The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Stochasticity and Cell Fate
Open accessAbstract
Fundamental to living cells is the capacity to differentiate into subtypes with specialized attributes. Understanding the way cells acquire their fates is a major challenge in developmental biology. How cells adopt a particular fate is usually thought of as being deterministic, and in the large majority of cases it is. That is, cells acquire their fate by virtue of their lineage or their proximity to an inductive signal from another cell. In some cases, however, and in organisms ranging from bacteria to humans, cells choose one or another pathway of differentiation stochastically, without apparent regard to environment or history. Stochasticity has important mechanistic requirements. We speculate on why stochasticity is advantageous—and even critical in some circumstances—to the individual, the colony, or the species.
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Cites
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
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Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952 · cited 1×
“is the persister state, which is observed in E. coli and many other bacteria, including pathogenic bacteria [21, 22 ].”
BackgroundPersister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052
MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision
Johnston, R. J., Chang, S., Etchberger, J. F., Ortiz, C. O., & Hobert, O. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505530102 · Cited by 276
Cited by
Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
Klein, A. M., Mazutis, L., Akartuna, I., Tallapragada, N., Veres, A., Li, V., Peshkin, L., Weitz, D. A., & Kirschner, M. W. (2015) · Cell · doi:10.1016/j.cell.2015.04.044 · Cited by 3,356
Cellular Heterogeneity: Do Differences Make a Difference?
Altschuler, S. J., & Wu, L. F. (2010) · Cell · doi:10.1016/j.cell.2010.04.033 · Cited by 1,214
Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies
ten Berge, D., Koole, W., Fuerer, C., Fish, M., Eroglu, E., & Nusse, R. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.013 · Cited by 477
Single-cell analysis tools for drug discovery and development
Heath, J. R., Ribas, A., & Mischel, P. S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.16 · Cited by 473
Maisonneuve, E., Castro-Camargo, M., & Gerdes, K. (2013) · Cell · doi:10.1016/j.cell.2013.07.048 · Cited by 438
Retracted
Metadata
- Authors
- Losick, R., & Desplan, C.
- Venue
- Science
- Published
- 2008-04-04
- Volume
- 320
- Issue
- 5872
- Pages
- 65-68
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2132980978
- Cited by
- 635
- References
- 4
- FWCI
- 20.97
- Type
- journal article
- Language
- en
- Open access
- green
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