The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain
Open accessAbstract
The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.
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ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
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Cited by
Why do many psychiatric disorders emerge during adolescence?
Paus, T., Keshavan, M., & Giedd, J. N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2513 · Cited by 3,123
Mechanisms and Functional Implications of Adult Neurogenesis
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Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
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Human Hippocampal Neurogenesis Persists throughout Aging
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Metadata
- Authors
- Manganas, L. N., Zhang, X., Li, Y., Hazel, R. D., Smith, S. D., Wagshul, M. E., Henn, F., Benveniste, H., Djurić, P. M., Enikolopov, G., & Maletić-Savatić, M.
- Venue
- Science
- Published
- 2007-11-09
- Volume
- 318
- Issue
- 5852
- Pages
- 980-985
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963724707
- Cited by
- 484
- References
- 25
- FWCI
- 36.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Manganas, L. N., Zhang, X., Li, Y., Hazel, R. D., Smith, S. D., Wagshul, M. E., Henn, F., Benveniste, H., Djurić, P. M., Enikolopov, G., & Maletić-Savatić, M. (2007). Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain. Science. https://doi.org/10.1126/science.1147851
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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