Restriction of an Extinct Retrovirus by the Human TRIM5α Antiviral Protein

The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys

Stremlau, M. H., Owens, C. M., Perron, M. J., Kießling, M. K., Autissier, P., & Sodroski, J. (2004) · Nature · doi:10.1038/nature02343 · Cited by 1,810

Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1

Keele, B. F., Heuverswyn, F. V., Li, Y., Bailes, E., Takehisa, J., Santiago, M. L., Bibollet‐Ruche, F., Chen, Y., Wain, L. V., Liégeois, F., et al. (2006) · Science · doi:10.1126/science.1126531 · Cited by 955

Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor

Stremlau, M. H., Perron, M. J., Lee, M. N., Li, Y., Song, B., Javanbakht, H., Diaz‐Griffero, F., Anderson, D. J., Sundquist, W. I., & Sodroski, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509996103 · Cited by 736

Positive selection of primate TRIM5 α identifies a critical species-specific retroviral restriction domain

Sawyer, S. L., Wu, L. I., Emerman, M., & Malik, H. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409853102 · Cited by 688

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G

Sawyer, S. L., Emerman, M., & Malik, H. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020275 · Cited by 485

A Single Amino Acid Change in the SPRY Domain of Human Trim5α Leads to HIV-1 Restriction

Yap, M. W., Nisole, S., & Stoye, J. P. (2005) · Current Biology · doi:10.1016/j.cub.2004.12.042 · Cited by 408

SIV infection in wild gorillas

Heuverswyn, F. V., Li, Y., Neel, C., Bailes, E., Keele, B. F., Liu, W., Loul, S., Butel, C., Liégeois, F., Bienvenue, Y., et al. (2006) · Nature · doi:10.1038/444164a · Cited by 408

Species-Specific Variation in the B30.2(SPRY) Domain of TRIM5α Determines the Potency of Human Immunodeficiency Virus Restriction

Stremlau, M. H., Perron, M. J., Welikala, S., & Sodroski, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.3139-3145.2005 · Cited by 372

Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5α

Hatziioannou, T., Pérez-Caballero, D., Yang, A., Cowan, S., & Bieniasz, P. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402361101 · Cited by 371

Reconstitution of an Infectious Human Endogenous Retrovirus

Lee, Y. N., & Bieniasz, P. D. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030010 · Cited by 311

Evolution of the Human Immune System

Danilova, N. (2008) · Wiley eBooks · doi:10.1002/9780470015902.a0020781 · Cited by 13

Apparent effect of rabbit endogenous lentivirus type K acquisition on retrovirus restriction by lagomorph Trim5αs

Yap, M. W., & Stoye, J. P. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0498 · Cited by 14

Approaches to serious methicillin-resistant Staphylococcus aureus infections with decreased susceptibility to vancomycin: clinical significance and options for management

Lewis, J. S., & Ellis, M. W. (2008) · Current Opinion in Internal Medicine · doi:10.1097/qco.0b013e3282f1beb8 · Cited by 13

Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses

Yap, M. W., Young, G. R., Varnaitė, R., Morand, S., & Stoye, J. P. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008471 · Cited by 10

Targeting Protein–Protein Interactions for HIV Therapeutics

Rice, A. P., & Sutton, R. E. (2007) · Future HIV Therapy · doi:10.2217/17469600.1.4.369 · Cited by 10

Have We Been Barking up the Wrong Ancestral Tree? Australopithecines Are Probably Not Our Ancestors

Vaneechoutte, M., Mansfield, F., Munro, S., & Verhaegen, M. (2024) · Nature anthropology · doi:10.35534/natanthropol.2023.10007 · Cited by 8

Effective T helper cell responses against retroviruses: are all clonotypes equal?

Thorborn, G., Young, G. R., & Kassiotis, G. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.2ri0613-347r · Cited by 9

Targeting TRIM5α in HIV Cure Strategies for the CRISPR-Cas9 Era

Weatherley, D. A. V., Boswell, M. T., & Rowland‐Jones, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01616 · Cited by 11

Evolution of the Human Immune System

Danilova, N. (2013) · Wiley eBooks · doi:10.1002/9780470015902.a0020781.pub2 · Cited by 9

Why Old World Monkeys Are Resistant to HIV-1

Stremlau, M. H. (2007) · Science · doi:10.1126/science.1152905 · Cited by 7

Experimental Molecular Archeology: Reconstruction of Ancestral Mutants and Evolutionary History of Proteins as a New Approach in Protein Engineering

Ogawa, T., & Shirai, T. (2013) · InTech eBooks · doi:10.5772/56255 · Cited by 4

Cellular and humoral factors of innate antiviral immunity

Moskalev, A. V., Gumilevsky, B. Y., Apchel, V. Y., & Vn, T. (2023) · Bulletin of the Russian Military Medical Academy · doi:10.17816/brmma108136 · Cited by 5

Simian Immunodeficiency Virus Infection and Mucosal Immunity

Xu, H., Wang, X., & Veazey, R. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00076-8 · Cited by 3

Features of the development of an adaptive antiviral immune response

Moskalev, A. V., Gumilevsky, B. Y., Apchel, A. V., & Vn, T. (2023) · Bulletin of the Russian Military Medical Academy · doi:10.17816/brmma109497 · Cited by 4

Current evidence indicates a Eurasian origin for the Last Common Ancestor of African apes and humans, and supports a new hypothesis suggesting that the Zanclean Megaflood (5.3 Ma) may have played a role in the ultimate divergence of Pan and Homo.

Mansfield, F., & Vaneechoutte, M. (2024) · Ideas in Ecology and Evolution · doi:10.24908/iee.2024.17.1.n · Cited by 2

Modern view on the role of pattern-recognition receptors and signaling pathways in the development of innate immunity in viral infections

Moskalev, A. V., Gumilevsky, B. Y., Apchel, V. Y., & Vn, T. (2022) · Bulletin of the Russian Military Medical Academy · doi:10.17816/brmma91018 · Cited by 3

Riboflavin transporter: evidence of a role as entry receptor for chimpanzee endogenous retrovirus

AbuEed, L., Miyake, A., Wanjala, N., Pramono, D., Abdillah, D. A., Imamura, M., Shimojima, M., Denner, J., Kawasaki, J., & Nishigaki, K. (2025) · Virus Evolution · doi:10.1093/ve/veaf031 · Cited by 1

Gammaretrovirus Infections in Humans in the Past, Present, and Future: Have We Defeated the Pathogen?

van der Kuyl, A. C. (2026) · Pathogens · doi:10.3390/pathogens15010104 · Cited by 1

From Simian to Human Immunodeficiency Viruses (SIV to HIV)

Tebit, D. M., & Arts, E. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-405191-1.00009-0 · Cited by 1

Etablierung eines Verfahrens zur Kombination der Elektronenmikroskopie (EM) mit der Spitzenverstärkten Raman-Spektroskopie (TERS) sowie Untersuchungen zum Infektionsprozess und der Ultrastruktur des Humanen Endogenen Retrovirus K (HERV-K)

Lausch, V. (2013) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-17346 · Cited by 1

Endogenous Retroviral Sequences; Their Evolutionary Contribution to the Human Genome

Mayer, J. M. (2013) · Wiley eBooks · doi:10.1002/9780470015902.a0020825.pub2 · Cited by 1

Retroviral insertions contributed to the divergence of human and chimpanzee brainsPreprint

Gerdes, P., Karlsson, O., Garza, R., Atacho, D. A. M., Hsieh, P., Prajapati, B., Muralidharan, C., Adami, A., Davis-Hansson, C., Johansson, E. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.12.693858 · Cited by 1

Host Factors that Restrict Retrovirus Replication

Stenglein, M. D., Schumacher, A. J., LaRue, R. S., & Harris, R. S. (2009) · Springer eBooks · doi:10.1007/b135974_15

Ancient disease resistance made us vulnerable to HIV

Hopkin, M. (2007) · Nature · doi:10.1038/news070618-15

Simian immunodeficiency virus (SIV) molecular epidemiology in non-human primates from West Africa

Locatelli, S. (2008) · edoc (University of Basel) · doi:10.5451/unibas-004524577

Dynamics of the Mammalian APOBEC3 Locus and the Relationship Between Mammalian APOBEC3 and Lentiviral Vif Proteins

LaRue, R. S. (2010) · University of Minnesota Digital Conservancy (University of Minnesota)

Cellular factors involved in HIV-1 replication

Rits, M. A. N. (2009) · UvA-DARE (University of Amsterdam)

COMPARATIVE AND FUNCTIONAL GENOMIC ANALYSIS OF

Thomas, J. W., & Choi, J. K. (2007)

Comparative and functional genomic analysis of human and chimpanzee retrotransposon sequences

Polavarapu, N. (2007) · SMARTech Repository (Georgia Institute of Technology)

Evolutionary Medicine I. An Overview and Applications to Cancer

Johnson, N. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800049-6.00310-3

ВИЧ/СПИД-пандемия — проблема, требующая переосмысления К 30-летию открытия вируса иммунодефицита человека

Supotnitsky, M. V. (2014) · ACTUAL INFECTOLOGY · doi:10.22141/2312-413x.3.04.2014.82459

Endogenous Retroviral Sequences; their Evolutionary Contribution to the Human Genome

Mayer, J. M. (2008) · Wiley eBooks · doi:10.1002/9780470015902.a0020825

HIV Genetics

Wolkowicz, R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-374984-0.00717-8

Protein signaling molecules affecting the development of innate immunity mechanisms

Moskalev, A. V., Gumilevsky, B. Y., Apchel, V. Y., & Vn, T. (2022) · Bulletin of the Russian Military Medical Academy · doi:10.17816/brmma100441 · Cited by 1

Genomic signatures of recent selection at HIV host susceptibility genes in a Central African human population

Zhao, K. X. (2012) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

Viral remnant in chimpanzees silences brain gene humans still use

Pusdekar, S. (2026) · The Transmitter · doi:10.53053/xsva4247

Etude de la restriction des cellules myeloïdes à l'infection lentivirale

Berger, G. (2011) · theses.fr (ABES) · doi:10.70675/5e6df030z045bz41b7z9b06z96a73dc15f6c

Interactions between primate lentiviral capsids and heterologous cellular host factors

Mamede, J. I. (2012) · theses.fr (ABES) · doi:10.70675/e3f4366bzb31fz4382z8f0cz19483f12bfe7

Identification et mesures de biomarqueurs infra-individuels chez le palmier dattier (Phoenix dactylifera) lors d’une contamination métallique : prédiction des voies métaboliques et description des mécanismes de détoxication des métaux impliqués

Chaâbene, Z. (2017) · theses.fr (ABES) · doi:10.70675/02647546zf4c7z4a91za170zc994f8e34eda

Virologie moléculaire d'un rétrovirus endogène humain fonctionnel

Lemaître, C. (2016) · theses.fr (ABES) · doi:10.70675/9964851dz8bdez4212zbebdz8e758164eb23

Inhibition de la transcription inverse du VIH-1 par la protéine Daxx

Maillet, S. (2020) · theses.fr (ABES) · doi:10.70675/54d97cdczd6ffz4611zae08zdf67cd500efd

Conflit moléculaire entre les protéines Vpr et Vpx des virus HIV/SIV et les facteurs HUSH et SAMHD1

Larrous, P. (2023) · theses.fr (ABES) · doi:10.70675/fc16267dzad68z4beczb28bz9a828aba2035

Histoire évolutive du plus ancien gène d’enveloppe rétrovirale endogène HEMO encore codant chez l’homme, exprimé dans le placenta et les tumeurs : acquisition récente d’une interaction avec une protéase transmembranaire chez les primates

Béguin, A. (2024) · theses.fr (ABES) · doi:10.70675/91026eb5zf996z44a3zad54z8065cd33958b

Retroviral insertions contributed to the divergence of human and chimpanzee brains

Gerdes, P., Karlsson, O., Garza, R., Atacho, D. A. M., Hsieh, P., Prajapati, B., Yoo, D., Muralidharan, C., Adami, A., Davis-Hansson, C., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeg5791 · Cited by 1

Antiretroviral Activity of Ancestral TRIM5α

Goldschmidt, V., Ciuffi, A., Ortiz, M., Brawand, D., Muñoz, M., Kaessmann, H., & Telenti, A. (2007) · Journal of Virology · doi:10.1128/jvi.01828-07 · Cited by 31

Retrovirus Restriction by TRIM5α Variants from Old World and New World Primates

Song, B., Javanbakht, H., Perron, M. J., Park, D. H., Stremlau, M. H., & Sodroski, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.7.3930-3937.2005 · Cited by 216

Isolation of an Active Lv1 Gene from Cattle Indicates that Tripartite Motif Protein-Mediated Innate Immunity to Retroviral Infection Is Widespread among Mammals

Ylinen, L. M. J., Keckesova, Z., Webb, B. L. J., Gifford, R. J., Smith, T. P. L., & Towers, G. J. (2006) · Journal of Virology · doi:10.1128/jvi.00516-06 · Cited by 60

Retroviral TRIMming

Minton, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1443

Adaptive evolution of primate TRIM5α, a gene restricting HIV-1 infection

Liu, H., Wang, Y., Liao, C., Kuang, Y., Zheng, Y., & Su, B. (2005) · Gene · doi:10.1016/j.gene.2005.06.045 · Cited by 39