migration
Zhan, S., Merlin, C., Boore, J. L., & Reppert, S. M. (2011) · Cell · doi:10.1016/j.cell.2011.09.052 · Cited by 586 · see citing works
Kofler, R., Orozco‐terWengel, P., Maio, N. D., Pandey, R. V., Nolte, V., Futschik, A., Kosiol, C., & Schlötterer, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015925 · Cited by 576 · see citing works
Zdobnov, E. M., von Mering, C., Letunic, I., Torrents, D., Suyama, M., Copley, R. R., Christophides, G. K., Thomasova, D., Holt, R. A., Subramanian, G. M., et al. (2002) · Science · doi:10.1126/science.1077061 · Cited by 553 · see citing works
Depression scores associate with chronotype and social jetlag in a rural population
Levandovski, R., Dantas, G., Fernandes, L. C., Caumo, W., Torres, I., Roenneberg, T., Hidalgo, M. P. L., & Allebrandt, K. V. (2011) · Chronobiology International · doi:10.3109/07420528.2011.602445 · Cited by 527 · see citing works
NextGenMap: fast and accurate read mapping in highly polymorphic genomes
Sedlazeck, F. J., Rescheneder, P., & von Haeseler, A. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt468 · Cited by 429 · see citing works
Self-citationCaMKII: Claiming Center Stage in Postsynaptic Function and Organization
Hell, J. W. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.024 · Cited by 352 · see citing works
Hu, Y., Shmygelska, A., Tran, D., Eriksson, N., Tung, J. Y., & Hinds, D. A. (2016) · Nature Communications · doi:10.1038/ncomms10448 · Cited by 321 · see citing works
Natural Variation in a Drosophila Clock Gene and Temperature Compensation
Sawyer, L., Hennessy, J. M., Peixoto, A. A., Rosato, E., Parkinson, H., Costa, R., & Kyriacou, C. P. (1997) · Science · doi:10.1126/science.278.5346.2117 · Cited by 320 · see citing works
Lane, J. M., Vlasac, I., Anderson, S. G., Kyle, S. D., Dixon, W. G., Bechtold, D. A., Gill, S., Little, M. A., Luik, A., Loudon, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms10889 · Cited by 312 · see citing works
Molecular insights into human daily behavior
Brown, S. A., Kunz, D., Dumas, A., Westermark, P. O., Vanselow, K., Tilmann-Wahnschaffe, A., Herzel, H., & Kramer, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707772105 · Cited by 270 · see citing works
Chao, L. H., Stratton, M. M., Lee, I., Rosenberg, O. S., Levitz, J., Mandell, D. J., Kortemme, T., Groves, J. T., Schulman, H., & Kuriyan, J. (2011) · Cell · doi:10.1016/j.cell.2011.07.038 · Cited by 253 · see citing works
Another place, another timer: marine species and the rhythms of life
Tessmar‐Raible, K., Raible, F., & Arboleda, E. (2011) · BioEssays · doi:10.1002/bies.201000096 · Cited by 208 · see citing works
Self-citationSandrelli, F., Tauber, E., Pegoraro, M., Mazzotta, G., Cisotto, P., Landskron, J., Stanewsky, R., Piccin, A., Rosato, E., Zordan, M., et al. (2007) · Science · doi:10.1126/science.1138426 · Cited by 205 · see citing works
Preparation and purification of DNA from insects for AFLP analysis
Reineke, A., Karlovský, P., & Zebitz, C. P. W. (1998) · Insect Molecular Biology · doi:10.1046/j.1365-2583.1998.71048.x · Cited by 189 · see citing works
Compact genome of the Antarctic midge is likely an adaptation to an extreme environment
Kelley, J. L., Peyton, J. T., Fiston-Lavier, A.-S., Teets, N. M., Yee, M.-C., Johnston, J. S., Bustamante, C. D., Lee, R. E., & Denlinger, D. L. (2014) · Nature Communications · doi:10.1038/ncomms5611 · Cited by 171 · see citing works
Hamblen, M. J., Wheeler, D. A., Rutila, J. E., Rosbash, M., & Hall, J. C. (1992) · Journal of Insect Behavior · doi:10.1007/bf01058189 · Cited by 167 · see citing works
Nawathean, P., & Rosbash, M. (2004) · Molecular Cell · doi:10.1016/s1097-2765(03)00503-3 · Cited by 161 · see citing works
Logan, R. W., Edgar, N. M., Gillman, A. G., Hoffman, D., Zhu, X., & McClung, C. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.011 · Cited by 154 · see citing works
Circadian and circalunar clock interactions in a marine annelid
Zantke, J., Ishikawa-Fujiwara, T., Arboleda, E., Lohs, C., Schipany, K., Hallay, N., Straw, A. D., Todo, T., & Tessmar-Raible, K. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.031 · Cited by 148 · see citing works
Self-citationEmerging role of CaMKII in neuropsychiatric disease
Robison, A. J. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.07.001 · Cited by 142 · see citing works
The Drosophila dCREB2 Gene Affects the Circadian Clock
Belvin, M. P., Zhou, H., & Yin, J. C. P. (1999) · Neuron · doi:10.1016/s0896-6273(00)80736-9 · Cited by 141 · see citing works
Gusev, O., Suetsugu, Y., Cornette, R., Kawashima, T., Logacheva, M. D., Kondrashov, A. S., Penin, A. A., Hatanaka, R., Kikuta, S., Shimura, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms5784 · Cited by 136 · see citing works
Intracellular Ca2+Regulates Free-Running Circadian Clock OscillationIn Vivo
Harrisingh, M. C., Wu, Y., Lnenicka, G. A., & Nitabach, M. N. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3680-07.2007 · Cited by 132 · see citing works
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation
Chao, L. H., Pellicena, P., Deindl, S., Barclay, L. A., Schulman, H., & Kuriyan, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1751 · Cited by 119 · see citing works
Coactivation of the CLOCK–BMAL1 complex by CBP mediates resetting of the circadian clock
Lee, Y., Lee, J., Kwon, I., Nakajima, Y., Ohmiya, Y., Son, G. H., Lee, K. H., & Kim, K. (2010) · Journal of Cell Science · doi:10.1242/jcs.070300 · Cited by 118 · see citing works
Neumann, D. (1966) · Zeitschrift f�r Vergleichende Physiologie · doi:10.1007/bf00343045 · Cited by 116 · see citing works
Evolution and Phylogeny of the Diptera: A Molecular Phylogenetic Analysis Using 28S rDNA Sequences
Friedrich, M., & Tautz, D. (1997) · Systematic Biology · doi:10.1093/sysbio/46.4.674 · Cited by 114 · see citing works
Wu, X., & McMurray, C. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006727200 · Cited by 102 · see citing works
LDx: Estimation of Linkage Disequilibrium from High-Throughput Pooled Resequencing Data
Feder, A. F., Petrov, D. A., & Bergland, A. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048588 · Cited by 98 · see citing works
Drosophila timeless2 Is Required for Chromosome Stability and Circadian Photoreception
Benna, C., Bonaccorsi, S., Wülbeck, C., Helfrich‐Förster, C., Gatti, M., Kyriacou, C. P., Costa, R., & Sandrelli, F. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.048 · Cited by 82 · see citing works
Genetic basis of human circadian rhythm disorders
Jones, C. R., Huang, A. L., Ptáček, L. J., & Fu, Y. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.07.012 · Cited by 79 · see citing works
Rhythmic U2af26 Alternative Splicing Controls PERIOD1 Stability and the Circadian Clock in Mice
Preußner, M., Wilhelmi, I., Schultz, A.-S., Finkernagel, F., Michel, M., Möröy, T., & Heyd, F. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.015 · Cited by 74 · see citing works
Self-citationKon, N., Yoshikawa, T., Honma, S., Yamagata, Y., Yoshitane, H., Shimizu, K., Sugiyama, Y., Hara, C., Kameshita, I., Honma, K., et al. (2014) · Genes & Development · doi:10.1101/gad.237511.114 · Cited by 73 · see citing works
Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE‐dependent transcription
Weber, F., Hung, H., Maurer, C., & Kay, S. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03865.x · Cited by 60 · see citing works
Signaling Mechanisms in Cortical Axon Growth, Guidance, and Branching
Kalil, K., Li, L., & Hutchins, B. I. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00062 · Cited by 56 · see citing works
Functional Role of CREB-Binding Protein in the Circadian Clock System of Drosophila melanogaster
Lim, C., Lee, J., Choi, C., Kim, J., Doh, E., & Choe, J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02155-06 · Cited by 52 · see citing works
Kaiser, T. S., Neumann, D., & Heckel, D. G. (2011) · BMC Genetics · doi:10.1186/1471-2156-12-49 · Cited by 47 · see citing works
Self-citationKaiser, T. S., & Heckel, D. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032092 · Cited by 37 · see citing works
Self-citationGenetic adaptation in emergence time ofClunio populations to different tidal conditions
Neumann, D. (1967) · Helgoländer Wissenschaftliche Meeresuntersuchungen · doi:10.1007/bf01618620 · Cited by 36 · see citing works
Kaiser, T. S., NEUMANN, D., Heckel, D. G., & Berendonk, T. U. (2010) · Molecular Ecology · doi:10.1111/j.1365-294x.2010.04706.x · Cited by 34 · see citing works
Self-citationSNP2GO: Functional Analysis of Genome-Wide Association Studies
Szkiba, D., Kapun, M., von Haeseler, A., & Gallach, M. (2014) · Genetics · doi:10.1534/genetics.113.160341 · Cited by 32 · see citing works
Self-citationChironomid Midges (Diptera, Chironomidae) Show Extremely Small Genome Sizes
Cornette, R., Gusev, O., Nakahara, Y., Shimura, S., Kikawada, T., & Okuda, T. (2015) · ZOOLOGICAL SCIENCE · doi:10.2108/zs140166 · Cited by 31 · see citing works
Signaling to the microtubule cytoskeleton: An unconventional role for C a MKII
McVicker, D. P., Millette, M. M., & Dent, E. W. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22227 · Cited by 27 · see citing works
Guptaroy, B., Marwaha, N., Pla, M., Wang, Z., Nelson, H. B., Beckingham, K., & Griffith, L. C. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00115-7 · Cited by 26 · see citing works
Structural plasticity of the circadian timing system. An overview from flies to mammals
Bosler, O., Girardet, C., Franc, J., Becquet, D., & François‐Bellan, A. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.02.001 · Cited by 22 · see citing works
Temperature compensation of circasemilunar timing in the intertidal insectClunio
Neumann, D. (1988) · Journal of Comparative Physiology A · doi:10.1007/bf00603851 · Cited by 21 · see citing works
Promoter Analysis for Daily Expression of Drosophila timeless Gene
Okada, T., Sakai, T., Murata, T., Kako, K., Sakamoto, K., Ohtomi, M., Katsura, T., & Ishida, N. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4793 · Cited by 20 · see citing works
Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say?
Zordan, M. A., & Sandrelli, F. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00080 · Cited by 17 · see citing works
Scaffolder - software for manual genome scaffolding
Barton, M. D., & Barton, H. A. (2012) · Source Code for Biology and Medicine · doi:10.1186/1751-0473-7-4 · Cited by 14 · see citing works
Molecular Evolution of a Pervasive Natural Amino-Acid Substitution in Drosophila cryptochrome
Pegoraro, M., Noreen, S., Bhavnani, S., Tsolou, A., Schmid, R., Kyriacou, C. P., & Tauber, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086483 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 74 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [66]Crawley, M. J. The R Book. (John Wiley & Sons Ltd., 2007)
- [76]Heimbach, F. Semilunare und diurnale Schlüpfrhythmen südenglischer und norwegischer Clunio-Populationen (Diptera, Chironomidae) PhD thesis, Universität Köln (1976)
Cited by
Sorted by citations
Fuentes‐Pardo, A. P., & Ruzzante, D. E. (2017) · Molecular Ecology · doi:10.1111/mec.14264 · Cited by 396 · see citing works
The origins and evolution of sleep
Keene, A. C., & Duboué, E. R. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.159533 · Cited by 224 · see citing works
Two sides of a coin: ecological and chronobiological perspectives of timing in the wild
Helm, B., Visser, M. E., Schwartz, W. J., Kronfeld‐Schor, N., Gerkema, M. P., Piersma, T., & Bloch, G. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0246 · Cited by 208 · see citing works
Model and Non-model Insects in Chronobiology
Beer, K., & Helfrich‐Förster, C. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.601676 · Cited by 125 · see citing works
An Overview of Monthly Rhythms and Clocks
Raible, F., Takekata, H., & Tessmar-Raible, K. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00189 · Cited by 121 · see citing works
Self-citationThe Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks
Andreatta, G., & Tessmar-Raible, K. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.03.009 · Cited by 111 · see citing works
Self-citationLiu, J.-L., Xu, X., Rixiati, Y., Wang, C., Ni, H., Chen, W., Gong, H.-M., Zhang, Z., Shi, L., Shen, T., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.019 · Cited by 109 · see citing works
Petrou, E. L., Fuentes‐Pardo, A. P., Rogers, L. A., Orobko, M., Tarpey, C. M., Jiménez-Hidalgo, I., Moss, M. L., Yang, D. Y., Pitcher, T. J., Sandell, T., et al. (2021) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2020.2398 · Cited by 79 · see citing works
Rhythms and Clocks in Marine Organisms
Häfker, N. S., Andreatta, G., Manzotti, A., Falciatore, A., Raible, F., & Tessmar‐Raible, K. (2022) · Annual Review of Marine Science · doi:10.1146/annurev-marine-030422-113038 · Cited by 73 · see citing works
Self-citationSchenk, S., Bannister, S. C., Sedlazeck, F. J., Anrather, D., Minh, B. Q., Bileck, A., Hartl, M., von Haeseler, A., Gerner, C., Raible, F., et al. (2019) · eLife · doi:10.7554/elife.41556 · Cited by 59 · see citing works
Self-citationCaMKII Measures the Passage of Time to Coordinate Behavior and Motivational State
Thornquist, S. C., Langer, K., Zhang, S. X., Rogulja, D., & Crickmore, M. A. (2019) · Neuron · doi:10.1016/j.neuron.2019.10.018 · Cited by 56 · see citing works
Rhythms of behavior: are the times changin’?
Häfker, N. S., & Tessmar‐Raible, K. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.10.005 · Cited by 58 · see citing works
Self-citationDillon, M. E., & Lozier, J. D. (2019) · Current Opinion in Insect Science · doi:10.1016/j.cois.2019.09.003 · Cited by 55 · see citing works
Genetic basis of allochronic differentiation in the fall armyworm
Hänniger, S., Dumas, P., Schöfl, G., Gebauer-Jung, S., Vogel, H., Unbehend, M., Heckel, D. G., & Groot, A. T. (2017) · BMC Evolutionary Biology · doi:10.1186/s12862-017-0911-5 · Cited by 54 · see citing works
Self-citationMarine artificial light at night: An empirical and technical guide
Tidau, S., Smyth, T., McKee, D., Wiedenmann, J., D’Angelo, C., Wilcockson, D. C., Ellison, A., Grimmer, A. J., Jenkins, S. R., Widdicombe, S., et al. (2021) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.13653 · Cited by 48 · see citing works
Periodicity, repression, and the molecular architecture of the mammalian circadian clock
Rosensweig, C., & Green, C. B. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14254 · Cited by 46 · see citing works
Marine biorhythms: bridging chronobiology and ecology
Bulla, M., Oudman, T., Bijleveld, A. I., Piersma, T., & Kyriacou, C. P. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0253 · Cited by 45 · see citing works
Hunt, L. C., Jiao, J., Wang, Y., Finkelstein, D., Rao, D., Curley, M., Robles‐Murguia, M., Shirinifard, A., Pagala, V., Peng, J., et al. (2019) · Genome Research · doi:10.1101/gr.246884.118 · Cited by 42 · see citing works
Transcriptome dynamics over a lunar month in a broadcast spawning acroporid coral
Oldach, M. J., Workentine, M., Matz, M. V., Fan, T., & Vize, P. D. (2017) · Molecular Ecology · doi:10.1111/mec.14043 · Cited by 39 · see citing works
Flies as models for circadian clock adaptation to environmental challenges
Helfrich‐Förster, C., Bertolini, E., & Menegazzi, P. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14180 · Cited by 40 · see citing works
Yoon, Y., Klomp, J. A., Martín-Martín, I., Criscione, F., Calvo, E., Ribeiro, J. M. C., & Schmidt‐Ott, U. (2019) · eLife · doi:10.7554/elife.46711 · Cited by 37 · see citing works
Poehn, B., Krishnan, S., Zurl, M., Ćorić, A., Rokvić, D., Häfker, N. S., Jaenicke, E., Arboleda, E., Orel, L., Raible, F., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32562-z · Cited by 40 · see citing works
Self-citationSeasonal timing on a cyclical Earth: Towards a theoretical framework for the evolution of phenology
Park, J. S., & Post, E. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001952 · Cited by 35 · see citing works
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII
Konstantinidis, K., Bezzerides, V. J., Lai, L., Isbell, H. M., Wei, A., Wu, Y., Viswanathan, M. C., Blum, I. D., Granger, J. M., Heims-Waldron, D. A., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133181 · Cited by 36 · see citing works
Benchmarking the performance of Pool‐seq SNP callers using simulated and real sequencing data
Guirao‐Rico, S., & González, J. (2021) · Molecular Ecology Resources · doi:10.1111/1755-0998.13343 · Cited by 35 · see citing works
Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
Barone, I., Gilette, N. M., Hawks-Mayer, H., Handy, J., Zhang, K. J., Chifamba, F. F., Mostafa, E., Johnson‐Venkatesh, E., Sun, Y., Gibson, J. M., et al. (2023) · Science Advances · doi:10.1126/sciadv.adj1010 · Cited by 33 · see citing works
Circalunar clocks—Old experiments for a new era
Kaiser, T. S., & Neumann, J. (2021) · BioEssays · doi:10.1002/bies.202100074 · Cited by 33 · see citing works
Self-citationNon-Pleiotropic Coupling of Daily and Seasonal Temporal Isolation in the European Corn Borer
Levy, R., Kozak, G. M., & Dopman, E. B. (2018) · Genes · doi:10.3390/genes9040180 · Cited by 31 · see citing works
Schmidt, H., Waldvogel, A., Hellmann, S. L., Feldmeyer, B., Hankeln, T., & Pfenninger, M. (2020) · G3 Genes Genomes Genetics · doi:10.1534/g3.119.400710 · Cited by 31 · see citing works
Kon, N., Wang, H.-T., Kato, Y. S., Uemoto, K., Kawamoto, N., Kawasaki, K., Enoki, R., Kurosawa, G., Nakane, T., Sugiyama, Y., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe8132 · Cited by 28 · see citing works
Low recombination rates in sexual species and sex–asex transitions
Haag, C. R., Theodosiou, L., Jabbour‐Zahab, R., & Lenormand, T. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0461 · Cited by 29 · see citing works
Wiegmann, B. M., & Richards, S. (2018) · Current Opinion in Insect Science · doi:10.1016/j.cois.2018.01.007 · Cited by 29 · see citing works
Analysis of the circadian transcriptome of the Antarctic krill Euphausia superba
Biscontin, A., Martini, P. G. V., Costa, R., Kramer, A., Meyer, B., Kawaguchi, S., Teschke, M., & Pittà, C. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-50282-1 · Cited by 28 · see citing works
The brown clock: circadian rhythms in stramenopiles
Farré, E. M. (2020) · Physiologia Plantarum · doi:10.1111/ppl.13104 · Cited by 27 · see citing works
Timing strains of the marine insect Clunio marinus diverged and persist with gene flow
Kaiser, T. S., von Haeseler, A., Tessmar‐Raible, K., & Heckel, D. G. (2021) · Molecular Ecology · doi:10.1111/mec.15791 · Cited by 27 · see citing works
Self-citationSun, X., Liu, W., Li, R., Zhao, C.-L., Pan, L., & Yan, C.-C. (2021) · Molecular Ecology Resources · doi:10.1111/1755-0998.13377 · Cited by 23 · see citing works
Belgica antarctica (Diptera: Chironomidae): A natural model organism for extreme environments
Kozeretska, I. A., Serga, S. V., Kovalenko, P. A., Gorobchyshyn, V. A., & Convey, P. (2021) · Insect Science · doi:10.1111/1744-7917.12925 · Cited by 26 · see citing works
Evolution of simple multicellular life cycles in dynamic environments
Pichugin, Y., Park, H. J., & Traulsen, A. (2019) · Journal of The Royal Society Interface · doi:10.1098/rsif.2019.0054 · Cited by 26 · see citing works
Wuitchik, D. M., Wang, D., Pells, T. J., Karimi, K., Ward, S., & Vize, P. D. (2019) · Molecular Ecology · doi:10.1111/mec.15173 · Cited by 24 · see citing works
Finch, G., Nandyal, S., Perretta, C., Davies, B., Rosendale, A. J., Holmes, C. J., Gantz, J. D., Spacht, D. E., Bailey, S. T., Chen, X., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76139-6 · Cited by 24 · see citing works
Polygenic adaptation from standing genetic variation allows rapid ecotype formation
Fuhrmann, N., Prakash, C., & Kaiser, T. S. (2023) · eLife · doi:10.7554/elife.82824 · Cited by 26 · see citing works
Self-citationDaytime variation in SARS-CoV-2 infection and cytokine production
Diallo, A. B., Gay, L., Coiffard, B., Léone, M., Mezouar, S., & Mège, J. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105067 · Cited by 24 · see citing works
Prostaglandin E2 synchronizes lunar-regulated beach spawning in grass puffers
Chen, J., Katada, Y., Okimura, K., Yamaguchi, T., Guh, Y.-J., Nakayama, T., Maruyama, M., Furukawa, Y., Nakane, Y., Yamamoto, N., et al. (2022) · Current Biology · doi:10.1016/j.cub.2022.09.062 · Cited by 23 · see citing works
Characterization of cis-acting elements that control oscillating alternative splicing
Goldammer, G., Neumann, A., Strauch, M., Müller-McNicoll, M., Heyd, F., & Preußner, M. (2018) · RNA Biology · doi:10.1080/15476286.2018.1502587 · Cited by 17 · see citing works
Self-citationLiu, W., Sun, X., Sun, W., Zhou, A., Li, R., Wang, B., Li, X., & Yan, C. (2021) · Aquatic Toxicology · doi:10.1016/j.aquatox.2021.105940 · Cited by 17 · see citing works
Chironomid midges (Diptera) provide insights into genome evolution in extreme environments
Shaikhutdinov, N., & Gusev, O. (2022) · Current Opinion in Insect Science · doi:10.1016/j.cois.2021.12.009 · Cited by 17 · see citing works
Circadian and circatidal clocks control the mechanism of semilunar foraging behaviour
Cheeseman, J. F., Fewster, R. M., & Walker, M. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-03245-3 · Cited by 17 · see citing works
Molecular circadian rhythms are robust in marine annelids lacking rhythmic behavior
Häfker, N. S., Holcik, L., Mat, A. M., Ćorić, A., Vadiwala, K., Beets, I., Stockinger, A. W., Atria, C. E., Hammer, S., Revilla‐i‐Domingo, R., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002572 · Cited by 13 · see citing works
Self-citationDifferential Impacts of the Head on Platynereis dumerilii Peripheral Circadian Rhythms
Arboleda, E., Zurl, M., Waldherr, M., & Tessmar‐Raible, K. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00900 · Cited by 14 · see citing works
Self-citationPhotoperiod is an important seasonal selection factor in Chironomus riparius (Diptera: Chironomidae)
Doria, H. B., Caliendo, C., Gerber, S., & Pfenninger, M. (2021) · Biological Journal of the Linnean Society · doi:10.1093/biolinnean/blab147 · Cited by 13 · see citing works
Maritime midge radiations in the Pacific Ocean (Diptera: Chironomidae)
Tang, H., Cheng, Q., Krosch, M. N., & Cranston, P. S. (2022) · Systematic Entomology · doi:10.1111/syen.12565 · Cited by 12 · see citing works
Preußner, M., & Heyd, F. (2018) · BioEssays · doi:10.1002/bies.201700216 · Cited by 12 · see citing works
Self-citationArthropod Genome Sequencing and Assembly Strategies
Richards, S. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8775-7_1 · Cited by 12 · see citing works
Artificial light at night reduces emergence and attracts flying adults of aquatic Diptera
Manfrin, A., Hölker, F., Teurlincx, S., BARANOV, V. A., van Grunsven, R. H. A., Bundschuh, M., & Monaghan, M. T. (2025) · Aquatic Sciences · doi:10.1007/s00027-025-01161-7 · Cited by 11 · see citing works
Chapter 32: Chronobiology of blood-feeding arthropods: influences on their role as disease vectors
Benoit, J. B., & Vinauger, C. (2022) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-932-9_32 · Cited by 11 · see citing works
Developmental and sexual divergence in the olfactory system of the marine insect Clunio marinus
Mißbach, C., Vogel, H., Hansson, B. S., Große‐Wilde, E., Vilcinskas, A., & Kaiser, T. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-59063-7 · Cited by 10 · see citing works
Self-citationConformational spread drives the evolution of the calcium–calmodulin protein kinase II
Khan, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-12090-y · Cited by 8 · see citing works
Briševac, D., Peralta, C. M., & Kaiser, T. S. (2023) · eLife · doi:10.7554/elife.82825 · Cited by 7 · see citing works
Self-citationZhou, D., Chen, Y., Liu, P., Zhu, K., Holder-Haynes, J. G., Lloyd, S. J.-A., La, C. M., Astapova, I. I., Choa, S., Xiong, Y., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.07.010 · Cited by 7 · see citing works
Kalemkeridou, M., Nanas, I., Moutou, K. A., Amiridis, G. S., Τσιπουρλιάνος, Α., Dovolou, E., Mamuris, Z., & Giannoulis, T. (2022) · Reproduction in Domestic Animals · doi:10.1111/rda.14274 · Cited by 7 · see citing works
Poon, L., Jenks, I. T., & Crampton, W. G. R. (2024) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.14299 · Cited by 7 · see citing works
Fuhrmann, N., & Kaiser, T. S. (2020) · Genome · doi:10.1139/gen-2019-0191 · Cited by 7 · see citing works
Self-citationKwiatkowski, E. R., Rosenthal, J. J. C., & Emery, P. (2024) · Current Biology · doi:10.1016/j.cub.2024.09.067 · Cited by 6 · see citing works
Michailova, P., Lencioni, V., Nenov, M., & Nikolov, S. (2021) · Zootaxa · doi:10.11646/zootaxa.4927.1.1 · Cited by 6 · see citing works
Kawasaki, Y., Nishimura, H., & Shiga, S. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.163253 · Cited by 6 · see citing works
The Report of Marine Life Genomic ResearchPreprint
Fan, G., Chen, J., Jin, T., Shi, C., Du, X., Zhang, H., Zhang, Y., Li, H., Luo, T. L., Yan, P., et al. (2018) · Preprints.org · doi:10.20944/preprints201812.0156.v1 · Cited by 5 · see citing works
Cross-ecosystem effects of light pollution and invasive signal crayfish on riparian spiders
Manfrin, A., Schirmel, J., Arias, M., Entling, M. H., Hoffmann, J., Huszarik, M., Kolb, S., Schrimpf, A. M., Schmidt, T., Bundschuh, M., et al. (2025) · Global Ecology and Conservation · doi:10.1016/j.gecco.2025.e03577 · Cited by 5 · see citing works
Ekrem, R. K., Jacobsen, A., Kokko, H., & Kaiser, T. S. (2025) · Ecology Letters · doi:10.1111/ele.70139 · Cited by 5 · see citing works
Self-citationPhylogenomics of an early-branching clade of Orthocladiinae (Diptera: Chironomidae)
Xu, H., Zhang, Z.-C., Zhang, D., BARANOV, V. A., Li, C., & Lin, X. (2025) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2025.108477 · Cited by 4 · see citing works
Bouinier, T., Smadi, C., & Llaurens, V. (2025) · Oikos · doi:10.1002/oik.11567 · Cited by 4 · see citing works
Nicolas, L. A., Berdan, E. L., Wellenreuther, M., Colinet, H., Clouard, A., Wit, P. D., Glémin, S., & Mérot, C. (2025) · Heredity · doi:10.1038/s41437-025-00808-3 · Cited by 4 · see citing works
Clocks at sea: the genome-editing tide is rising
Kwiatkowski, E. R., Rosenthal, J. J. C., & Emery, P. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.01.006 · Cited by 4 · see citing works
Ekrem, R. K., de Vries, C., Kaiser, T. S., & Kokko, H. (2025) · Journal of Animal Ecology · doi:10.1111/1365-2656.70094 · Cited by 4 · see citing works
Self-citationBranch point strength controls species-specificCAMK2Balternative splicing and regulates LTP
Franz, A., Weber, A. I., Preußner, M., Dimos, N., Stumpf, A., Ji, Y., Velasquez, L. M., Voigt, A., Schulz, F., Neumann, A., et al. (2022) · Life Science Alliance · doi:10.26508/lsa.202201826 · Cited by 4 · see citing works
Self-citationLiu, W., Zhou, A., Nie, J., Shao, Z., Nie, Z., Zhang, Y., Liu, C., Yan, C., Gao, S., & Wang, Y. (2025) · Biology · doi:10.3390/biology14091111 · Cited by 3 · see citing works
Liu, W., Zhao, K., Zhou, A., Wang, X., Ge, X., Qiao, H., Sun, X., Yan, C., & Wang, Y. (2024) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2024.101248 · Cited by 3 · see citing works
Liu, W., Zhou, A., Shao, Z., Nie, J., Ge, X., Yan, C., Gao, S., & Wang, Y. (2025) · BMC Genomics · doi:10.1186/s12864-025-11847-9 · Cited by 3 · see citing works
Assessment of Circalunar (~Monthly) Rhythms
Poehn, B., & Tessmar‐Raible, K. (2022) · Neuromethods · doi:10.1007/978-1-0716-2577-4_10 · Cited by 3 · see citing works
Self-citationLunar and Tidal Rhythms and Clocks
Neumann, J., & Kaiser, T. S. (2023) · Entomology monographs · doi:10.1007/978-981-99-0726-7_10 · Cited by 3 · see citing works
Self-citationKappeler, P. M. (2021) · Springer eBooks · doi:10.1007/978-3-030-82879-0_5 · Cited by 3 · see citing works
Modeling the role of gravitation in metabolic processes
Thorne, S. (2021) · Communicative & Integrative Biology · doi:10.1080/19420889.2021.1914913 · Cited by 3 · see citing works
Neumann, J., Rajendra, D., & Kaiser, T. S. (2024) · Journal of Biological Rhythms · doi:10.1177/07487304241249516 · Cited by 2 · see citing works
Self-citationCommon Ground between Biological Rhythms and Forensics
Janjić, K., Reisinger, C., & Kanz, F. (2022) · Biology · doi:10.3390/biology11071071 · Cited by 2 · see citing works
Genetic analysis of a phenotypic loss in the mechanosensory entrainment of a circalunar clock
Briševac, D., Prakash, C., & Kaiser, T. S. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010763 · Cited by 2 · see citing works
Self-citationLunar cycle-mediated behaviours in animals, including humans
Mandal, F. B. (2023) · Israel Journal of Ecology and Evolution · doi:10.1163/22244662-bja10060 · Cited by 3 · see citing works
Chronobiology as compensation: can biological rhythms compensate for sexual signals?
Westwood, M. L., Broder, E. D., Welsh, G. T., & Tinghitella, R. M. (2025) · Frontiers in Ethology · doi:10.3389/fetho.2024.1473358 · Cited by 2 · see citing works
Martin, S. L. F., Torre, R. L., Danneels, B., Tooming‐Klunderud, A., Skage, M., Kollias, S., Tørresen, O. K., Falahati‐Anbaran, M., Stur, E., Jakobsen, K. S., et al. (2025) · GigaScience · doi:10.1093/gigascience/giaf160 · Cited by 2 · see citing works
Ando, H. (2018) · Hikaku seiri seikagaku(Comparative Physiology and Biochemistry) · doi:10.3330/hikakuseiriseika.35.45 · Cited by 2 · see citing works
On the fitness of informative cues in complex environments
Mafessoni, F., Lachmann, M., & Gokhale, C. S. (2021) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2021.110819 · Cited by 2 · see citing works
Michailova, P., Kovalenko, P. A., Serga, S. V., Parnikoza, I., Kozeretska, I. A., & Convey, P. (2023) · Antarctic Science · doi:10.1017/s0954102023000202 · Cited by 1 · see citing works
Seasonal Dynamics of Non-Biting Midges (Diptera: Chironomidae) and Relevant Environmental Factors
Lei, T., Gu, J., Zhao, M., Chen, Y., Song, C., & Qi, X. (2024) · Insects · doi:10.3390/insects15120921 · Cited by 1 · see citing works
Insect circadian plasticity as a proposed target for the expression of parasite extended phenotypes
Dopp, J., & de Bekker, C. (2025) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00046-0 · Cited by 1 · see citing works
How competition can drive allochronic divergence: A case study in the Marine Midge, Clunio marinus
Jacobsen, A. G. G., Kaiser, T. S., & Gokhale, C. S. (2026) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1014235 · Cited by 1 · see citing works
Self-citationFrontiers in Chronobiology: Endogenous Clocks at the Core of Signaling Pathways in Physiology
Costa, R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.684745 · Cited by 2 · see citing works
Finch, G., Nandyal, S., Perrieta, C., Davies, B., Rosendale, A. J., Holmes, C. J., Gantz, J. D., Spacht, D. E., Bailey, S. T., Chen, X., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/796797 · Cited by 1 · see citing works
Biological Clocks and Circadian Rhythms
Kon, N., & Fukada, Y. (2019) · TRENDS IN THE SCIENCES · doi:10.5363/tits.24.8_8 · Cited by 1 · see citing works
Phenological evolution on a cyclical Earth: towards first principles and null expectationsPreprint
Park, J. S., & Post, E. (2022) · doi:10.22541/au.166939385.55232019/v1 · Cited by 1 · see citing works
Conformational Spread Drives the Evolution of the Calcium-calmodulin Protein Kinase IIPreprint
Khan, S. (2021) · Research Square · doi:10.21203/rs.3.rs-506808/v1
Kita, A., Elsayed, A. K., & Tokuda, M. (2022) · Biodiversity Data Journal · doi:10.3897/bdj.10.e79184
- Authors
- Kaiser, T. S., Poehn, B., Szkiba, D., Preussner, M., Sedlazeck, F. J., Zrim, A., Neumann, T., Nguyen, L.-T., Betancourt, A. J., Hummel, T., Vogel, H., Dorner, S., Heyd, F., von Haeseler, A., & Tessmar-Raible, K.
- Affiliations
- University of Vienna (AT)
- Freie Universität Berlin (DE)
- University of Veterinary Medicine Vienna (AT)
- Max Planck Institute for Chemical Ecology (DE)
- Corresponding author
- Kaiser, Tobias S.
- ORCID
- Venue
- Nature
- Published
- 2016-11-21
- Volume
- 540
- Issue
- 7631
- Pages
- 69-73
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5133387
- OpenAlex
- W2555773426
- Cited by
- 109
- References
- 74
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 9 · 2023: 7 · 2022: 19 · 2021: 16 · 2020: 11 · 2019: 12 · 2018: 11 · 2017: 9
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Nature (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
- Funders
- Deutsche Forschungsgemeinschaft (FP7/2007–2013, HE5398/4)
- Austrian Science Fund (#AY0041321)
- Universität Wien (I059-N)
- FP7 Ideas: European Research Council (337011)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- Clunio marinus, circadian clock, chronotype, alternative splicing, calcium/calmodulin-dependent kinase II, quantitative trait loci, natural genetic variation, Drosophila melanogaster
- MeSH terms
- Acclimatization, Animals, Chironomidae, Circadian Rhythm, Drosophila melanogaster, Male, Phenotype, Reproduction, Species Specificity, Time Factors, Transcription, Genetic, Genetic Variation, Moon, Alternative Splicing, Genomics, Quantitative Trait Loci, Genome, Insect, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Tidal Waves, Genetic Association Studies, CLOCK Proteins, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
