The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A β-Defensin Mutation Causes Black Coat Color in Domestic Dogs
Open accessAbstract
Genetic analysis of mammalian color variation has provided fundamental insight into human biology and disease. In most vertebrates, two key genes, Agouti and Melanocortin 1 receptor ( Mc1r ), encode a ligand-receptor system that controls pigment type-switching, but in domestic dogs, a third gene is implicated, the K locus, whose genetic characteristics predict a previously unrecognized component of the melanocortin pathway. We identify the K locus as β- defensin 103 ( CBD103 ) and show that its protein product binds with high affinity to the Mc1r and has a simple and strong effect on pigment type-switching in domestic dogs and transgenic mice. These results expand the functional role of β-defensins, a protein family previously implicated in innate immunity, and identify an additional class of ligands for signaling through melanocortin receptors.
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Cites
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Genome sequence, comparative analysis and haplotype structure of the domestic dog
members, B. S. P., Lindblad-Toh, K., Wade, C. M., Mikkelsen, T. S., Karlsson, E. K., Jaffe, D. B., Kamal, M., Clamp, M., Chang, J. L., Kulbokas, E. J., et al. (2005) · Nature · doi:10.1038/nature04338 · Cited by 2,568
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809
The cloning of a family of genes that encode the melanocortin receptors
Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) · Science · doi:10.1126/science.1325670 · Cited by 1,635
Evolutionary diversification of the mammalian defensins
Hughes, A. L. (1999) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050010 · Cited by 135
Cited by
Pleiotropy in the melanocortin system, coloration and behavioural syndromes
DUCREST, A., KELLER, L., & ROULIN, A. (2008) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2008.06.001 · Cited by 847
A Simple Genetic Architecture Underlies Morphological Variation in Dogs
Boyko, A. R., Quignon, P., Li, L., Schoenebeck, J. J., Degenhardt, J. D., Lohmueller, K. E., Zhao, K., Brisbin, A., Parker, H. G., vonHoldt, B. M., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000451 · Cited by 494
Geng, L. N., Yao, Z., Snider, L., Fong, A. P., Cech, J. N., Young, J. M., van der Maarel, S. M., Ruzzo, W. L., Gentleman, R. C., Tawil, R., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.013 · Cited by 458
Molecular and Evolutionary History of Melanism in North American Gray Wolves
Anderson, T. M., vonHoldt, B. M., Candille, S. I., Musiani, M., Greco, C., Stahler, D. R., Smith, D. W., Padhukasahasram, B., Randi, E., Leonard, J. A., et al. (2009) · Science · doi:10.1126/science.1165448 · Cited by 416
Self-citationMolecular genetics of human pigmentation diversity
Sturm, R. A. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp003 · Cited by 379
Metadata
- Authors
- Candille, S. I., Kaelin, C. B., Cattanach, B. M., Yu, B., Thompson, D. A., Nix, M. A., Kerns, J. A., Schmutz, S. M., Millhauser, G. L., & Barsh, G. S.
- Venue
- Science
- Published
- 2007-11-30
- Volume
- 318
- Issue
- 5855
- Pages
- 1418-1423
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2137357450
- Cited by
- 354
- References
- 5
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Candille, S. I., Kaelin, C. B., Cattanach, B. M., Yu, B., Thompson, D. A., Nix, M. A., Kerns, J. A., Schmutz, S. M., Millhauser, G. L., & Barsh, G. S. (2007). A β-Defensin Mutation Causes Black Coat Color in Domestic Dogs. Science. https://doi.org/10.1126/science.1147880
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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