The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
A NusE:NusG Complex Links Transcription and Translation
Abstract
Transcription and Translation in Train: In bacteria, translation of messenger RNA into proteins by the ribosome usually begins soon after the ribosome binding site emerges from RNA polymerase. Now there is evidence for direct coupling between transcription and translation in bacteria. Proshkin et al. (p. 504 ; see the Perspective by Roberts ) show that the trailing ribosome controls the rate of transcription by preventing RNA polymerase from spontaneous backtracking, which allows precise adjustment of transcriptional yield to translational needs under various growth conditions. Burmann et al. (p. 501 ; see the Perspective by Roberts ) provide a potential mechanism for coupling by showing that the transcription factor NusG, which binds RNA polymerase through its amino-terminal domain, competitively binds either a ribosomal protein or the Rho transcription termination factor through its carboxy-terminal domain. Rho binding might occur after release of the ribosome from messenger RNA, thus linking termination of transcription and translation.
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Cites
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Termination Factor Rho and Its Cofactors NusA and NusG Silence Foreign DNA in E. coli
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Self-citationRegulator Trafficking on Bacterial Transcription Units In Vivo
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Self-citation
Cited by
Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis
Nicolas, P., Mäder, U., Dervyn, E., Rochat, T., Leduc, A., Pigeonneau, N., Bidnenko, E., Marchadier, E., Hoebeke, M., Aymerich, S., et al. (2012) · Science · doi:10.1126/science.1206848 · Cited by 910
Evolution of multisubunit RNA polymerases in the three domains of life
Werner, F., & Grohmann, D. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2507 · Cited by 431
Mechanisms of Bacterial Transcription Termination: All Good Things Must End
Ray-Soni, A., Bellecourt, M. J., & Landick, R. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014844 · Cited by 351
Bacterial Transcription Terminators: The RNA 3′-End Chronicles
Peters, J. M., Vangeloff, A. D., & Landick, R. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.03.036 · Cited by 306
In-cell architecture of an actively transcribing-translating expressome
O’Reilly, F. J., Xue, L., Graziadei, A., Sinn, L., Lenz, S., Tegunov, D., Blötz, C., Singh, N., Hagen, W. J. H., Cramer, P., et al. (2020) · Science · doi:10.1126/science.abb3758 · Cited by 284
Metadata
- Authors
- Burmann, B. M., Schweimer, K., Luo, X., Wahl, M. C., Stitt, B. L., Gottesman, M. E., & Rösch, P.
- Venue
- Science
- Published
- 2010-04-23
- Volume
- 328
- Issue
- 5977
- Pages
- 501-504
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023476648
- Cited by
- 349
- References
- 24
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- closed
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