A DNA-based system for selecting and displaying the combined result of two input variables
Open accessAbstract
Oligonucleotide-based technologies for biosensing or bio-regulation produce huge amounts of rich high-dimensional information. There is a consequent need for flexible means to combine diverse pieces of such information to form useful derivative outputs, and to display those immediately. Here we demonstrate this capability in a DNA-based system that takes two input numbers, represented in DNA strands, and returns the result of their multiplication, writing this as a number in a display. Unlike a conventional calculator, this system operates by selecting the result from a library of solutions rather than through logic operations. The multiplicative example demonstrated here illustrates a much more general capability—to generate a unique output for any distinct pair of DNA inputs. The system thereby functions as a lookup table and could be a key component in future, more powerful data-processing systems for diagnostics and sensing.
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Recent work on DNA computation has moved away from NP-complete problems toward recreating deterministic logical operations, such as addition and multiplication, with definite outcomes.
“Recent work on DNA computation has moved away from such problems toward recreating deterministic logical operations, for example, addition139 and multiplication,140 with definite outcomes.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [140]
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- Authors
- Liu, H., Wang, J., Song, S., Fan, C., & Gothelf, K. V.
- Affiliations
- Chinese Academy of Sciences (CN)
- Aarhus University (DK)
- Corresponding author
- Fan, Chunhai
- Gothelf, Kurt V.
- Venue
- Nature Communications
- Published
- 2015-12-08
- Volume
- 6
- Issue
- 1
- Pages
- 10089-10089
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4686758
- OpenAlex
- W2261061421
- Cited by
- 57
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 11 · 2017: 9 · 2016: 4
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Aarhus Universitet
- National Research Foundation
- Danmarks Grundforskningsfond (grant number DNRF81, DNRF81)
- Chinese Academy of Sciences
- National Key Research and Development Program of China (2013CB932800, 2012CB932600)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- DNA computing, DNA strand displacement, look-up table, biosensing
- MeSH terms
- DNA, Computers, Molecular
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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