Cited by 849Monoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins ResearchT-cell and B-cell Immunology

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

Open access

Abstract

It is well established that high doses of monomeric immunoglobulin G (IgG) purified from pooled human plasma [intravenous immunoglobulin (IVIG)] confer anti-inflammatory activity in a variety of autoimmune settings. However, exactly how those effects are mediated is not clear because of the heterogeneity of IVIG. Recent studies have demonstrated that the anti-inflammatory activity of IgG is completely dependent on sialylation of the N-linked glycan of the IgG Fc fragment. Here we determine the precise glycan requirements for this anti-inflammatory activity, allowing us to engineer an appropriate IgG1 Fc fragment, and thus generate a fully recombinant, sialylated IgG1 Fc with greatly enhanced potency. This therapeutic molecule precisely defines the biologically active component of IVIG and helps guide development of an IVIG replacement with improved activity and availability.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.1154315

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 34 references

Cited by

Sorted by citations

Items 701–800 of 847

Metadata

Authors
Anthony, R. M., Nimmerjahn, F., Ashline, D. J., Reinhold, V. N., Paulson, J. C., & Ravetch, J. V.
Affiliations
Scripps Research Institute (US)
Corresponding author
Ravetch, Jeffrey V.
Venue
Science
Published
2008-04-18
Volume
320
Issue
5874
Pages
373-376
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2051666192
Cited by
849
References
34
Citations by year
2026: 19 · 2025: 32 · 2024: 29 · 2023: 37 · 2022: 39 · 2021: 39 · 2020: 50 · 2019: 39 · 2018: 45 · 2017: 46 · 2016: 66 · 2015: 58 · 2014: 58 · 2013: 58 · 2012: 68
FWCI
42.36
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01gm060938-10)
  • National Institute of General Medical Sciences (R01GM054045, R01-GM060938, GM60938)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
intravenous immunoglobulin, anti-inflammatory activity, IgG Fc fragment, sialylation, N-glycans, glycan engineering, autoimmune disease
MeSH terms
Animals, Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Experimental, Autoimmune Diseases, Carbohydrate Conformation, Galactose, Glycosylation, Humans, Immunoglobulin G, Immunoglobulin Fc Fragments, Mice, Inbred C57BL, Polysaccharides, Receptors, Fc, Recombinant Proteins, Purpura, Thrombocytopenic, Idiopathic, Mice, Inbred NOD, Immunoglobulins, Intravenous, N-Acetylneuraminic Acid, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review