The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays
Abstract
The DNA origami method, in which long, single-stranded DNA segments are folded into shapes by short staple segments, was used to create nucleic acid probe tiles that are molecular analogs of macroscopic DNA chips. One hundred trillion probe tiles were fabricated in one step and bear pairs of 20-nucleotide-long single-stranded DNA segments that act as probe sequences. These tiles can hybridize to their targets in solution and, after adsorption onto mica surfaces, can be examined by atomic force microscopy in order to quantify binding events, because the probe segments greatly increase in stiffness upon hybridization. The nucleic acid probe tiles have been used to study position-dependent hybridization on the nanoscale and have also been used for label-free detection of RNA.
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Cites
Design and self-assembly of two-dimensional DNA crystals
Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C. (1998) · Nature · doi:10.1038/28998 · Cited by 2,857
Cited by
Fu, J., Liu, M., Liu, Y., Woodbury, N. W., & Yan, H. (2012) · Journal of the American Chemical Society · doi:10.1021/ja300897h · Cited by 699
Self-citationSmart Drug Delivery Nanocarriers with Self‐Assembled DNA Nanostructures
Li, J., Fan, C., Pei, H., Shi, J., & Huang, Q. (2013) · Advanced Materials · doi:10.1002/adma.201300875 · Cited by 441
Folding and cutting DNA into reconfigurable topological nanostructures
Han, D., Pal, S., Liu, Y., & Yan, H. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.193 · Cited by 329
Self-citationBioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons
Stephanopoulos, N., Freeman, R., North, H. A., Sur, S., Jeong, S. J., Tantakitti, F., Kessler, J. A., & Stupp, S. I. (2015) · Nano Letters · doi:10.1021/nl504079q · Cited by 138
A DNA-based system for selecting and displaying the combined result of two input variables
Liu, H., Wang, J., Song, S., Fan, C., & Gothelf, K. V. (2015) · Nature Communications · doi:10.1038/ncomms10089 · Cited by 57
Metadata
- Authors
- Ke, Y., Lindsay, S., Chang, Y., Liu, Y., & Yan, H.
- Venue
- Science
- Published
- 2008-01-11
- Volume
- 319
- Issue
- 5860
- Pages
- 180-183
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046614930
- Cited by
- 460
- References
- 1
- FWCI
- 16.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ke, Y., Lindsay, S., Chang, Y., Liu, Y., & Yan, H. (2008). Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays. Science. https://doi.org/10.1126/science.1150082
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
