The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The Flavivirus Precursor Membrane-Envelope Protein Complex: Structure and Maturation
Abstract
Many viruses go through a maturation step in the final stages of assembly before being transmitted to another host. The maturation process of flaviviruses is directed by the proteolytic cleavage of the precursor membrane protein (prM), turning inert virus into infectious particles. We have determined the 2.2 angstrom resolution crystal structure of a recombinant protein in which the dengue virus prM is linked to the envelope glycoprotein E. The structure represents the prM-E heterodimer and fits well into the cryo–electron microscopy density of immature virus at neutral pH. The pr peptide β-barrel structure covers the fusion loop in E, preventing fusion with host cell membranes. The structure provides a basis for identifying the stages of its pH-directed conformational metamorphosis during maturation, ending with release of pr when budding from the host.
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Cites
Kuhn, R. J., Zhang, W., Rossmann, M. G., Pletnev, S. V., Corver, J., Lenches, E., Jones, C. T., Mukhopadhyay, S., Chipman, P. R., Strauss, E. G., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00660-8 · Cited by 1,563
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Chemical and biological evolution of a nucleotide-binding protein
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Self-citationThe envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution
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A structural perspective of the flavivirus life cycle
Mukhopadhyay, S., Kuhn, R. J., & Rossmann, M. G. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1067 · Cited by 1,292
Self-citationStructure of the dengue virus envelope protein after membrane fusion
Modis, Y., Ogata, S., Clements, D., & Harrison, S. C. (2004) · Nature · doi:10.1038/nature02165 · Cited by 1,203
A ligand-binding pocket in the dengue virus envelope glycoprotein
Modis, Y., Ogata, S., Clements, D., & Harrison, S. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0832193100 · Cited by 1,061
Structure of the Immature Dengue Virus at Low pH Primes Proteolytic Maturation
Yu, I.-M., Zhang, W., Holdaway, H. A., Li, L., Kostyuchenko, V. A., Chipman, P. R., Kuhn, R. J., Rossmann, M. G., & Chen, J. (2008) · Science · doi:10.1126/science.1153264 · Cited by 623
Self-citationStructure of a flavivirus envelope glycoprotein in its low‐pH‐induced membrane fusion conformation
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Proteolytic activation of tick-borne encephalitis virus by furin
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Cited by
Wilm, A., Aw, P. P. K., Bertrand, D., Yeo, G. H. T., Ong, S. H., Wong, C. H., Khor, C. C., Petric, R., Hibberd, M. L., & Nagarajan, N. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks918 · Cited by 1,372
Harrison, S. C. (2015) · Virology · doi:10.1016/j.virol.2015.03.043 · Cited by 697
Structure of the Immature Dengue Virus at Low pH Primes Proteolytic Maturation
Yu, I.-M., Zhang, W., Holdaway, H. A., Li, L., Kostyuchenko, V. A., Chipman, P. R., Kuhn, R. J., Rossmann, M. G., & Chen, J. (2008) · Science · doi:10.1126/science.1153264 · Cited by 623
Self-citationWeaver, S. C., & Vasilakis, N. (2009) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2009.02.003 · Cited by 531
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
Yuan, L., Huang, X.-Y., Liu, Z.-Y., Zhang, F., Zhu, X.-L., Yu, J.-Y., Ji, X., Xu, Y.-P., Li, G., Li, C., et al. (2017) · Science · doi:10.1126/science.aam7120 · Cited by 473
Metadata
- Authors
- Li, L., Lok, S.-M., Yu, I.-M., Zhang, Y., Kuhn, R. J., Chen, J., & Rossmann, M. G.
- Venue
- Science
- Published
- 2008-03-28
- Volume
- 319
- Issue
- 5871
- Pages
- 1830-1834
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2166561873
- Cited by
- 554
- References
- 17
- FWCI
- 27.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, L., Lok, S.-M., Yu, I.-M., Zhang, Y., Kuhn, R. J., Chen, J., & Rossmann, M. G. (2008). The Flavivirus Precursor Membrane-Envelope Protein Complex: Structure and Maturation. Science. https://doi.org/10.1126/science.1153263
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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