The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Termination Factor Rho and Its Cofactors NusA and NusG Silence Foreign DNA in E. coli
Open accessAbstract
Transcription of the bacterial genome by the RNA polymerase must terminate at specific points. Transcription can be terminated by Rho factor, an essential protein in enterobacteria. We used the antibiotic bicyclomycin, which inhibits Rho, to assess its role on a genome-wide scale. Rho is revealed as a global regulator of gene expression that matches Escherichia coli transcription to translational needs. We also found that genes in E. coli that are most repressed by Rho are prophages and other horizontally acquired portions of the genome. Elimination of these foreign DNA elements increases resistance to bicyclomycin. Although rho remains essential, such reduced-genome bacteria no longer require Rho cofactors NusA and NusG. Deletion of the cryptic rac prophage in wild-type E. coli increases bicyclomycin resistance and permits deletion of nusG . Thus, Rho termination, supported by NusA and NusG, is required to suppress the toxic activity of foreign genes.
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TM4: a free, open-source system for microarray data management and analysis
Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003) · BioTechniques · doi:10.2144/03342mt01 · Cited by 4,837
Sharp, P. M., & Li, W.-H. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.3.1281 · Cited by 3,992
Lateral gene transfer and the nature of bacterial innovation
Ochman, H., Lawrence, J. G., & Groisman, E. A. (2000) · Nature · doi:10.1038/35012500 · Cited by 3,816
Cited by
Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis
Nicolas, P., Mäder, U., Dervyn, E., Rochat, T., Leduc, A., Pigeonneau, N., Bidnenko, E., Marchadier, E., Hoebeke, M., Aymerich, S., et al. (2012) · Science · doi:10.1126/science.1206848 · Cited by 910
A NusE:NusG Complex Links Transcription and Translation
Burmann, B. M., Schweimer, K., Luo, X., Wahl, M. C., Stitt, B. L., Gottesman, M. E., & Rösch, P. (2010) · Science · doi:10.1126/science.1184953 · Cited by 349
Self-citationBacterial Transcription Terminators: The RNA 3′-End Chronicles
Peters, J. M., Vangeloff, A. D., & Landick, R. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.03.036 · Cited by 306
Rho and NusG suppress pervasive antisense transcription in Escherichia coli
Peters, J. M., Mooney, R. A., Grass, J. A., Jessen, E. D., Tran, F., & Landick, R. (2012) · Genes & Development · doi:10.1101/gad.196741.112 · Cited by 264
The complex choreography of transcription-coupled repair
Spivak, G., & Ganesan, A. K. (2014) · DNA Repair · doi:10.1016/j.dnarep.2014.03.025 · Cited by 51
Metadata
- Authors
- Cardinale, C. J., Washburn, R. S., Tadigotla, V. R., Brown, L. M., Gottesman, M. E., & Nudler, E.
- Venue
- Science
- Published
- 2008-05-16
- Volume
- 320
- Issue
- 5878
- Pages
- 935-938
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2121407329
- Cited by
- 311
- References
- 3
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Cardinale, C. J., Washburn, R. S., Tadigotla, V. R., Brown, L. M., Gottesman, M. E., & Nudler, E. (2008). Termination Factor Rho and Its Cofactors NusA and NusG Silence Foreign DNA in E. coli. Science. https://doi.org/10.1126/science.1152763
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