The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Restriction of an Extinct Retrovirus by the Human TRIM5α Antiviral Protein
Abstract
Primate genomes contain a large number of endogenous retroviruses and encode evolutionarily dynamic proteins that provide intrinsic immunity to retroviral infections. We report here the resurrection of the core protein of a 4-million-year-old endogenous virus from the chimpanzee genome and show that the human variant of the intrinsic immune protein TRIM5α can actively prevent infection by this virus. However, we suggest that selective changes that have occurred in the human lineage during the acquisition of resistance to this virus, and perhaps similar viruses, may have left our species more susceptible to infection by human immunodeficiency virus type 1 (HIV-1).
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“Indeed, human TRIM5α has been shown to bind the capsid of a resurrected ERV from the chimpanzee genome 61.”
From Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis (2013) · cites this paper as [61]
Citations
Cites
The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys
Stremlau, M. H., Owens, C. M., Perron, M. J., Kießling, M. K., Autissier, P., & Sodroski, J. (2004) · Nature · doi:10.1038/nature02343 · Cited by 1,810
Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1
Keele, B. F., Heuverswyn, F. V., Li, Y., Bailes, E., Takehisa, J., Santiago, M. L., Bibollet‐Ruche, F., Chen, Y., Wain, L. V., Liégeois, F., et al. (2006) · Science · doi:10.1126/science.1126531 · Cited by 955
Stremlau, M. H., Perron, M. J., Lee, M. N., Li, Y., Song, B., Javanbakht, H., Diaz‐Griffero, F., Anderson, D. J., Sundquist, W. I., & Sodroski, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509996103 · Cited by 736
Sawyer, S. L., Wu, L. I., Emerman, M., & Malik, H. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409853102 · Cited by 688
Self-citationAncient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G
Sawyer, S. L., Emerman, M., & Malik, H. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020275 · Cited by 485
Self-citationA Single Amino Acid Change in the SPRY Domain of Human Trim5α Leads to HIV-1 Restriction
Yap, M. W., Nisole, S., & Stoye, J. P. (2005) · Current Biology · doi:10.1016/j.cub.2004.12.042 · Cited by 408
SIV infection in wild gorillas
Heuverswyn, F. V., Li, Y., Neel, C., Bailes, E., Keele, B. F., Liu, W., Loul, S., Butel, C., Liégeois, F., Bienvenue, Y., et al. (2006) · Nature · doi:10.1038/444164a · Cited by 408
Stremlau, M. H., Perron, M. J., Welikala, S., & Sodroski, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.3139-3145.2005 · Cited by 372
Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5α
Hatziioannou, T., Pérez-Caballero, D., Yang, A., Cowan, S., & Bieniasz, P. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402361101 · Cited by 371
Reconstitution of an Infectious Human Endogenous Retrovirus
Lee, Y. N., & Bieniasz, P. D. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030010 · Cited by 311
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Endogenous viruses: insights into viral evolution and impact on host biology
Feschotte, C., & Gilbert, C. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3199 · Cited by 918
Rules of engagement: molecular insights from host–virus arms races
Daugherty, M. D., & Malik, H. S. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155522 · Cited by 515
Self-citationEffects of Retroviruses on Host Genome Function
Jern, P., & Coffin, J. M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091501 · Cited by 499
Origins and evolutionary consequences of ancient endogenous retroviruses
Johnson, W. E. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0189-2 · Cited by 425
High-resolution comparative analysis of great ape genomes
Kronenberg, Z. N., Fiddes, I. T., Gordon, D., Murali, S., Cantsilieris, S., Meyerson, O. S., Underwood, J. G., Nelson, B. J., Chaisson, M. J. P., Dougherty, M. L., et al. (2018) · Science · doi:10.1126/science.aar6343 · Cited by 350
Metadata
- Authors
- Kaiser, S. M., Malik, H. S., & Emerman, M.
- Affiliations
- University of Washington (US)
- Corresponding author
- Emerman, Michael
- Venue
- Science
- Published
- 2007-06-22
- Volume
- 316
- Issue
- 5832
- Pages
- 1756-1758
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013556374
- Cited by
- 145
- References
- 22
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 17 · 2012: 16
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- TRIM5α, endogenous retroviruses, retroviral restriction, intrinsic immunity, chimpanzee genome, HIV-1 susceptibility, antiviral proteins, primate evolution, host-virus coevolution
- MeSH terms
- Tripartite Motif Proteins, Antiviral Restriction Factors, Animals, Base Sequence, Carrier Proteins, Cats, Cell Line, Pan troglodytes, Disease Susceptibility, DNA, Biological Evolution, Gorilla gorilla, Humans, Immunity, Innate, Macaca mulatta, Molecular Sequence Data, Retroviridae Infections, HIV-1, HIV Infections, Evolution, Molecular, Endogenous Retroviruses, Ubiquitin-Protein Ligases
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