New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

Deng, Wei; Aimone, James B.; Gage, Fred H.

doi:10.1038/nrn2822

Cited by 2,120Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

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Deng, Wei, Aimone, James B., Gage, Fred H.·2010·Nature reviews. Neuroscience

DOI 10.1038/nrn2822PMC PMC2886712

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Abstract

The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an important role for adult hippocampal neurogenesis in learning and memory, but its specific function in these processes has remained elusive. In this article, we summarize recent progress in this area, including advances based on behavioural studies and insights provided by computational modelling. Increasingly, evidence suggests that newborn neurons might be involved in hippocampal functions that are particularly dependent on the dentate gyrus, such as pattern separation. Furthermore, newborn neurons at different maturation stages may make distinct contributions to learning and memory. In particular, computational studies suggest that, before newborn neurons are fully mature, they might function as a pattern integrator by introducing a degree of similarity to the encoding of events that occur closely in time.

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These critical regions for memory retention and retrieval are highly vulnerable to Aβ and tau pathology.
“These critical regions for memory retention and retrieval are highly vulnerable to Aβ and tau pathology25,26,27.”
From The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway (2025) · cites this paper as [25]
The review’s section on computational models of adult-born dentate granule cell function discusses hippocampal memory retrieval, and its Conclusions and future directions section says Alzheimer’s disease affects human hippocampal neurogenesis. Neither passage says these regions are highly vulnerable to Aβ or tau pathology; searches for those terms found no supporting passage in our copy. Page numbers were unavailable. (LLM, conf=0.82)
Experimental — accuracy not yet measured
The hippocampus plays a central role in encoding and storage of spatial and episodic memory.
“the hippocampus plays a central role in the encoding and storage of certain types of memory, including spatial and episodic memory [1], [2].”
From Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development (2012) · cites this paper as [1]
The proliferation of adult-born granule cells is thought to play an important role in hippocampal functioning.
“The proliferation of adult-born granule cells is thought to play an important role in hippocampal functioning (Deng et al., 2010; Oomen et al., 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Deng et al., 2010
Inhibiting the rate of cell proliferation in mice was sufficient to impair pattern separation.
“For example, inhibiting the rate of cell proliferation in mice was sufficient to impair pattern separation (Deng et al., 2010) and block AE-induced improvements in spatial (Clark et al., 2009) and contextual (Wojtowicz et al., 2008) memory performance, but only in conditions in which the task required fine spatial discriminations (i.e., where pattern separation was necessary; Creer et al., 2010).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Deng et al., 2010
Inhibition or ablation of neurogenesis impairs performance on spatial and contextual memory tasks.
“Animal models have demonstrated that the inhibition or ablation of neurogenesis impairs performance on spatial and contextual memory tasks while improved performances on these tasks are seen when neurogenesis is stimulated (Deng et al., 2010; Snyder and Cameron, 2012; Aimone et al., 2014; Vadodaria and Jessberger, 2014; Kent et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Deng et al., 2010

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Neural networks and physical systems with emergent collective computational abilities.
Hopfield, J. J. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.8.2554 · Cited by 19,270 · see citing works
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376 · see citing works
Mammalian neural stem cells.
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 3,949 · see citing works
Self-citation
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880 · see citing works
Self-citation
Be smart, exercise your heart: Exercise effects on brain and cognition
Hillman, C. H., Erickson, K. I., & Kramer, A. F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2298 · Cited by 3,563 · see citing works
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,513 · see citing works
Self-citation
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111 · see citing works
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
Self-citation
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works
Self-citation
Simple memory: a theory for archicortex
Marr, D. (1971) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1971.0078 · Cited by 2,771 · see citing works
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works
Self-citation
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works
Learning enhances adult neurogenesis in the hippocampal formation
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999) · Nature Neuroscience · doi:10.1038/6365 · Cited by 2,157 · see citing works
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works
Self-citation
Neurogenesis in the adult is involved in the formation of trace memories
Shors, T. J., Miesegaes, G. R., Beylin, A. V., Zhao, M., Rydel, T. A., & Gould, E. (2001) · Nature · doi:10.1038/35066584 · Cited by 2,014 · see citing works
Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus
Parent, J. M., Yu, T. W., Leibowitz, R. T., Geschwind, D. H., Sloviter, R. S., & Lowenstein, D. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03727.1997 · Cited by 1,853 · see citing works
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642 · see citing works
Self-citation
Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
Leutgeb, J. K., Leutgeb, S., Moser, M.-B., & Moser, E. I. (2007) · Science · doi:10.1126/science.1135801 · Cited by 1,601 · cited 1× · see citing works
“Recent experimental evidence also supports the pattern separation function of the dentate gyrus in information processin”
Result
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611721104 · Cited by 1,353 · see citing works
Self-citation
Hippocampal synaptic enhancement and information storage within a distributed memory system
McNaughton, B. L., & Morris, R. G. M. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90011-7 · Cited by 1,304 · see citing works
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292 · see citing works
Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267 · see citing works
GABA regulates synaptic integration of newly generated neurons in the adult brain
Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G., & Song, H. (2005) · Nature · doi:10.1038/nature04404 · Cited by 1,261 · see citing works
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
Zhao, C., Teng, E. M., Summers, R. G., Ming, G.-L., & Gage, F. H. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3648-05.2006 · Cited by 1,257 · see citing works
Self-citation
Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat
Cameron, H. A., Woolley, C. S., McEwen, B. S., & Gould, E. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90335-d · Cited by 1,215 · see citing works
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., & Kageyama, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2185 · Cited by 1,054 · see citing works
Pattern Separation in the Human Hippocampal CA3 and Dentate Gyrus
Bakker, A., Kirwan, C. B., Miller, M. I., & Stark, C. E. L. (2008) · Science · doi:10.1126/science.1152882 · Cited by 1,050 · see citing works
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
Saxe, M. D., Battaglia, F., Wang, J.-W., Malleret, G., David, D. J., Monckton, J. E., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., Santarelli, L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607207103 · Cited by 1,020 · see citing works
GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain
Garcia, A. D. R., Doan, N., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 990 · see citing works
Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
McHugh, T. J., Jones, M. W., Quinn, J. J., Balthasar, N., Coppari, R., Elmquist, J. K., Lowell, B. B., Fanselow, M. S., Wilson, M. A., & Tonegawa, S. (2007) · Science · doi:10.1126/science.1140263 · Cited by 958 · see citing works
A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.002 · Cited by 927 · see citing works
Hippocampal conjunctive encoding, storage, and recall: Avoiding a trade‐off
O'Reilly, R. C., & McClelland, J. L. (1994) · Hippocampus · doi:10.1002/hipo.450040605 · Cited by 914 · see citing works
The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)
Amaral, D. G., Scharfman, H. E., & Lavenex, P. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63001-5 · Cited by 888 · see citing works
Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
Kee, N., Teixeira, C. M., Wang, A. H., & Frankland, P. W. (2007) · Nature Neuroscience · doi:10.1038/nn1847 · Cited by 875 · see citing works
A role for adult neurogenesis in spatial long-term memory
Snyder, J. S., Hong, N. S., McDonald, R. J., & Wojtowicz, J. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.009 · Cited by 854 · see citing works
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning
Shors, T. J., Townsend, D. A., Zhao, M., Kozorovitskiy, Y., & Gould, E. (2002) · Hippocampus · doi:10.1002/hipo.10103 · Cited by 853 · see citing works
Spatial selectivity of unit activity in the hippocampal granular layer
Jung, M. W., & McNaughton, B. L. (1993) · Hippocampus · doi:10.1002/hipo.450030209 · Cited by 789 · see citing works
Neurons born in the adult dentate gyrus form functional synapses with target cells
Toni, N., Laplagne, D. A., Zhao, C., Lombardi, G., Ribak, C. E., Gage, F. H., & Schinder, A. F. (2008) · Nature Neuroscience · doi:10.1038/nn.2156 · Cited by 741 · see citing works
Self-citation
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Rola, R., Raber, J., Rizk‐Jackson, A., Otsuka, S., VandenBerg, S. R., Morhardt, D. R., & Fike, J. R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.005 · Cited by 709 · see citing works
Radiation-Induced Cognitive Impairments are Associated with Changes in Indicators of Hippocampal Neurogenesis
Raber, J., Rola, R., LeFevour, A., Morhardt, D. R., Curley, J., Mizumatsu, S., VandenBerg, S. R., & Fike, J. R. (2004) · Radiation Research · doi:10.1667/rr3206 · Cited by 706 · see citing works
Computational constraints suggest the need for two distinct input systems to the hippocampal CA3 network
Treves, A., & Rolls, E. T. (1992) · Hippocampus · doi:10.1002/hipo.450020209 · Cited by 702 · see citing works
Neuronal differentiation in the adult hippocampus recapitulates embryonic development
Espósito, M. S., Piatti, V. C., Laplagne, D. A., Morgenstern, N. A., Ferrari, C. C., Pitossi, F. J., & Schinder, A. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3114-05.2005 · Cited by 679 · see citing works
Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells
Deisseroth, K., Singla, S., Toda, H., Monje, M., Palmer, T. D., & Malenka, R. C. (2004) · Neuron · doi:10.1016/s0896-6273(04)00266-1 · Cited by 674 · see citing works
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
Jessberger, S., Clark, R. E., Broadbent, N. J., Clemenson, G. D., Consiglio, A., Lie, D. C., Squire, L. R., & Gage, F. H. (2009) · Learning & Memory · doi:10.1101/lm.1172609 · Cited by 654 · see citing works
Self-citation
Potential role for adult neurogenesis in the encoding of time in new memories
Aimone, J. B., Wiles, J., & Gage, F. H. (2006) · Nature Neuroscience · doi:10.1038/nn1707 · Cited by 644 · see citing works
Self-citation
Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1
Gilbert, P. E., Kesner, R. P., & Lee, I. (2001) · Hippocampus · doi:10.1002/hipo.1077 · Cited by 641 · see citing works
Functional significance of adult neurogenesis
Kempermann, G., Wiskott, L., & Gage, F. H. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.001 · Cited by 630 · see citing works
Self-citation
Circuit-breakers: optical technologies for probing neural signals and systems
Zhang, F., Aravanis, A. M., Adamantidis, A., de Lecea, L., & Deisseroth, K. A. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2192 · Cited by 623 · see citing works
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
Tashiro, A., Sandler, V. M., Toni, N., Zhao, C., & Gage, F. H. (2006) · Nature · doi:10.1038/nature05028 · Cited by 620 · see citing works
Self-citation
A computational theory of hippocampal function, and empirical tests of the theory
Rolls, E. T., & Kesner, R. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.04.005 · Cited by 608 · see citing works
Exercise and the brain: something to chew on
van Praag, H. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.007 · Cited by 599 · see citing works
Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies
Garthe, A., Behr, J., & Kempermann, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005464 · Cited by 597 · see citing works
Spatial Relational Memory Requires Hippocampal Adult Neurogenesis
Dupret, D., Revest, J., Koehl, M., Ichas, F., Giorgi, F. D., Costet, P., Abrous, D. N., & Piazza, P. V. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001959 · Cited by 595 · see citing works
Inhibition of neurogenesis interferes with hippocampus‐dependent memory function
Winocur, G., Wojtowicz, J. M., Sekeres, M. J., Snyder, J. S., & Wang, S. Z. (2006) · Hippocampus · doi:10.1002/hipo.20163 · Cited by 580 · see citing works
Synapse formation on neurons born in the adult hippocampus
Toni, N., Teng, E. M., Bushong, E. A., Aimone, J. B., Zhao, C., Consiglio, A., van Praag, H., Martone, M. E., Ellisman, M. H., & Gage, F. H. (2007) · Nature Neuroscience · doi:10.1038/nn1908 · Cited by 579 · see citing works
Self-citation
A role for adult TLX-positive neural stem cells in learning and behaviour
Zhang, C., Zou, Y., He, W., Gage, F. H., & Evans, R. M. (2008) · Nature · doi:10.1038/nature06562 · Cited by 523 · see citing works
Self-citation
Experience-Specific Functional Modification of the Dentate Gyrus through Adult Neurogenesis: A Critical Period during an Immature Stage
Tashiro, A., Makino, H., & Gage, F. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4941-06.2007 · Cited by 521 · see citing works
Self-citation
New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment
Bruel‐Jungerman, E., Laroche, S., & Rampon, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03875.x · Cited by 505 · see citing works
Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain
Deng, W., Saxe, M. D., Gallina, I. S., & Gage, F. H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3362-09.2009 · Cited by 493 · see citing works
Self-citation
Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat
Madsen, T. M., Kristjansen, P. E. G., Bolwig, T. G., & Wörtwein, G. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00199-4 · Cited by 493 · see citing works
Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning
Nakashiba, T., Young, J. Z., McHugh, T. J., Buhl, D. L., & Tonegawa, S. (2008) · Science · doi:10.1126/science.1151120 · Cited by 492 · see citing works
Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory
北村, 貴., Saitoh, Y., Takashima, N., Murayama, A., Niibori, Y., Ageta, H., Sekiguchi, M., Sugiyama, H., & Inokuchi, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.020 · Cited by 489 · see citing works
Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain
Manganas, L. N., Zhang, X., Li, Y., Hazel, R. D., Smith, S. D. B., Wagshul, M. E., Henn, F. A., Benveniste, H., Djurić, P. M., Enikolopov, G., et al. (2007) · Science · doi:10.1126/science.1147851 · Cited by 486 · see citing works
Post-Natal Origin of Microneurones in the Rat Brain
Altman, J., & Das, G. D. (1965) · Nature · doi:10.1038/207953a0 · Cited by 481 · see citing works
Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo
Henze, D. A., Wittner, L., & Buzsáki, G. (2002) · Nature Neuroscience · doi:10.1038/nn887 · Cited by 480 · see citing works
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
Meshi, D., Drew, M. R., Saxe, M., Ansorge, M. S., David, D. J. P., Santarelli, L., Malapani, C., Moore, H. M., & Hen, R. (2006) · Nature Neuroscience · doi:10.1038/nn1696 · Cited by 458 · see citing works
Neurogenesis in adulthood: a possible role in learning
Gould, E. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01310-8 · Cited by 430 · see citing works
Adult-Born Hippocampal Neurons Are More Numerous, Faster Maturing, and More Involved in Behavior in Rats than in Mice
Snyder, J. S., Choe, J. S., Clifford, M. A., Jeurling, S. I., Hurley, P., Brown, A., Kamhi, J. F., & Cameron, H. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1768-09.2009 · Cited by 427 · see citing works
Mapping behaviorally relevant neural circuits with immediate-early gene expression
Guzowski, J. F., Timlin, J. A., Roysam, B., McNaughton, B. L., Worley, P. F., & Barnes, C. A. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.018 · Cited by 404 · see citing works
Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons
Dupret, D., Fabre, A., Döbrössy, M. D., Panatier, A., Rodriguez, J. J., Lamarque, S., Lemaire, V., Oliet, S. H. R., Piazza, P., & Abrous, D. N. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050214 · Cited by 387 · see citing works
Age-related production of new granule cells in the adult dentate gyrus
Seki, T., & Arai, Y. (1995) · Neuroreport · doi:10.1097/00001756-199512150-00010 · Cited by 386 · see citing works
Signaling in Adult Neurogenesis
Suh, H., Deng, W., & Gage, F. H. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113256 · Cited by 373 · see citing works
Self-citation
Computational Influence of Adult Neurogenesis on Memory Encoding
Aimone, J. B., Wiles, J., & Gage, F. H. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.026 · Cited by 370 · see citing works
Self-citation
Early age-related changes in adult hippocampal neurogenesis in C57 mice
Abdallah, N. M. ‐. B., Slomianka, L., Vyssotski, A. L., & Lipp, H. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.002 · Cited by 368 · see citing works
Impaired Spatial Representation in CA1 after Lesion of Direct Input from Entorhinal Cortex
Brun, V. H., Leutgeb, S., Wu, H., Schwarcz, R. M., Witter, M. P., Moser, E. I., & Moser, M. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.034 · Cited by 364 · see citing works
Aberrant seizure‐induced neurogenesis in experimental temporal lobe epilepsy
Parent, J. M., Elliott, R. C., Pleasure, S. J., Barbaro, N. M., & Lowenstein, D. H. (2005) · Annals of Neurology · doi:10.1002/ana.20699 · Cited by 363 · see citing works
Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling
Jessberger, S., Zhao, C., Toni, N., Clemenson, G. D., Li, Y., & Gage, F. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2002-07.2007 · Cited by 360 · see citing works
Self-citation
Adult neurogenesis and the olfactory system
Whitman, M. C., & Greer, C. A. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.07.003 · Cited by 360 · see citing works
Integration of New Neurons into Functional Neural Networks
Ramı́rez-Amaya, V., Marrone, D. F., Gage, F. H., Worley, P. F., & Barnes, C. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2195-06.2006 · Cited by 332 · see citing works
Self-citation
Adult‐born hippocampal neurons mature into activity‐dependent responsiveness
Jessberger, S., & Kempermann, G. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.02986.x · Cited by 330 · see citing works
GABA-cAMP Response Element-Binding Protein Signaling Regulates Maturation and Survival of Newly Generated Neurons in the Adult Hippocampus
Jagasia, R., Steib, K., Englberger, E., Herold, S., Faus-Keßler, T., Saxe, M., Gage, F. H., Song, H., & Lie, D. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1054-09.2009 · Cited by 328 · see citing works
Self-citation
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus
Bruel‐Jungerman, E., Davis, S., Rampon, C., & Laroche, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0782-06.2006 · Cited by 296 · see citing works
A functional hypothesis for adult hippocampal neurogenesis: Avoidance of catastrophic interference in the dentate gyrus
Wiskott, L., Rasch, M. J., & Kempermann, G. (2006) · Hippocampus · doi:10.1002/hipo.20167 · Cited by 292 · see citing works
Learning Enhances the Survival of New Neurons beyond the Time when the Hippocampus Is Required for Memory
Leuner, B., Mendolia‐Loffredo, S., Kozorovitskiy, Y., Samburg, D., Gould, E., & Shors, T. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0204-04.2004 · Cited by 289 · see citing works
GABAergic Signaling to Newborn Neurons in Dentate Gyrus
Overstreet‐Wadiche, L., Bromberg, D. A., Bensen, A. L., & Westbrook, G. L. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00633.2005 · Cited by 270 · see citing works
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Considerations arising from a complementary learning systems perspective on hippocampus and neocortex
McClelland, J. L., & Goddard, N. (1996) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:6 · Cited by 262 · see citing works
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Nissant, A., Bardy, C., Katagiri, H., Murray, K., & Lledo, P. (2009) · Nature Neuroscience · doi:10.1038/nn.2298 · Cited by 252 · see citing works
Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date
Döbrössy, M. D., Drapeau, E., Aurousseau, C., Moal, M. L., Piazza, P. V., & Abrous, D. N. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001419 · Cited by 252 · see citing works
A computational principle for hippocampal learning and neurogenesis
Becker, S. (2005) · Hippocampus · doi:10.1002/hipo.20095 · Cited by 244 · see citing works
Paradoxical influence of hippocampal neurogenesis on working memory
Saxe, M., Malleret, G., Vronskaya, S., Mendez‐David, I., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., & Hen, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611718104 · Cited by 244 · see citing works
Morpho-functional characterization of neuronal cells at different stages of maturation in granule cell layer of adult rat dentate gyrus
Ambrogini, P., Lattanzi, D., Ciuffoli, S., Agostini, D., Bertini, L., Stocchi, V., Santi, S., & Cuppini, R. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.039 · Cited by 222 · see citing works
A model of hippocampal neurogenesis in memory and mood disorders
Becker, S., & Wojtowicz, J. M. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.10.013 · Cited by 213 · see citing works
Interneurons of the dentate gyrus: an overview of cell types, terminal fields and neurochemical identity
Houser, C. R. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63013-1 · Cited by 209 · see citing works
Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain
Faulkner, R. L., Jang, M., Liu, X.-B., Duan, X., Sailor, K. A., Kim, J. Y., Ge, S., Jones, E. G., Ming, G., Song, H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806658105 · Cited by 208 · see citing works
A behavioral analysis of dentate gyrus function
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Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory
Trouche, S. G., Bontempi, B., Roullet, P., & Rampon, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811054106 · Cited by 192 · see citing works
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Myers, C. E., & Scharfman, H. E. (2008) · Hippocampus · doi:10.1002/hipo.20516 · Cited by 188 · see citing works
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Vecchioli, S. F., Saraulli, D., Costanzi, M., Pacioni, S., Cinà, I., Aceti, M., Micheli, L., Bacci, A., Cestari, V., & Tirone, F. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060246 · Cited by 186 · see citing works
The effects of exercise and stress on the survival and maturation of adult‐generated granule cells
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Hippocampus-dependent learning promotes survival of new neurons in the dentate gyrus at a specific time during cell maturation
Epp, J. R., Spritzer, M. D., & Galea, L. A. M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.046 · Cited by 176 · see citing works
Environmental influence on L1 retrotransposons in the adult hippocampus
Muotri, A. R., Zhao, C., Marchetto, M. C., & Gage, F. H. (2009) · Hippocampus · doi:10.1002/hipo.20564 · Cited by 175 · see citing works
Self-citation
Long-term potentiation in the hippocampus
Voronin, L. L. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90099-4 · Cited by 169 · see citing works
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Chambers, R. A., Potenza, M. N., Hoffman, R. E., & Miranker, W. L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300358 · Cited by 159 · see citing works
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Scobie, K. N., Hall, B. J., Wilke, S. A., Klemenhagen, K. C., Fujii‐Kuriyama, Y., Ghosh, A., Hen, R., & Sahay, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2260-09.2009 · Cited by 144 · see citing works
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Ko, H.-G., Jang, D.-J., Son, J., Kwak, C., Choi, J.-H., Ji, Y.-H., Lee, Y.-S., Son, H., & Kaang, B. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-1 · Cited by 141 · see citing works
Computational Approach
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_1162 · Cited by 116 · see citing works
Social isolation prevents exercise‐induced proliferation of hippocampal progenitor cells in female rats
Leasure, J. L., & Decker, L. (2009) · Hippocampus · doi:10.1002/hipo.20563 · Cited by 112 · see citing works
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Schinder, A. F., & Gage, F. H. (2004) · Physiology · doi:10.1152/physiol.00012.2004 · Cited by 108 · see citing works
Self-citation
Input-Specific GABAergic Signaling to Newborn Neurons in Adult Dentate Gyrus
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Enhanced proliferation of progenitor cells following long-term potentiation induction in the rat dentate gyrus
Chun, S., Sun, W., Park, J., & JUNG, M. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.05.005 · Cited by 84 · see citing works
Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus
Dupret, D., Montaron, M., Drapeau, E., Aurousseau, C., Moal, M. L., Piazza, P., & Abrous, D. N. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04262.x · Cited by 73 · see citing works
Functional Maturation of the First Synapse in Olfaction: Development and Adult Neurogenesis
Grubb, M. S., Nissant, A., Murray, K., & Lledo, P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5550-07.2008 · Cited by 72 · see citing works
Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation
Warner‐Schmidt, J. L., Madsen, T. M., & Duman, R. S. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06118.x · Cited by 72 · see citing works
A putative role for neurogenesis in neurocomputational terms: Inferences from a hippocampal model
Weisz, V. I., & Argibay, P. F. (2009) · Cognition · doi:10.1016/j.cognition.2009.05.001 · Cited by 66 · see citing works
Temporal Discontiguity Is neither Necessary nor Sufficient for Learning-Induced Effects on Adult Neurogenesis
Leuner, B., Waddell, J., Gould, E., & Shors, T. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2781-06.2006 · Cited by 60 · see citing works
Hippocampal Neurogenesis and Depression
Sahay, A., & Hen, R. (2008) · Novartis Foundation symposium · doi:10.1002/9780470751251.ch12 · Cited by 51 · see citing works
Electroconvulsive stimuli enhance both neuropeptide Y receptor Y1 and Y2 messenger RNA expression and levels of binding in the rat hippocampus
Madsen, T. M., Greisen, M. H., Nielsen, S. M., Bolwig, T. G., & Mikkelsen, J. D. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00078-6 · Cited by 51 · see citing works
Granule neurons generated during development extend divergent axon collaterals to hippocampal area CA3
Hastings, N. B., Seth, M. I., Tanapat, P., Rydel, T. A., & Gould, E. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10386 · Cited by 37 · see citing works
Apoptosis, neurogenesis, and information content in Hebbian networks
Crick, C., & Miranker, W. L. (2005) · Biological Cybernetics · doi:10.1007/s00422-005-0026-8 · Cited by 24 · see citing works
Is there a support vector machine hiding in the dentate gyrus?
Baker, J. L. (2003) · Neurocomputing · doi:10.1016/s0925-2312(02)00733-6 · Cited by 15 · see citing works
Something to chew on
Lieberman, D. E. (2004) · Nature · doi:10.1038/431400a · Cited by 8 · see citing works
Comment on “potential role for adult neurogenesis in the encoding of time in new memories”
Friedman, W. J. (2007) · Hippocampus · doi:10.1002/hipo.20280 · Cited by 7 · see citing works

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Research works printed but not linked: 4

[3]Enikolopov G Overstreet Wadiche L Gage FH Kempermann G Song H Adult Neurogenesis 2008 81 100 Cold Spring Harbor Laboratory Press New York
[4]Kuhn HG Peterson DA Gage FH Kempermann G Song H Adult Neurogenesis 2008 25 47 Cold Spring Harbor Laboratory Press New York
[5]Zhao C Gage FH Kempermann G Song H Adult Neurogenesis 2008 101 117 Cold Spring Harbor Laboratory Press New York
[76]Aimone JB Wiskott L Gage FH Kempermann G Song H Adult Neurogenesis 2008 101 117 Cold Spring Harbor Laboratory Press New York

Sorted by citations

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Parisi, G. I., Kemker, R., Part, J. L., Kanan, C., & Wermter, S. (2019) · Neural Networks · doi:10.1016/j.neunet.2019.01.012 · Cited by 3,117 · see citing works
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651 · see citing works
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Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works
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Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works
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Millan, M. J., Agid, Y., Brüne, M., Bullmore, E. T., Carter, C. S., Clayton, N. S., Connor, R., Davis, S., Deakin, B., DeRubeis, R. J., et al. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3628 · Cited by 1,292 · see citing works
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Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030 · see citing works
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Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L. P., Park, R., Vinciguerra, M., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.012 · Cited by 850 · see citing works
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Fernandez, A. M., & Torres-Alemán, I. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3209 · Cited by 872 · see citing works
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Self-citation
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The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
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Aimone, J. B., Deng, W., & Gage, F. H. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.04.003 · Cited by 303 · see citing works
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Addis, D. R., & Schacter, D. L. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00173 · Cited by 285 · see citing works
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Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G., & Dinan, T. G. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00490 · Cited by 271 · see citing works
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Stein, L. R., & Imai, S. (2014) · The EMBO Journal · doi:10.1002/embj.201386917 · Cited by 265 · see citing works
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Stancu, I.-C., Vasconcelos, B., Terwel, D., & Dewachter, I. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-51 · Cited by 256 · see citing works
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Oomen, C. A., Hvoslef-Eide, M., Heath, C. J., Mar, A. C., Horner, A. E., Bussey, T. J., & Saksida, L. M. (2013) · Nature Protocols · doi:10.1038/nprot.2013.124 · Cited by 193 · see citing works
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Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice
Kohman, R. A., DeYoung, E. K., Bhattacharya, T. K., Peterson, L. N., & Rhodes, J. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.006 · Cited by 176 · see citing works
Plastic and neuroprotective mechanisms involved in the therapeutic effects of cannabidiol in psychiatric disorders
Campos, A. C., Fogaça, M. V., Scarante, F. F., Joca, S. R. L., Sales, A. J., Gomes, F. V., Sonego, A. B., Rodrigues, N. S., Galve-Roperh, I., & Guimarães, F. S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00269 · Cited by 175 · see citing works
A time to remember: The role of circadian clocks in learning and memory.
Smarr, B. L., Jennings, K. J., Driscoll, J. R., & Kriegsfeld, L. J. (2014) · Behavioral Neuroscience · doi:10.1037/a0035963 · Cited by 166 · see citing works
Reduced Adult Hippocampal Neurogenesis and Working Memory Deficits in theDgcr8-Deficient Mouse Model of 22q11.2 Deletion-Associated Schizophrenia Can Be Rescued by IGF2
Ouchi, Y., Banno, Y., Shimizu, Y., Ando, S., Hasegawa, H., Adachi, K., & Iwamoto, T. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2700-12.2013 · Cited by 155 · see citing works
Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment
Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155 · see citing works
“Key mechanisms at both the cellular and molecular level will be discussed below in terms of their contribution to AE-induced enhancements in hippocampal functioning.”
Influential
CX3CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment
Maggi, L. (2011) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2011.00022 · Cited by 149 · see citing works
A role for the hippocampus in encoding simulations of future events
Martin, V. C., Schacter, D. L., Corballis, M. C., & Addis, D. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105816108 · Cited by 144 · see citing works
The effects of physical exercise and cognitive training on memory and neurotrophic factors.
Heisz, J. J., Clark, I. B., Bonin, K., Paolucci, E. M., Michalski, B., Becker, S., & Fahnestock, M. (2017) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01164 · Cited by 144 · see citing works
A Randomized Trial to Examine the Effect of Mifepristone on Neuropsychological Performance and Mood in Patients with Bipolar Depression
Watson, S., Gallagher, P., Porter, R. J., Smith, M. S., Herron, L. J., Bulmer, S., Young, A. H., & Ferrier, I. N. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.029 · Cited by 145 · see citing works
Dorsal vs Ventral Hippocampal Neurogenesis: Implications for Cognition and Mood
Kheirbek, M. A., & Hen, R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.148 · Cited by 140 · see citing works
Functional and Structural Benefits Induced by Omega-3 Polyunsaturated Fatty Acids During Aging
Cutuli, D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160614091311 · Cited by 139 · see citing works
Blood Brain Barrier Permeability of (-)-epigallocatechin Gallate, its Proliferation-Enhancing Activity of Human Neuroblastoma SH-Sy5y Cells, and its Preventive Effect on Age-Related Cognitive Dysfunction in Mice
Pervin, M., Unno, K., Nakagawa, A., Takahashi, Y., Iguchi, K., Yamamoto, H., Hoshino, M., Hara, A., Takagaki, A., Nanjo, F., et al. (2017) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2016.12.012 · Cited by 137 · see citing works
Stress, glucocorticoid receptors, and adult neurogenesis: A balance between excitation and inhibition?
Saaltink, D.-J., & Vreugdenhil, E. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1568-5 · Cited by 127 · see citing works
New perspectives on the biology of fragile X syndrome
Wang, T., Bray, S. M., & Warren, S. T. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.02.002 · Cited by 116 · see citing works
In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.
Rodríguez-Matellán, A., Alcazar, N., Hernández, F., Serrano, M., & Ávila, J. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.09.010 · Cited by 116 · see citing works
Adult neurogenesis: bridging the gap between mice and humans
Jessberger, S., & Gage, F. H. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.07.003 · Cited by 116 · see citing works
Self-citation
Long-term exercise is needed to enhance synaptic plasticity in the hippocampus
Patten, A. R., Sickmann, H., Hryciw, B. N., Kucharsky, T., Parton, R., Kernick, A., & Christie, B. R. (2013) · Learning & Memory · doi:10.1101/lm.030635.113 · Cited by 101 · see citing works
Replay in Deep Learning: Current Approaches and Missing Biological Elements
Hayes, T. L., Krishnan, G. P., Bazhenov, M., Siegelmann, H. T., Sejnowski, T. J., & Kanan, C. (2021) · Neural Computation · doi:10.1162/neco_a_01433 · Cited by 106 · see citing works
From the Bottom-Up: Chemotherapy and Gut-Brain Axis Dysregulation
Bajic, J. E., Johnston, I. N., Howarth, G. S., & Hutchinson, M. R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00104 · Cited by 100 · see citing works
Epilepsy, amyloid-β, and D1 dopamine receptors: a possible pathogenetic link?
Costa, C., Parnetti, L., D'Amelio, M., Tozzi, A., Tantucci, M., Romigi, A., Siliquini, S., Cavallucci, V., Di Filippo, M., Mazzocchetti, P., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.025 · Cited by 94 · see citing works
AAV ablates neurogenesis in the adult murine hippocampus
Johnston, S., Parylak, S. L., Kim, S., Mac, N., Lim, C., Gallina, I., Bloyd, C., Newberry, A., Saavedra, C. D., Novak, O., et al. (2021) · eLife · doi:10.7554/elife.59291 · Cited by 87 · see citing works
Self-citation
At least eighty percent of brain grey matter is modifiable by physical activity: A review study
Batouli, S. A. H., & Saba, V. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.002 · Cited by 92 · see citing works
Adult hippocampal neurogenesis and its role in cognition.
Oomen, C. A., Bekinschtein, P., Kent, B. A., Saksida, L. M., & Bussey, T. J. (2014) · WIREs Cognitive Science · doi:10.1002/wcs.1304 · Cited by 93 · see citing works
Consequences of cancer treatments on adult hippocampal neurogenesis: implications for cognitive function and depressive symptoms
Pereira Dias, G., Hollywood, R., Bevilaqua, M. C. D. N., da Silveira da Luz, A. C. D., Hindges, R., Nardi, A. E., & Thuret, S. (2014) · Neuro-Oncology · doi:10.1093/neuonc/not321 · Cited by 85 · see citing works
The maturation of research into the avian hippocampal formation: Recent discoveries from one of the nature’s foremost navigators
Herold, C., Coppola, V. J., & Bingman, V. P. (2015) · Hippocampus · doi:10.1002/hipo.22463 · Cited by 84 · see citing works
The Role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RA) in Diabetes-Related Neurodegenerative Diseases
Cheng, D., Yang, S., Zhao, X., & Wang, G. (2022) · Drug Design, Development and Therapy · doi:10.2147/dddt.s348055 · Cited by 84 · see citing works
Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer’s disease mice
Kiyota, T., Machhi, J., Lu, Y., Dyavarshetty, B., Nemati, M., Yokoyama, I., Mosley, R. L., & Gendelman, H. E. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.03.009 · Cited by 80 · see citing works
Running improves pattern separation during novel object recognition
Bolz, L., Heigele, S., & Bischofberger, J. (2015) · Brain Plasticity · doi:10.3233/bpl-150010 · Cited by 80 · see citing works
Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know
Alger, B. E. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.220855 · Cited by 82 · see citing works
Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring
Ear, P. H., Chadda, A., Gumusoglu, S. B., Schmidt, M. S., Vogeler, S., Malicoat, J., Kadel, J., Moore, M. M., Migaud, M. E., Stevens, H. E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.007 · Cited by 72 · see citing works
Reelin regulates the maturation of dendritic spines, synaptogenesis and glial ensheathment of newborn granule cells
Bosch, C., Masachs, N., Exposito-Alonso, D., Martínez, A., Teixeira, C. M., Fernaud, I., Pujadas, L., Ulloa, F., Comella, J. X., DeFelipe, J., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw216 · Cited by 70 · see citing works
Molecular and cellular aspects of age-related cognitive decline and Alzheimer’s disease
Hullinger, R., & Puglielli, L. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.008 · Cited by 68 · see citing works
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB
Maimon, R., Chillon-Marinas, C., Snethlage, C. E., Singhal, S. M., McAlonis-Downes, M., Ling, K., Rigo, F., Bennett, C. F., Da Cruz, S., Hnasko, T. S., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00864-y · Cited by 62 · see citing works
Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche
Fatt, M. P., Tran, L. M., Vetere, G., Storer, M. A., Simonetta, J. V., Miller, F. D., Frankland, P. W., & Kaplan, D. R. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.12.010 · Cited by 58 · see citing works
Physical exercise and environment exploration affect synaptogenesis in adult-generated neurons in the rat dentate gyrus: possible role of BDNF
Ambrogini, P., Lattanzi, D., Ciuffoli, S., Betti, M., Fanelli, M., & Cuppini, R. (2013) · Brain Research · doi:10.1016/j.brainres.2013.08.023 · Cited by 61 · see citing works
The elusive engram: what can infantile amnesia tell us about memory?
Callaghan, B. L., Li, S., & Richardson, R. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.007 · Cited by 51 · see citing works
A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling
Wallace Fitzsimons, S. E., Chruścicka, B., Druelle, C., Stamou, P., Nally, K., Dinan, T. G., Cryan, J. F., & Schellekens, H. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.022 · Cited by 49 · see citing works
Lixisenatide improves recognition memory and exerts neuroprotective actions in high-fat fed mice
Lennox, R., Flatt, P. R., & Gault, V. A. (2014) · Peptides · doi:10.1016/j.peptides.2014.08.014 · Cited by 47 · see citing works
Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development
Jain, S., Yoon, S. Y., Zhu, L., Brodbeck, J., Dai, J., Walker, D., & Huang, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046340 · Cited by 43 · see citing works
Physiological impact of CB1 receptor expression by hippocampal GABAergic interneurons
Albayram, Ö., Passlick, S., Bilkei-Gorzo, A., Zimmer, A., & Steinhäuser, C. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-015-1782-5 · Cited by 42 · see citing works
Voluntary exercise followed by chronic stress strikingly increases mature adult-born hippocampal neurons and prevents stress-induced deficits in’ what-when-where’ memory
Castilla-Ortega, E., Rosell-Valle, C., Pedraza, C., Rodríguez de Fonseca, F., Estivill-Torrús, G., & Santín, L. J. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.001 · Cited by 41 · see citing works
The p75 neurotrophin receptor is localized to primary cilia in adult murine hippocampal dentate gyrus granule cells
Chakravarthy, B., Gaudet, C., Ménard, M., Atkinson, T., Chiarini, A., Dal Prà, I., & Whitfield, J. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.081 · Cited by 36 · see citing works
Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?
Pluta, R., Bogucka-Kocka, A., Ułamek-Kozioł, M., Furmaga-Jabłońska, W., Januszewski, S., Brzozowska, J., Jabłoński, M., & Kocki, J. (2015) · Folia Neuropathologica · doi:10.5114/fn.2015.52405 · Cited by 34 · see citing works
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
Naguib, S., Lopez-Lee, C., Torres, E. R., Lee, S.-I., Zhu, J., Zhu, D., Ye, P., Norman, K., Zhao, M., Wong, M. Y., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.05.023 · Cited by 32 · see citing works
Effects of treadmill exercise on neural stem cells, cell proliferation, and neuroblast differentiation in the subgranular zone of the dentate gyrus in cyclooxygenase-2 knockout mice
Nam, S. M., Kim, J. W., Yoo, D. Y., Choi, J. H., Kim, W., Jung, H. Y., Won, M.-H., Hwang, I. K., Seong, J. K., & Yoon, Y. S. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1169-y · Cited by 26 · see citing works
APOE3 - R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition
Naguib, S., Lopez-Lee, C., Torres, E. R., Lee, S.-I., Zhu, J., Zhu, D., Ye, P., Norman, K., Zhao, M., Wong, M. Y., et al. (2024) · doi:10.1101/2024.04.25.591140 · Cited by 25 · see citing works
Location is everything: neurons born during fluoxetine treatment accumulate in regions that do not support spatial learning
Satvat, E., Gheidi, A., Voll, S., Odintsova, I. V., & Marrone, D. F. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.025 · Cited by 18 · see citing works
The long and the short of aberrant ciliogenesis in Huntington disease
Liu, J.-P., & Zeitlin, S. O. (2011) · Journal of Clinical Investigation · doi:10.1172/jci60243 · Cited by 19 · see citing works

Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis
Lichtenwalner, R. J., Forbes, M. E., Bennett, S. A., Lynch, C. D., Sonntag, W. E., & Riddle, D. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00378-5 · Cited by 428 · see citing works
Differential neurogenesis in the adult rat dentate gyrus: an identifiable zone that consistently lacks neurogenesis
Melvin, N. R., Spanswick, S. C., Lehmann, H., & Sutherland, R. J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05363.x · Cited by 8 · see citing works
190. Neurogenesis Inhibits Stress-Responsive Cells in the Ventral Dentate Gyrus
Anacker, C., Luna, V. M., Stevens, G. S., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.209 · Cited by 1 · see citing works
Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice
Bondolfi, L., Ermini, F., Long, J. M., Ingram, D. K., & Jucker, M. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00083-6 · Cited by 264 · see citing works
A combination of running and memantine increases neurogenesis and reduces activation of developmentally-born dentate granule neurons in rats
Cahill, S. P., Martinovic, A., Cole, J. D., Seib, D. R., & Snyder, J. S. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112005 · Cited by 8 · see citing works

Authors: Deng, W., Aimone, J. B., & Gage, F. H.
Affiliations: Salk Institute for Biological Studies (US)
Corresponding author: Gage, Fred H.
ORCID: Deng, Wei
Aimone, James B.
Gage, Fred H.
Venue: Nature reviews. Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2010-03-31
Volume: 11
Issue: 5
Pages: 339-350
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2822
PMC: PMC2886712
OpenAlex: W2026393786
Cited by: 2,120
References: 125
Citations by year: 2026: 38 · 2025: 68 · 2024: 86 · 2023: 75 · 2022: 85 · 2021: 113 · 2020: 143 · 2019: 136 · 2018: 134 · 2017: 166 · 2016: 176 · 2015: 166 · 2014: 181 · 2013: 169 · 2012: 161
FWCI: 14.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation
James S. McDonnell Foundation
National Institute on Aging (AG 020938, R01AG020938)
National Institute of Neurological Disorders and Stroke (R01NS050217, NS050217)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: adult hippocampal neurogenesis, newborn neurons, hippocampus-dependent learning, memory formation, dentate gyrus, pattern separation, pattern integration, neuronal maturation, hippocampal circuitry
MeSH terms: Animals, Hippocampus, Humans, Learning, Memory, Models, Neurological, Neurons, Adult Stem Cells, Neurogenesis

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New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

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