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From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins

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High-Dose Intravenous Immunoglobulin in Skin Autoimmune Disease

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Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development

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Antibody-mediated kidney allograft rejection: therapeutic options and their experimental rationale

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Chinese hamster ovary (CHO) host cell engineering to increase sialylation of recombinant therapeutic proteins by modulating sialyltransferase expression

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With or Without Sugar? (A)glycosylation of Therapeutic Antibodies

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Glycosylation as a marker for inflammatory arthritis

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Engineering host cell lines to reduce terminal sialylation of secreted antibodies

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Electrochemical lectin based biosensors as a label-free tool in glycomics

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The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals

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Site specific N- and O-glycosylation mapping of the spike proteins of SARS-CoV-2 variants of concern

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Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis

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Analytical and Functional Aspects of Antibody Sialylation

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Intravenous Immunoglobulin: Mechanism of Action in Autoimmune and Inflammatory Conditions

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In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

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Arthrobacter Endo‐β‐N‐Acetylglucosaminidase Shows Transglycosylation Activity on Complex‐Type N‐Glycan Oxazolines: One‐Pot Conversion of Ribonuclease B to Sialylated Ribonuclease C

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Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors

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New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura

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Glycoengineering in CHO cells: advances in systems biology

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Passively Administered Pooled Human Immunoglobulins Exert IL-10 Dependent Anti-Inflammatory Effects that Protect against Fatal HSV Encephalitis

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Preparations of intravenous immunoglobulins diminish the number and proinflammatory response of CD14+CD16++ monocytes in common variable immunodeficiency (CVID) patients

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Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

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Effective Assignment of α2,3/α2,6‐Sialic Acid Isomers by LC‐MS/MS‐Based Glycoproteomics

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High-Dose Intravenous Immunoglobulins in the Treatment of Severe Acute Viral Pneumonia: The Known Mechanisms and Clinical Effects

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Strategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation

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Aglycosylated full-length IgG antibodies: steps toward next-generation immunotherapeutics.

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Treatment Response in Kawasaki Disease Is Associated with Sialylation Levels of Endogenous but Not Therapeutic Intravenous Immunoglobulin G

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Improving Immunotherapy Through Glycodesign

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Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa

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The sweet spot for biologics: recent advances in characterization of biotherapeutic glycoproteins

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Glycosylation Profile of IgG in Moderate Kidney Dysfunction

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Inflammation and Healing

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New paradigms for functional HIV-specific nonneutralizing antibodies

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Strategies for Glycoengineering Therapeutic Proteins

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Glycosylation Shapes the Efficacy and Safety of Diverse Protein, Gene and Cell Therapies

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Intravenous immunoglobulins induce potentially synergistic immunomodulations in autoimmune disorders

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Advances in Immunotherapy for Tuberculosis Treatment

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Mechanisms of action of intravenous immunoglobulins

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Glycosylation of monoclonal antibody products: Current status and future prospects

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Modulation of antibody effector function

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Fc receptors: Cell activators of antibody functions

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Enhancing glycoprotein sialylation by targeted gene silencing in mammalian cells

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COVID-19 and myocarditis: a review of literature

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IgG Fc N-Glycosylation in Guillain–Barré Syndrome Treated with Immunoglobulins

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Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice

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Regulation of immunity and inflammation by intravenous immunoglobulin: relevance to solid organ transplantation

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Recent Advances in Clinical Glycoproteomics of Immunoglobulins (Igs)

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Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model

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Mechanisms of immune regulation by IVIG

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A Prospective, Randomized, Double-Blinded, Placebo-Controlled Study of Human Intravenous Immunoglobulin for the Acute Management of Presumptive Primary Immune-Mediated Thrombocytopenia in Dogs

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Fc Glycan-Modulated Immunoglobulin G Effector Functions

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Treatment options in myocarditis and inflammatory cardiomyopathy

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Anti-inflammatory IgG Production Requires Functional P1 Promoter in β-Galactoside α2,6-Sialyltransferase 1 (ST6Gal-1) Gene

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High-Dose Intravenous Immunoglobulin (IVIG) Therapy in Autoimmune Skin Blistering Diseases

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Type 2 Diabetes Mellitus: Integrative Analysis of Multiomics Data for Biomarker Discovery

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New strategies for profiling and characterization of human milk oligosaccharides

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The glyco-redox interplay: Principles and consequences on the role of reactive oxygen species during protein glycosylation

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Cardiomyopathies: Classification, Diagnosis, and Treatment

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Trichinella spiralisimmunomodulation: an interactive multifactorial process

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Human DC-SIGN and CD23 do not interact with human IgG

Temming, A. R., Dekkers, G., van de Bovenkamp, F. S., Plomp, H. R., Bentlage, A. E. H., Szittner, Z., Derksen, N. I. L., Wuhrer, M., Rispens, T., & Vidarsson, G. (2019) · Scientific Reports · doi:10.1038/s41598-019-46484-2 · Cited by 56

A synopsis of recent developments defining how N-glycosylation impacts immunoglobulin G structure and function

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Standard and etiology-directed evidence-based therapies in myocarditis: state of the art and future perspectives

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A Perspective on the Structure and Receptor Binding Properties of Immunoglobulin G Fc

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Autoimmune Neurological Disorders with IgG4 Antibodies: a Distinct Disease Spectrum with Unique IgG4 Functions Responding to Anti-B Cell Therapies

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Multifocal Motor Neuropathy, Multifocal Acquired Demyelinating Sensory and Motor Neuropathy, and Other Chronic Acquired Demyelinating Polyneuropathy Variants

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Remodeling of Marrow Hematopoietic Stem and Progenitor Cells by Non-self ST6Gal-1 Sialyltransferase

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Identification of functional elements of the GDP-fucose transporter SLC35C1 using a novel Chinese hamster ovary mutant

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Pharmacokinetic and Pharmacodynamic Considerations in the Design of Therapeutic Antibodies

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Monocyte Recruitment by HLA IgG-Activated Endothelium: The Relationship Between IgG Subclass and FcγRIIa Polymorphisms

Valenzuela, N. M., Trinh, K. R., Mulder, A., Morrison, S. L., & Reed, E. F. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13174 · Cited by 52

Toward a Platform for Comprehensive Glycan Sequencing

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Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment

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CDG and immune response: From bedside to bench and back

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IgG4-Mediated Neurologic Autoimmunities: Understanding the Pathogenicity of IgG4, Ineffectiveness of IVIg, and Long-Lasting Benefits of Anti-B Cell Therapies.

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Effect of Fc-Glycan Structure on the Conformational Stability of IgG Revealed by Hydrogen/Deuterium Exchange and Limited Proteolysis

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Induction of Regulatory T Cells by Intravenous Immunoglobulin: A Bridge between Adaptive and Innate Immunity

Kaufman, G., Massoud, A. H., Dembele, M., Yona, M., Piccirillo, C. A., & Mazer, B. D. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00469 · Cited by 50

Unusual Transglycosylation Activity of Flavobacterium meningosepticum Endoglycosidases Enables Convergent Chemoenzymatic Synthesis of Core Fucosylated Complex N‐Glycopeptides

Huang, W., Li, J., & Wang, L. (2011) · ChemBioChem · doi:10.1002/cbic.201000763 · Cited by 50

Use of immunoglobulins in the prevention of GvHD in a xenogeneic NOD/SCID/γc− mouse model

Gregoire-Gauthier, J., Durrieu, L., Duval, A., Fontaine, F., Dieng, M. M., Bourgey, M., Patey, N., Louis, I., & Haddad, É. (2011) · Bone Marrow Transplantation · doi:10.1038/bmt.2011.93 · Cited by 49

From Whole Monoclonal Antibodies to Single Domain Antibodies: Think Small

Teillaud, J. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-968-6_1 · Cited by 49

Myasthenia gravis in dogs with an emphasis on treatment and critical care management

Khorzad, R., Whelan, M. F., Sisson, A., & Shelton, G. D. (2011) · Journal of Veterinary Emergency and Critical Care · doi:10.1111/j.1476-4431.2011.00636.x · Cited by 49

Immune recruitment or suppression by glycan engineering of endogenous and therapeutic antibodies

Le, N. P. L., Bowden, T. A., Struwe, W. B., & Crispin, M. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.04.016 · Cited by 48

Frontline Science: Plasma and immunoglobulin G galactosylation associate with HIV persistence during antiretroviral therapy

Vadrevu, S. K., Trbojević‐Akmačić, I., Kossenkov, A. V., Colomb, F., Giron, L. B., Anzurez, A., Lynn, K., Mounzer, K., LANDAY, A. L., Kaplan, R. C., et al. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3hi1217-500r · Cited by 49

Tregitope: Immunomodulation Powerhouse

Cousens, L. P., Najafian, N., Martin, W. D., & Groot, A. S. D. (2014) · Human Immunology · doi:10.1016/j.humimm.2014.10.012 · Cited by 49

Intravenous immunoglobulin and Alzheimer’s disease: what now?

Loeffler, D. A. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-70 · Cited by 52

Role of N-Glycosylation in FcγRIIIa interaction with IgG

Coillie, J. V., Schulz, M. A., Bentlage, A. E. H., de Haan, N., Ye, Z., Geerdes, D. M., van Esch, W. J. E., Hafkenscheid, L., Miller, R. L., Narimatsu, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.987151 · Cited by 53

Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis

Thiruppathi, M., Sheng, J. R., Li, L., Prabhakar, B. S., & Meriggioli, M. N. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.12.014 · Cited by 48

Microbiomic and Posttranslational Modifications as Preludes to Autoimmune Diseases

Opdenakker, G., Proost, P., & Damme, J. V. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.07.002 · Cited by 48

Integrated Genome and Protein Editing Swaps α‐2,6 Sialylation for α‐2,3 Sialic Acid on Recombinant Antibodies from CHO

Chung, C., Wang, Q., Yang, S., Yin, B., Zhang, H., & Betenbaugh, M. J. (2016) · Biotechnology Journal · doi:10.1002/biot.201600502 · Cited by 50

Autoimmunity as a trigger for structural bone damage in rheumatoid arthritis

Schett, G. A. (2017) · Modern Rheumatology · doi:10.1080/14397595.2016.1265907 · Cited by 45

Sequence-to-structure dependence of isolated IgG Fc complex biantennary N -glycans: a molecular dynamics study

Harbison, A. M., Brosnan, L. P., Fenlon, K., & Fadda, E. (2018) · Glycobiology · doi:10.1093/glycob/cwy097 · Cited by 48

with a Recombinant IgG Fc Recapitulation of IVIG Anti-Inflammatory Activity

Anthony, R. M. (2008)

Research Highlights

Okoreeh, M. K., & Luo, X. (2026) · Transplantation · doi:10.1097/tp.0000000000005610

The anti-inflammatory activity of IgG is enhanced by co-engagement of type I and II Fc receptors

Jones, A., Marino, A. E., Martynyuk, T., Bournazos, S., & Ravetch, J. V. (2025) · Science · doi:10.1126/science.adv2927 · Cited by 11

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

Washburn, N., Schwab, I., Ortiz, D., Bhatnagar, N., Lansing, J. C., Medeiros, A., Tyler, S., Mekala, D., Cochran, E., Sarvaiya, H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422481112 · Cited by 225

Novel Fc receptors mediating the anti-inflammatory properties of IgG

Ravetch, J. V. (2010)