Cited by 51DNA Repair MechanismsNuclear Structure and FunctionGenomics and Chromatin Dynamics

The complex choreography of transcription-coupled repair

Spivak, Graciela, Ganesan, Ann K.·2014·DNA Repair

Abstract

A quarter of a century has elapsed since the discovery of transcription-coupled repair (TCR), and yet our fascination with this process has not diminished. Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA lesions from the genomes of organisms across the evolutionary scale, from bacteria to humans. TCR, defined as a subpathway of NER, is dedicated to the repair of lesions that, by virtue of their location on the transcribed strands of active genes, encumber elongation by RNA polymerases. In this review, we will report on newly identified proteins, protein modifications, and protein complexes that participate in TCR in Escherichia coli and in human cells. We will discuss general models for the biochemical pathways and how and when cells might choose to utilize TCR or other pathways for repair or bypass of transcription-blocking DNA alterations.

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Crossref · 10.1016/j.dnarep.2014.03.025

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  • The temporal hierarchy of NER of UV-induced dipyrimidine photoproducts in mammalian cells is characterized by rapid recognition and excision of 6-4 PPs and preferential repair of CPDs in actively transcribed genes.

    “The temporal hierarchy of NER of UV-induced dipyrimidine photoproducts in mammalian cells is characterized by not only rapid recognition and excision of 6–4 PPs (which are preferentially formed in open chromatin regions), but also preferential repair of CPDs in actively transcribed genes22–24.”

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Authors
Spivak, G., & Ganesan, A. K.
Affiliations
Stanford University (US)
Corresponding author
Spivak, Graciela
Venue
DNA Repair
Publisher
Elsevier BV
Published
2014-07
Volume
19
Pages
64-70
ISSN
  • 1568-7856 (ISSN-L)
  • 1568-7864
OpenAlex
W2068279725
Cited by
51
References
68
Citations by year
2026: 2 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 11 · 2015: 10 · 2014: 7
FWCI
0.91
Type
journal article
Language
en
Open access
closed
Locations
  • DNA repair (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Environmental Health Sciences (ES018834)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
transcription-coupled repair, nucleotide excision repair, DNA damage bypass, RNA polymerase stalling, Escherichia coli, human cells, protein complexes, protein modification, DNA repair pathways
MeSH terms
DNA Damage, DNA Repair, Escherichia coli, Humans, DNA-Directed RNA Polymerases, Transcription, Genetic

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