Built to Run, Not Fail
Abstract
Networks of genes that control organism development are organized in a basic architecture that is conserved across processes and species.
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In sea urchins endoderm cells are prevented from expressing mesoderm genes by foxa repression of gcm, whereas in sea stars endoderm cells are also prevented from expressing mesoderm genes, but by gatae (possibly indirectly) blocking gatac and ets1.
“In sea urchins endoderm cells are prevented from expressing mesoderm genes by foxa repression of gcm (22, 23), whereas in sea stars endoderm cells are also prevented from expressing mesoderm genes, but not by foxa : instead it is gatae that executes the exclusion function (possibly indirectly), by blocking expression of gatac and ets1 .”
From Evolutionary plasticity of developmental gene regulatory network architecture (2007) · cites this paper as [23]
The sea urchin mesoderm, endoderm, and oral/aboral ectoderm specification GRNs are deep, layered, and hierarchical.
“The GRNs underlying specification of the mesoderm, endoderm1,2,8 and of the oral and aboral ectoderm9 of the sea urchin embryo are similarly deep, layered and hierarchical.”
From Emerging properties of animal gene regulatory networks (2010) · cites this paper as [9]
Cites
Gene Regulatory Networks and the Evolution of Animal Body Plans
Davidson, E. H., & Erwin, D. H. (2006) · Science · doi:10.1126/science.1113832 · Cited by 1,207 · see citing works
Self-citationRepression of mesodermal fate by<i>foxa</i>, a key endoderm regulator of the sea urchin embryo
Oliveri, P., Walton, K. D., Davidson, E. H., & McClay, D. R. (2006) · Development · doi:10.1242/dev.02577 · Cited by 141 · see citing works
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Emerging properties of animal gene regulatory networks
Davidson, E. H. (2010) · Nature · doi:10.1038/nature09645 · Cited by 579 · see citing works
Self-citationGlobal regulatory logic for specification of an embryonic cell lineage
Oliveri, P., Tu, Q., & Davidson, E. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711220105 · Cited by 381 · see citing works
Self-citationEvolutionary plasticity of developmental gene regulatory network architecture
Hinman, V. F., & Davidson, E. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709994104 · Cited by 154 · see citing works
Self-citationModeling the dynamics of transcriptional gene regulatory networks for animal development
Ben-Tabou de-Leon, S., & Davidson, E. H. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.043 · Cited by 99 · see citing works
Self-citationEvolutionary innovation and stability in animal gene networks
Davidson, E. H., & Erwin, D. H. (2010) · Journal of Experimental Zoology Part B: Molecular and Developmental Evolution · doi:10.1002/jez.b.21329 · Cited by 58 · see citing works
Self-citation
- Authors
- Oliveri, P., & Davidson, E. H.
- Affiliations
- California Institute of Technology (US)
- ORCID
- Oliveri, Paola
- Venue
- Science
- Published
- 2007-03-16
- Volume
- 315
- Issue
- 5818
- Pages
- 1510-1511
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1814963759
- Cited by
- 41
- References
- 2
- Citations by year
- 2020: 2 · 2019: 1 · 2016: 1 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institutes of Health (5p01hd037105-20)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37105)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- gene regulatory networks, developmental gene networks, network architecture, evolutionary conservation, developmental biology, gene regulatory network evolution
- MeSH terms
- Animals, Genes, Regulator, Repressor Proteins, Transcription Factors, Signal Transduction, Embryonic Development, Gene Regulatory Networks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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